Liver-interfering medication drugs causes deficiency of neurotransmitters and hormones for no sexual orgasm.

Reader: 5/19/2003>
Dear Dr.Lin:
I have always had a very high sex drive with no problem having a orgasm.
However, recently I have had problems with orgasm, since I have been
taking comadin, for a blood clot. I still have menstral periods although
having missed two months in 2002. For 2003 so far I have missed Jan and
recently April 2003. By the way, my best climax is from oral sex,although
I do enjoy penetration. I also have a very retroverted uterous so a large
penis is very painful for me. I did have myomectomy in 1999 still a few
small fibrod n the wall of my uterous, but it helped some. In summary
my major concern is having that huge climax I miss from oral sex. I can
reach it sometime but now I must wait a couple of weeks to achieve it again
or longer.
Thank you very, very for your advice. ( taking comadin for 5months)

Dr. Lin: 5/20/2003> Drugs usually interfere with the liver function that supports the synthesis of nervous transmitters from proteins (amino acids), cholesterol and its hormone conversion, blood sugar and its metabolism in cells. Some drugs cut down the nervous transmission; others block the cholesterol/hormone synthesis. Your blood clot drugs generally interfere with metabolism of proteins (amino acids) to neurotransmitters and the cholesterol-hormone conversions. Reducing the synthesis of cholesterol and amino acids can thin the blood and help erode the clot away.
Unfortunately, at a high dose (the standard dose), it interferes the liver function, resulting in deficiency of the neurotransmitters acetylcholine/dopamine and androstenedione/testosterone that support the sexual and orgasmic responses. You also start your menopause. this is another factor associated with a drop of the ovarian hormone androstenedione.
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