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Welcome to Orgasm Research Center 
In GOD we trust; all others provide evidences - data and cases! Yes, we got them all!  Since 1997,  we have collected human and animal sexual and drug experiences and experiments, classical, empirical and academic,  from 5000 years ago to today,  to share with you! Here, we deal with Sexual Exhaustion Symptoms, resulting from the evolution (or neuroplasticity)  of both the hypothalamus-pituitary-adrenal axis and the neuro-immune system induced by excessive sex, drug abuse, and traumatic stress.
Therefore, we have collected historical lessons and cases to support our claims as :
Suffering is Believing, Seeing is Believing, Hearing is Believing, Forgetting is Believing, Shaking is Believing; Dizzying is Believing; Head-aching is Believing; Peeing is Believing; Vibrating is Believing; Tiring is Believing; Depressing is Believing; Feeling is Believing; Stressing is Believing; ReTooling is Believeing; Pleasing is Believing;
or get Benefits from Optimal Orgasms (This is what you love to hear about. Yes, orgasm and sex can help improve your health!)

Dr. Lin uncovered the mystery of sexual orgasm!

Warning, Warning: Finally,   some conscious researchers want to tell you that high-frequency sexual activity (intercourse, masturbation, overall) may increase risk of prostate cancer as given in https://www3.interscience.wiley.com/journal/121510647/abstract.  It is not a joke! But, do you believe in them this time since the last time you were told that masturbation can reduce prostate cancer risk (yes, and you got excited by the "good" news which becomes your nightmare now!)?  Dr Lin has collected the ill effects (sexual exhaustion symptoms) from Over-masturbation/Over-ejaculation/Excessive Orgasm since 1997 to prove what the 5000-year old Chinese medical text said.  Dr. Lin has concluded sex/psychological- induced  excessive prolactin, norepinephrine, epinephrine and prostaglandin E2 can cause autoimmune disorders (more reference?), brain overheating with fever/flu-like symptoms ( https://ajpregu.physiology.org/cgi/content/full/294/4/R1294 ) vasoconstriction ( although prostaglandin E2 is an inflammator as well as a dilator),  fear, anxiety, restlessness, pounding headaches, dizziness, tremors, weakness, respiratory difficulty, palpitations, cardiac arrhythmias, skin cancers, skin disorders (including acne ), allergy, asthma, hair loss( more reference, and more; on hair cycling), neuroplasticity ( https://www.la-press.com/redirect_file.php?fileId=829&filename=GRSB-1-Akenaya&fileType=pdf  )and cancerous/tumorous cellular development and locomotion,  and ignite negative neuro-immuro-reaction, arterial constriction (via the alpha-adrenergic receptors) / inflammatory narrowness and venous constriction for blood-cutoff castration of the hypothalamus-pituitary-testicular axis and heart diseases, and inflammatory responses. Interrupting the stimulation of nuerohormones norepinephrine and epinephrine on the beta-adrenergic receptors via the sympathetic nerves (T10-L2) results in the prostate atrophy for spinal-injured men- https://www.nature.com/sc/journal/v44/n1/abs/3101804a.html while sympathetic nervous over-excitation of the neurohormones on the prostate causes prostate enlargement and pains.  For more information on Cancer, Sex and Stress, please click here - Stress Increases Prostate (and Ovarian) Cancer Risk. Yes, ovarian cancer too (yes, more reference); actually, any types of cancers or tumors, (for examples: skin cancers, colon cancer, liver cancer, et. al.) as well; and neuroplastic Post-Stress-Trauma brain/nervous damage. No doubt, current researches have tied breast and prostate cancers to excessive prolactin release and stress hormones norepinephrine (more?)and epinephrine  By the way, if you have been misled to over-masturbation, over-ejaculation (high-frequency ejaculation),  or excessive sex, our products can help you get recovery from Sexual Exhaustion Symptoms unless your testicular function was fully castrated by excessive sex. When sex stresses your Hypothalamus-Pituitary-Adrenal  (HPA) axis out, you get neuroplastic Post-Sex Stress Trauma Disorders (PSSTD), that is Dr. Lin's Sexual Exhaustion Symptoms, but no health benefit at all: you die for sex like insects! Are you on the way to selfdestruction?  By the way, you may would like to know what are effects of  semen and sperms on you can your partner (please click here)!  Maybe, you should learn about "The effects of stress hormones norepinephrine and epinephrine on cancers , the
sympathetically-driven cancers."

Why?  Consider the Sexual Arousal Neuroimmune Pathway: The dopamine nervous system stimulates the hypothalamus-pituitary axis, with orchestral effects of androgen hormones DHEA/testosterone/DHT  ( https://csbn.concordia.ca/Faculty/Pfaus/docs/Damsma,Pfaus,Wenkstern,Phillips,Fibiger%20(1992)%20Behav%20Neurosci.pdf, https://www.jneurosci.org/cgi/reprint/17/12/4849 ,  https://synapse.koreamed.org/Synapse/Data/PDFData/0162PI/pi-6-194.pdf
https://pdf.medrang.co.kr/paper/pdf/Androl/Kjan018-02-09.pdf ,
https://pdf.medrang.co.kr/Kju/035/Kju035-05-02.pdf 
https://pdf.medrang.co.kr/Kju/039/Kju039-05-05.pdf 
https://www.nature.com/ijir/journal/v13/n3s/pdf/3900719a.pdf ),  to activate the norepinephrine/sympathetic nervous action and the oxytocin, NOergic (NO = Nitric Oxide - released from the parasympathetic nervous endings)  and prostaglandin E2 stimulation on sex organs (prostate, seminal vesicles, penis and testicles, clitoris, uterus, vagina and ovaries), leading to the induction of swelling/congestive/inflammatory  pressure, arterial dilation and nervous sensitivity.  The swelling/congestive/inflammatory pressure won't give you pain, but nervous sensitivity if the tissues release sufficient prostaglandins E1 and E3 to relax the nerves and blood vessels and to enhance their elasticity and flexibility.  This is how sexual desire initiates and how people experience the persistent sexual arousal symptom. Noticeably, the highly stretched penile nerves may be desensitized when a penis is ballooned into the 2nd stage erection where the erecting penis becomes about 120% bigger than the initial erection. This exception can be achieved by the penile ballooning enlargement where prostaglandins E1/E2/E3,  androgen hormones, oxytocin, histamine, sympathetic and parasympathetic nervous erectile mechanism are synchronically working together.   Before sexual exhaustion, prostaglandin E2, with oxytocin and histamine,  acts as a vasodepressor/vasodilator; after sexual exhaustion, it, with a high level of prolactin and a lack of oxytocin and NO release,  becomes vasopressor/vasoconstrictor and arterial/venous narrowing  imflammator,  even with a high level of histamine. The tricky roles of prostaglandin E2 are also described in https://hyper.ahajournals.org/cgi/reprint/35/5/1129 .  Men or women can get a lot of erection, sex-organ swelling, and sexual desire from the stimulation of prostaglandin E2 (in conjunction with a high level of histamine release) with a high price - inflammatory body pains, congestive headaches, dizziness, or/and excessive, unwanted leakage/discharge out of the penis/vagina, if the cholinergic/vagal/serotonin/GABA nervous function, in conjunction with action of androgen hormones and prostaglandins E1 and E3,  are too weak to modulate the local inflammatory response induced by noradrenergic (norepinephrine)/sympathetic nervous fires (pyrogens) and prostaglandin E2 in the sympathetic adrenergic receptors.  In the brain, the hypothalamic dopamine-norepinephrine conversion during sexual arousal triggers endogenous pyrogens to act on the Organum Vasculation of the Lamina Terminalis of the third ventricle to promote prostaglandin E2 release to open the blood-brain barriers for more androgen hormones (stress hormones and toxins too!) to enter the brain and central nervous system, and to elevate the core temperature for sex heat. That is why you feel heat and warm when you become sexual arousal.  You may feel dizziness in your first encounter with a new partner. In the body, prostaglandin E2 promotes bradykinin-induced pains, spinal/back pains, the coagulation of platelets, bone resorption and formation (good!), immune disabling (for infection, but good for making babies: 1. de-activating the urethral, vaginal and uterine immune to help sperms survive through male ejaculation duct, female vagina, cervix, and uterus; 2. disabling the egg immune to help a sperm fertilize the egg; 3. disabling the uterine immune to allow the fertilized egg to be implanted or transplanted; 4. inducing labor (orgasms too)),  cancer and carcinogenesis, hypertension,  muscle protein degradation (muscular weakness and shrinkage), cardiovascular disorders, and synaptic neuroplasticity for alternation and reprogramming of brain/nervous functions (for better or worse), short-and long-term memory (including sexual pleasures!), addiction (of drug and sex!), alzheimer's disease, psychological disorders, and promotion of chronic noradrenergic/sympathetic fight or flight responses. You see, prostaglandin E2 plays the role of the good, the bad and the ugly in your life from the beginning to the end (death.)
Thus,  sex is a neuro-immune and hypothalamus-pituitary-adrenal and -testicular (-ovarian) challenge, good (constructive) or bad (destructive) depending on how you manipulate and perform it.  Sexual arousal or orgasm triggers the neuro-immuno-endocrine function for better or worse, depending on the immunoreaction of the noradrenergic (norepinephrine)/sympathetic nervous system to its resulted stress  and on the balance of its induced pro-inflammatory and anti-inflammatory responses. If you ignore the neuro-immune responses to sex-induced stressors norepinephrine and epinephrine, sex will destroy your health for no more orgasm, but pains and psychological disorders like drug abuse.  The neuro-immune-endocrine responses to sex-induced stress are driven by the sympathetic nervous alpha- and beta-adrenergic receptors of the immune cells which release immunotransitters cytockines and protein kinases for pro-inflammation or/and anti-inflammation.  The classic Taoism teaching considers sex as a powerful drug for better or worse, up to individual practices.   Don't become a LOOSER!
Over-masturbation/over-ejaculation/excessive-orgasm can castrate the hypothalamus-pituitary-testicular(ovarian) axis by arterial constriction and inflammatory narrowness in your brain and pelvic organs (testicles, prostate, seminal vesicles, penis, ovaries, uterus, vagina and clitoris) due to excessive release of prolactin, norepinephrine, and epinephrine, excessive binding of norepinephrine/epinephrine on the alpha-adrenergic receptors, the norepinephrine/epinephrine induced excessive prostaglandin E2, and the post-sex deficiency of nitric oxide and prostaglandins E1/E3 production. As a result of arterial constriction and inflammatory narrowness (leading to  arterial thrombosis and atherothrombosis! https://jem.rupress.org/cgi/content/full/204/2/311;  https://jpet.aspetjournals.org/cgi/content/full/300/2/393; https://jem.rupress.org/cgi/content/full/204/2/311  ),  your brain, testicles, penis, (clitoris, vulva, G-spot, vagina, uterus and ovaries for women)  feet and hands get low blood supplies and less androgen hormones and nuerochemicals, but more inflammatory hormone production and stress hormones.  And, it will take a long time for you to get recovery from sexual exhaustion and post-sex inflammation. You may also wonder why your  penis or clitoris go limps and your vagina become dry in the middle of sex.  When your adrenal and testicular (or ovarian) function are disabled, you will have to rely on the skin neruoendocrine function to elevate your androgen hormones.  Please also note that prostaglandin E2 also inflame veins too - https://atvb.ahajournals.org/cgi/content/full/18/10/1655,  https://ajpcell.physiology.org/cgi/content/full/281/3/C1038, https://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=199422, and  https://atvb.ahajournals.org/cgi/content/full/17/9/1644 .  When you get inflamed arteries and veins, your blood circulation won't reach the inflamed areas and you will experience pain, numbness or cramp .  As for sex, you don't want inflamed arteries and veins in your penis and testicles (clitoris, labia, G-spot,  vagina. uterus (and its support ligaments and tissues) and ovaries for women), do you?

In addition, excessively accumulation of prolactin as a result of  high-frequency ejaculation or orgasm disables the activin release from the testicles, epididymis, prostate,and seminal vesicles (or ovaries for women),  leading to a low pituitary FSH release, followed by a low pituitary LH release, resulting in deficiency of androgen hormonal production from the testicles and ovaries. On the other hand, activin is a negative regulator of prolactin and cell growth ( https://mend.endojournals.org/cgi/content/full/18/6/1558 ). Without sufficient activin, the excessive release prolactin becomes persistent,  and thus the androgen hormones (testosterone and DHT) level remains too low to help the exhausted hypothalamus-pituitary-adrenal and testicular (ovarian) axis to recover from sexual exhaustion or post-sex illness or to suppress the inflammatory pains. No wonder, you will experience persistent  sexual exhaustion, fatigue, tiredness and inflammatory pains. 

Recent studies show that sexual exhaustion also reduces the androgen receptor density and expression, but upregulates estrogen receptor alpha expression,  particularly in  in the medial preoptic area (MPOA),  ventromedial hypothalamic nucleus (VMH), medial amygdala (MeA),  and lateral septum, ventral part (LSV) -  https://www.ncbi.nlm.nih.gov/pubmed/12914589 , https://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=000099250, https://www.ncbi.nlm.nih.gov/pubmed/17239879?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=3&log$=relatedarticles&logdbfrom=pubmed  https://www.ncbi.nlm.nih.gov/pubmed/19073212?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=5&log$=relatedreviews&logdbfrom=pubmed 
These researches basically re-verify the effectiveness of our products which were in the markets for solve sexual exhaustion symptoms long before these studies were done. However, the studies doesn't address catastrophic (permanent) castration of the pituitary-testicular and ovarian axis due to excessive prolactin and norepinephrine induced arterial and venous constriction and inflammatory narrowness in the brain, testicles, penis, ovaries, clitoris and other pelvic organs. We have found there are about 5-10% of sexual exhausted patients unable to get recovery.

Why are sexual exhaustion symptoms complicated by the exhaustion of the hypothalamus-pituitary-adrenal and -testicular (-ovarian) axis and the destruction of the dopamine, cholinergic/vegal/parasympathetic, serotonin and GABA nervous function with inflammatory responses?
Orgasm-stress induced inflammatory hormone prostaglandin E2  can over-excite mast cells to release histamine to activates the central histaminergic nerves and other numerous vasoactive, neurosensitizing and inflammatory molecules.  Histamine and its receptors are very dense in the hypothalamus, heart, lungs and arteries; Psychological or physiological stress, including sex-induced stress,  can induce significant alterations in both histamine synthesis and its concentration in several brain regions. During stress reactions, histamine may act as a neurotransmitter within the hypothalamus. A high density of brain mast cells in regions situated at the boundary between the central nervous system (CNS) and its surroundings such as in the circumventricular organs and median eminence can induce immediate hypersensitivity either in the CNS or in the periphery.  This gives you orgasmic headaches, allergic responses,  asthma, sneezing,  sinus,  itchiness, scalping burning sensation, hair loss and premature ejaculation.  Histamine, in turn, may also trigger the release of various stress hormones to prolong your sex-induced stress for several days.  Psychological or physiological stress, including orgasm/sex-induced stress also induces cardiac mast cell activation and histamine release into the bloodstream. Chronic excessive norepinephrine and its induced excessive histamine and prostaglandin E2 promote the development of atherosclerosis, coronary inflammation and cardiac ischemia, besides environmental toxins such as smoking (nicotine, pot, etc.).  In myocardial ischemia, excessive norepinephrine release causes severe arrhythmias and sudden cardiac death. Recent studies shows histamine H3-receptors can provide a negative feedback control for the release of norepinephrine from the sympathetic nervous endings, and for a number of other neurotransmitters such as histamine itself, dopamine, GABA, acetylcholine, and serotonin. But, this negative feed control can be easily breakdown by excessive stress. On the other hands, histamine H1 and H2 receptors promote cardiac disorders.  Reduction of endogenous histamine release or/and blockade of histamine H1 and H2 receptors can protects against ischemia. This is why there are  a lot of reports about  sudden death or cardiac arrest during intercourse or masturbation when histamine stimulates H1 and H2 receptors more than H3.  And, severe allergy can cause cardiac arrest.  However, what happens when histamine over-stimulates H3 but understimulate H1 and H2?  In this regard, you will likely experience the sexual exhaustion symptoms resulted from post-sex deficiency of dopamine, acetylcholine, norepinephrine, serotonin and GABA.  Unfortunately, in the most of sexual exhaustion symptoms we have collected, it seems H3 fails to negatively feedback control the norepinephrine and histamine release since sexual arousal, orgasm or ejaculation always triggers the hypothalamic and adrenal dopamine-norepinephrine conversion and histamine release when you are in the exhaustion state of the hypothalamus-pituitary-adrenal axis. For those with premature ejaculation, precum flooding, or premature orgasm, the sex organs start to release excessive histamine when  norepinephrine and its induced prostaglandin E2 start to heat up the brain, sex organs and noradrenergic/adrenergic/sympathetic nervous systems. Our readers' urinary analyses always showed an excess of norepinephrine and a severe deficiency of serotonin. This indicates that under the stimulation of excessive inflammatory hormone prostaglandin E2 and prolactin in sexual exhaustion conditions,  H3 fails to suppress the histamine and norepinephrine release, but  it positively and successfully block the dopamine, acetylcholine, serotonin, and GABA release in the nervous terminals. You may wonder why sexual exhaustion symptoms are complicated by the exhaustion of the hypothalamus-pituitary-adrenal and -testicular axis as well as  the destruction of the dopamine, cholinergic(acetylcholine)/vegal/parasympathetic, serotonin and GABA nervous functions, but with the excessive noradrenergic,  adrenergic, sympathetic, histaminergic or/and glutamate nervous function.
Ref:
https://www.ingentaconnect.com/content/mksg/all/2006/00000061/00000004/art00016
https://www.ingentaconnect.com/content/bsc/pse/1999/00000220/00000002/art09913
https://clincancerres.aacrjournals.org/cgi/reprint/11/19/6807
https://www.jimmunol.org/cgi/content/full/165/11/6545 
https://www.ncbi.nlm.nih.gov/pubmed/9274980?dopt=Abstract
https://ps.fass.org/cgi/reprint/86/5/843
https://www.jneurosci.org/cgi/content/abstract/23/14/5975
https://www.faqs.org/abstracts/Health/Production-of-prostaglandin-E2-induced-by-histamine-by-cloned-rheumatoid-synovial-cells.html 
https://ajpgi.physiology.org/cgi/content/abstract/242/1/G21 
https://www.jci.org/articles/view/107307/pdf 
https://www.jleukbio.org/cgi/content/abstract/74/3/420 
https://ajrccm.atsjournals.org/cgi/content/full/161/2/S1/S62 
https://ajrccm.atsjournals.org/cgi/content/full/169/1/15 
https://www.jci.org/articles/view/13930 
https://ajpheart.physiology.org/cgi/content/full/273/6/H2726
https://gut.bmj.com/cgi/content/abstract/18/6/429 
https://ard.bmj.com/cgi/content/abstract/49/7/504 
https://www.ingentaconnect.com/content/klu/428/2004/00000445/00000005/art00008 

In addition, excessive histamine stimulates excessive α-MSH release in the tissues around the eyes (dark eye circles),  scrotum, labia majors or minors, perineum, inner thighs and even nipples, leading to skin darkness known as Hyperpigmentation.  Thus, darkness of these skins indicate excessive histamine release locally. Beside excessive sex, other factors such as genetic factors, allergy, sleeping depletion (melatonin deficiency),  sickness,  and psychological stress,  can also cause excessive α-MSH release. However, high-frequency sex will darken eye circles and labia minors very fast due to its induced poor local blood circulation and overall blood color change as result of excessive norepinephrine, epinephrine, prolactin and α-MSH in the bloodstream. For more information, please go to Excessive sex for darker eye cycles, nips, labia minors, pelvic area, perineum, clitoral and penile foreskin.

By the way, excessive norepinephrine and prostaglandin E2 in the brain causes Homosynaptic and Heterosynaptic plasticity ( https://www.la-press.com/redirect_file.php?fileId=829&filename=GRSB-1-Akenaya&fileType=pdf ), that is nervous damage or alternation. Homosynaptic plasticity alternates synaptic strength that results from the history of activity at a particular synapse. For examples, norepinephrine increases the noradrenergic and sympathetic nervous fires; epinephrine increases the adrenergic and sympathetic nervous fires.  Serotonin Reuptaking Inhibitors outgrow the serotonin neurons and post-synapses and produces long-term inhibitory effects on the presynaptic terminals of the dopaminergic neurons. On the other hands, heterotropic plasticity changes synaptic strength that results for the activity of other neurons. For example, chronic norepinephrine stimulation under the noradrenergic/sympathetic nervous systems produces long-term inhibitory effects on the presynaptic terminals of neurons of the cholinergic/vegal/parasympathetic/serotonin/GABA neurons.  This is why Drug and excessive Sex are so destructive to the brain, in particular, when alcohol opens the brain-blood barriers to allow more excitatory toxins and neurohormones (such as norepinephrine, epinephrine, glutamate, histamine and prostaglandin E2) to screw up the brain and nervous systems.

Excessive sweating and Frequent Urination vs. the hypothalamic overheating and the pituitary AVP (Arginine vasopressin):
Noradrenergic, adrenergic and sympathetic nervous fires overheat the body for sweating. Sweating is to expel the internal body heat from the skin surface, and serves as a means of thermoregulation. External heat (hot weather),  muscular or joint heat, nervousness and nausea, panic responses, physical or psychological stress can cause excessive sweating. Exhaustion of the hypothalamus-pituitary-adrenal axis can cause excessive noradrenergic, adrenergic and sympathetic nervous fires and/or deficiency of AVP.   Frequent urination is a result of the excessive sympathetic nervous action on the adrenergic alpha receptors in the bladder and urethra (and prostate for men) while the vagal, serotonin and GABA nervous control are very weak.   When the AVP level is low, the fluid passes through the digestive tract, kidney and the bladder very fast by its dehydration effect. This will increase urination frequency upon fluid intake. A abrupt drop of AVP during the hypothalamic-pituitary overheating can may also trigger sudden sweating in conjunction with urinary urgency.  This is likely to occur for the drug abusers with sexual exhaustion, who serotonin and GABA nervous control on the hypothalamic dopamine-norepinephrine conversion and the core temperature regulation is out of order..

 OK,  we provide the  following topics for you, so that you can understand why sex is not for entertainment:
1. Destruction of Excessive Orgasms(for men and women) - About 5-10% of over-masturbators get permanently damaged! Over-masturbation/over-ejaculation/excessive-orgasm  can castrate your hypothalamus-pituitary-testicular(ovarian) axis by arterial constriction and inflammatory narrowness in your brain and pelvic organs (testicles, prostate, seminal vesicles, penis, ovaries, uterus, vagina and clitoris) due to excessive release of prolactin, norepinephrine, and epinephrine, excessive binding of norepinephrine/epinephrine on the alpha-adrenergic receptors, the norepinephrine/epinephrine induced excessive prostaglandin E2, and the post-sex deficiency of nitric oxide and prostaglandins E1/E3 production.  God punishes the self-destructors! Don't become one of them! Or you have to pay a high price for the consequence.
2. Male Ejaculatory Frequency and Seasonal Change vs Semen Quality
3. Male Ejaculation Frequency vs. Testosterone Level - Psychological (Sexual) Stress locks up the hypothalamus-pituitary-adrenal and testicular axis via cortisol, prolactin and inflammatory hormone prostaglandin E2
4. Semen contains human growth hormone, Insulin-like growth factor-I,  alpha2-macroglobulin, testosterone, other therapeutic and pharmaceutical proteins and a lot of prostaglandins for better (Prostaglandin E1 and E3 for healing)  or worse (prostaglandin E2 causes cancers and tumors in the prostate and cervix)
5. Sex as an Addictive Drug (but, can we retrain old dogs with new tricks to reverse addiction?)- the neuroplasticity of the hypothalamus by norepinephrine and its induced prostaglandin E2(for men and women) 
6. Excessive sex for darker eye cycles, nips, labia minors, pelvic area, perineum, clitoral and penile foreskin
7. Excessive sex and Light Over-Sensitivity in Retina
8 Benefits from Optimal Orgasms(for men and women)
9. Brain-Skin/Brain-Hair connection - the effect of excessive sex-induced stress on skin (acne) and hair (hair loss) (for men and women)
10.  Sex-stress (Norepinephrine/ Epinephrine)  induced Inflammatory Pains, Headaches and Hangover  (for men and women)-  Norepinephrine-induced prostaglandin E2 release sets the brain and body on fire for sexual arousal/orgasm and pains
11. Persistently Sexual Arousal (breeding) or Over-ejaculation (Frequent Orgasm) Reducing/Suppressing Male Immune Function via Norepinephrine Induced Prostaglandin E2 Release
12. Liver/organs malfunction and inflammation and Hypothalamus-Pituitary-Adrenal  impairement - ageing - induced by sex stress with chronic elevation of immunotransmitter cytokines and inflammatory hormone prostaglandin E2 (for men and women)
13. Stress hormones norepinephrine and epinephrine induced apoptosis in blood vessels.
14. Anxiety, Neuroimmune Reaction, and Premature Ejaculation
15. Orgasm-induced neuroimmune disorders, allergy and asthma.
16. Orgasm Brain Sex Pain examples (for men and women)

Destruction of Excessive Orgasms
After you enjoyed too many sexual orgasms and/or too much pleasure, you have likely blown your brain/nervous bioelectric circuit breaker, and may have started to deal with the Sexual Exhaustion Symptoms - the exhaustion of the hypothalamus-pituitary-adrenal/-testicular (-ovarian) axis (cases are listed in Over.htm, Over2.htm, Over3.htm, and GirlOverSex.htm) very possibly or likely including the hypothalamus-pituitary-thyroid dysfunction, and deducing/downgrading or desensitization of the androgen hormonal receptors in the hypothalamus, hippocampus and pituitary, resulting from the Nervous Excitotoxicity and Inflammation induced by excessive norepinephrine, epinephrine and glutamate (& other excitory neurohormones, for a short-term pleasure reward and the long-term dopamine depletion),  long-term excessive elevation of prolactin ( to inhibit GnRH release from the hypothalamus and therefore LH and FSH secretion from the pituitary and to directly desensitize pituitary gonadotropic cells and the Leydig cells of the testes) , and Prostaglandin E2 (the brain heater for the core temperature rise!)  At the sexual exhaustion state, the constant elevation of excessive prolactin (mimics Hyperprolactinaemia) suppress sensitivity of  prolactin-negative feedback on hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons for persistently low dopamine synthesis,  blocks the beta-adrenergic receptors and nitric oxide nervous mechanisms and promotes norepinphrine and epinpehrine binding to the alpha-adrenergic receptors for vasoconstriction and restriction of blood flow to the brain and genitals, and destroys or desensitizes the hypothalamic androgen receptors, as described in
https://jp.physoc.org/cgi/content/abstract/576/2/585 
https://cancerres.aacrjournals.org/cgi/content/abstract/65/17/7984 
https://endo.endojournals.org/cgi/content/abstract/145/12/5714  
https://endo.endojournals.org/cgi/content/abstract/148/8/4080 
https://www3.interscience.wiley.com/journal/118874269/abstract?CRETRY=1&SRETRY=0 
https://www.psy.fsu.edu/faculty/hull/D&H_review.pdf  
https://ep.physoc.org/cgi/content/abstract/91/3/603 
https://jp.physoc.org/cgi/content/abstract/557/1/307  
https://endo.endojournals.org/cgi/content/full/147/3/1195
Cutting down the brain and genital blood circulation naturally alternates the neurotransmitters and hormonal syntheses, the major brain nervous function including the dopamine, acetylcholine, serotonin, GABA, noradrenergic, adrenergic, glutamate, oxytocin, nitric-oxide(NO), vagal and autonomic nerves functions,  and the hypothalamus-pituitary-adrenal and -testicular(-ovarian) function.
The Traditional Chinese Medicine has termed the hypothalamus-pituitary-adrenal (HPA) exhaustion as "Kidney Deficiency", since the classic Chinese anatomy text assumed the tiny adrenal gland, sitting on the top of  the kidney, is a part of the kidney about 2000 years ago. The HPA exhaustion results in the erratic release of CRH (corticotropin releasing hormone), POMC (proopinomelanocortin),  ACTH (adrenocorticotropc hormone),  ß-lipotropic hormone, ß-endorphin, α-melanocyte-stimulating hormone (α-MSH),  ß-MSH, CA (catecholamines) and TSH (thyroid stimulation hormone), in response to stress, sex and environmental/dyshomeostatic stimuli.  Since skin and hair follicles also display a functional equivalent of the HPA axis, sexual exhaustion will also extensively affect your skin (for examples: darkening skins in certain areas such as eye cycles, nips, labia minors, foreskin, perineum and groins, due to excessive release or trapping of the POMC peptide α-MSH which is also an anti-inflammatory and immunomodulating hormone - anti-tissue abrasion!) and the hair (for examples: hair loss in the scalp and gray hair, but it won't grow hair in your palms although it will destroy your HPA axis.)  The explanation of the HPA, skin and hair connection are given in the following links: https://edrv.endojournals.org/cgi/reprint/21/5/457, https://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1839836&blobtype=pdf , https://www.fasebj.org/cgi/reprint/04-1968fjev1.pdf,  https://www.tufts.edu/sackler/pharmacology/faculty/theoharides/documents/TiI-brain-skin.pdf , https://physrev.physiology.org/cgi/reprint/80/3/979 , https://ard.bmj.com/cgi/content/abstract/66/suppl_3/iii52 , https://www.ncbi.nlm.nih.gov/pubmed/12576179 , https://www.fasebj.org/cgi/reprint/19/10/1332.pdf, https://www.annalsnyas.org/cgi/content/abstract/885/1/350 , and https://www.jci.org/articles/view/33508/pdf
As a result, sex is like a good investment with a bad return. When you reach the neuro-endocrine breaking point, it is like the stoke market cash leading to the great depression!! Yes,  excessive sex induces psychological and physiological disorders.

For example:
Penile sensitivity, erection, semen retention and prostate pains
https://action.love/cases/case16702.htm
His ER (Emergence Room) doctors puzzled about his UFO sexual exhaustion symptoms: dizziness, headaches, ear buzzing (inner ear or cochlea inflammation), neck stiffness, shoulders tightness and pains, sleeping disorders, fatigue, short breathing racing heart, involuntary leg jerks and hand shaking (hyperactive sympathetic nerves L1 and L2 for Parkinson symptoms with dopamine, cholinergic serotonin and GABA nervous control disorders), and water retention (too much vasopressin), as a result of chronic over-masturbation and over-ejaculation.
==> https://action.love/cases/case16084.htm
Destructive over-masturbation practices at 3-5 times a day resulted in brain fires and hydraulic shock waves, unconsciousness, panics, rapid heart beat, hypertension, short breathing, chest weird feeling urination difficulty, and frequent urination.
==> https://action.love/cases/case15882.htm
After sexually exhausting his the brain's and internal Hypothalamus-Pituitary-Adrenal (HPA) axis, he has gotten headache and felt death and exhaustion from wet dream, even once a weak. Why he felt worse on the 2nd day after ejaculation? He may have to rely on  the Cutaneous Hypothalamus-Pituitary-Adrenal (CHPA) function to assist post-ejaculation or post-orgasm recovery.
https://action.love/cases/case15761.htm
Excessive dopamine-norepinephrine/epinephrine induced excessive prostaglandin E2 production to elevate core temperature for over-heating brain, skin and hair follicles' neuro-endocrine function,  leading  to dark eyes, enlarged eye pupils, low testosterone, hot flushes, low libido,  cognitive disorders, and  speed disorders.
==> https://action.love/cases/case15821.htm
Why psychological stress (excessive norepinephrine/epinephrine) induced excessive prostaglandin E2 production to elevate core temperature for over-heating brain, skin and hair follicles' neuro-endocrine function,leading to no erection, dark eyes, enlarged eye pupils, low testosterone, low libido, erectile dysfunction,  cognitive disorders and testicular disorders for no sexual orgasm - solution
==> https://action.love/cases/case15822.htm
Chronic over-stress in war zone results in Posttraumatic Stress Disorder (PTSD), traumatic brain injury (TBI), depression, panic and erectile disorders due to serotonin/GABA neuroplasticity in hypothalamus, hippocampus and adrenal glands - Dr. Lin's proposed solution for neuroplasticity reversal.
https://action.love/cases/case15877.htm

After our 10-year case collection and research, we now understand why excessive sex and drug abuses are so destructive. We are able to zoom into the main causes:
(1).  Sex-induced excessive excitory neurohormones norepinephrine/epinephrine/glutamate/histamine production for nervous toxicity: According to a American Scientists's report - https://www.americanscientist.org/template/AssetDetailNoFrame;jsessionid=aaaaBjcbX4%0D%0AuGmh?assetId=49707),   epinephrine can easily penetrate the mouse's blood-brain barrier into the limbic system, and allow lupus-like autoantibodies to reach the amygdala, where " the antibodies bind to and overactivate certain cell receptors, eventually killing the cells through excitotoxicity."  Excessive dopamine-norepinephrine-epinephrine conversion during sexual arousal/orgasm/ejaculation will drop the dopamine level (yes, for dopamine excitotoxicity prevention and rewarding pleasure if your dopamine level is too high!) , leading to excessive pituitary prolactin release to cause testicular and ovarian disorders, and keep the stress neurohormone norepinephrine or/and epinephrine in the excitotoxicity level. Our readers also reported chronic excessive orgasm/ejaculation induced seizure, headache, migraine, blackout, allergy, asthma, eye floaters and ear ringing (tinnitus), as a result of nervous excitotoxicity induced by excessive norepinephrine, epinephrine (particularly this one), glutamate or/and histamine. Prolonged and repeated assaults on the hippocampus nerve cell structure may permanently fry your brain. (Here are the other recent research examples:
https://jcem.endojournals.org/cgi/reprint/87/9/4245
https://www.biomedcentral.com/1471-2172/5/22
https://circ.ahajournals.org/cgi/content/full/102/1/96
https://www.algonot.com/pdf/mastcellsinflammation.pdf
https://www.ionchannels.org/showabstract.php?pmid=15970488
https://www.pnas.org/cgi/reprint/103/3/678
https://www.sciencemag.org/cgi/content/abstract/174/4008/512,
https://www.pnas.org/cgi/content/full/96/12/7093
https://ajpheart.physiology.org/cgi/content/full/289/4/H1577 
https://jcem.endojournals.org/cgi/content/full/89/5/2000
https://www.anesthesia-analgesia.org/cgi/content/full/100/2/520
https://www.osti.gov/energycitations/product.biblio.jsp?osti_id=6793231, as addressed in this link-
How to kick the pornography addiction:  Reduction of the inflammatory hormone prostaglandin E2 production, Excessive epinephrine and norepinephrine induces inflammatory responses, persistent sexual arousal, and brain/nervous excitotocixity, and enhancement of the serotonin and GABA nervous modulation and control
==> https://action.love/cases/case15570.htm). 
Dopamine and glutamate are essential for sex. For healthy person, sexual stimulation elevates the dopamine and glutamate synthesis. Excessive dopamine triggers the stress hormone production and promotes the liver P450 enzymes and Monoamine oxidases (MAO) to  deamination of dopamine and stress hormones. In addition to elevating the stress hormones norepinephrine and epinephrine,  chronic excessive sexual stimulation, excessive orgasm, over-masturbation/over ejaculation, or drug abuse will result in excessive glutamate release or accumulation due to a shortage of the enzyme L-glutamic acid decarboxylase and pyridoxal phosphate in efficiently converting elevating glutamate into GABA during sex, or/and due to a shortage of the enzymes gamma-glutamylcysteine synthetase and glutathione synthetase or/and a shortage of  amino acids L-cysteine and glycine, in converting elevating glutamate into the liver detoxification promoter Glutathione.   Elevation of GABA with serotonin, norepinephrine and prolactin after sex or orgasm will trigger the pineal gland to release melatonin for sleeping and restoration;  Elevating of glutathione can reduce the formation of  oxidative toxins, such as Hydrogen peroxide (H₂O₂),  associated with oxidative injury and cellular/nervous damage.  
Hair graying is a typical example of the hydrogen peroxide (H₂O₂) damage.  According to the recent study (https://www.fasebj.org/cgi/content/abstract/fj.08-125435v1 ), accumulation of  hydrogen peroxide (H₂O₂) bleaches human gray/white scalp hair shafts for graying when methionine sulfoxide (Met-S=O) is insufficient to repair in the entire gray hair follicle. It also indicates that  hydrogen peroxide (H₂O₂) damages hair follicle melanocyte apoptosis and DNA. That is, H₂O₂-mediated oxidative stress alternate human hair color by blunting methionine sulfoxide repair.  Excessive psychological and physiological stress can interrupt the Methionine-Glutathione Transsulfuration pathway with a lack of the choline-phosphatidylethanolamin synthesis, the phosphatidylcholine synthesis-  ( https://www.ajcn.org/content/vol85/issue3/images/large/znu0030743980001.jpeg & https://www.ajcn.org/cgi/content/full/85/3/702 ).  These research results seem to support  the folk medicine approach of using eggs to shampoo the scalp for reversing gray hairs.  Stress also attack the Hair Follicle Pigmentary unit, and disable or reduce hair pigmentation while hydrogen peroxide (H₂O₂)  bleaches hair shafts or damages the follicles.  Note that a  pigment  is any colored material of plant or animal cells. https://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1201498&blobtype=pdf and https://www3.interscience.wiley.com/cgi-bin/fulltext/120756708/PDFSTART .  In some extreme cases, chronic excessive stress or drug abuse may cause the hair pigment stem cells (melanocytes) to die prematurely.
Of course, you will benefit from optimal sex and orgasm if you get a resulted elevation of both GABA and glutathione.  However,  when the liver are stressed out by orgasm, over-ejaculation, drugs, and aged/toxified by the monoamine oxidization toxins, the liver can not efficiently provide the enzyme L-glutamic acid decarboxylase and pyridoxal phosphate for glutamate-GABA conversion, leading to accumulation of glutamate in the brain/nervous systems and cerebrospinal fluid for ultimate nervous and brain destruction. ( Note that increasing the conversion of L-arginine to the inhibitory neurotransmitter agmatine can help block the action of glutamate on the NMDA receptor and acts as a neuromodulator. This is an important mechanism in preventing the harmful effects of excess glutamate. Agmatine is decarboxylated argenine. Studies shows agmatine can reverse pain induced by inflammation, neuropathy, and spinal cord injury - https://www.pnas.org/cgi/content/abstract/97/19/10584 ).

Furthermore, chronically excessive sexual arousal, over-ejaculation (overmaturbation), excessive orgasms or/and drug abuse can hyperativate the enzyme Monoamine oxidases (MAO) for dopamine-DOPAL conversion , where DOPAL stands for 3,4-dihydroxyphenylacetaldehyde.  DOPAL is a potent neurotoxin to cause Parkinson's-like brain lesions, and its resulted cognitive impairment is very similar to autism. In addition to DOPAL, norepinephine and epinephrine can be converted to 3,4-dihydroxyphenylglycoaldehyde (DOPEGAL) by MAO too. DOPEGAL has been found to trigger apoptosis and cause the loss of CNS neurons. Therefore, the synergic destructive effects of both DOPAL and DOPEGAL accelerates death of nerve cells, as seen in SIDS (sudden infant death syndrome), Alzheimer’s, Parkinson’s disease, and dysfunctional disorders of development and aging.

Overmasturbation resulted in Parkinson's symptom - restless or shivering legs and hands - due to abrupt drop of dopamine for excessive dopamine-neorepinephrine-epinephrine-DOPEGAL (3,4-dihydroxyphenylacetaldehyde) and dopamine-DOPAL(3,4-dihydroxyphenylacetic acid) conversion, leading to neurotoxicity and nervous death for no more sexual orgasm
==> https://action.love/cases/case15611.htm
https://www.jneurosci.org/cgi/reprint/19/1/456 
https://www.jneurosci.org/cgi/content/full/17/12/4849 
https://psycnet.apa.org/index.cfm?fa=main.showContent&id=1992-18831-001&view=fulltext&format=pdf 

MAO, the brain/nervous and liver enzyme,  exists virtually in all mammalian cell types, with the notable exception of the erythrocyte. Excessive monoamines such as dopamine, norepinephrine and epinephrine induced by chronic stress, excessive sexual stimulation and orgasm and/or drugs will activate the liver Cytochrome P450 and MAO for oxidization (deamination) and detoxification, as described above, in order to maintain the homeostasis of the brain and nervous function. But, unfortunately, the resulting toxins destroy or damage the local neurons or synapses. In humans, there are two types of MAO: MAO-A and MAO-B. Both are found in neurons, hypothalamus, cerebral cortex (conscious control center), cerebellar cortex, pons, medulla oblongata, substantia nigra, caudate, astroglia, skins, and skeletal muscles.  Outside the brain and central nervous system, the liver, gastrointestinal tract , adrenal glands, kidnes, heart, lungs, and placenta have about 60-90% MAO-A and 10-40% MAO-B, but, MAO-B is mostly found in blood platelets. MAO's are enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. After placenta, liver contains the highest level of MAO, followed by kidneys, adrenal glands, heart, hypothalamus, substania nigra, lungs, intestine, caudate, medulla oblongata, pons, cerebral cortex and cerebellar cortex. That is, the liver, kidneys, adrenal glands, heart,  hypothalamus and substania nigra are likely aged or damaged by the  MAO-deaminated or oxidized toxins DOPAL, DOPEGAL, hydrogen peroxide (H₂O₂) and 5-Hydroxyindoleacetic acid (5-HIAA, as discussed below) faster than the other organs, and the liver will be damaged first. 
The main substrates of MAO-A include dopamine, serotonin, norepinephrine, epinephrine, octopamine, tyramine and tryptamine; the main subtstrates of MAO-B include dopamine, phenylethylamine, -phenylethylamine (PEA),  benzylamine, MPTP (1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine),  tyramine, and tryptamine. 
MAO plays the key roles in the development of neurodegenerative disease,  including not only its putative role in converting an exogenous protoxin to a toxin, as mentioned above, but also its role in the formation of peroxides generated from the oxidative metabolism of dopamine.  MAO catalyzed deamination of dopamine to DOPAL and production of hydrogen peroxide (H₂O₂) and ammonia NH₃ depend on concentrations of dopamine within the cytoplasm. Hydrogen peroxide, if not detoxified by glutathione peroxidase, can be converted by iron-mediated Fenton reactions to toxic hydroxyl radicals ( -OH) that induce lipid peroxidation and cell death. In addition, excessive ammonia accumulation in the bloodstream, termed as hyperammonemia,  can cause the confusion and coma of hepatic encephalopathy as well as the neurologic disease.     On the other hand, MAO-A breaks down serotonin into 5-Hydroxyindoleacetic acid (5-HIAA) and steals serotonin from arylalklamine N-acetyltransferase (AANAT), resulting in depleting the melatonin synthesis. Melatonin plays the key role for the mechanisms of circadian rhythm for healing the damaged cells while 5-HIAA is responsible for the developments of certain tumors or cancers.  Graveyard workers are at risk due to hyperactivities of MAO.  Our product DeToxiA, MoodMax, ViaGrowth-IV, PinealTonin and ArgiNOx have been formulated  to help you reduce the MAO gene expression (or weaken the MAO activities in the dopamine, serotonin, norepinephrine and epinephrine nervous terminals) and hydrogen peroxide (H₂O₂)  formation, and enhance the liver urea cycle to remove ammonia NH₃ from the blood stream (that is, detoxification of the nervous system, liver and blood!)
Most recent studies also indicate there is significant positive correlations between platelet MAO activity and cortisol measures. In normal sexual activities, orgasm or ejaculation is supposed to drop the cortisol level and to elevate norepinephrine and epinephrine level. If MAO turns serotonin into 5-HIAA and depletes serotonin production during or after sex, the post-sex elevation of norepinephrine and epinephrine will activate the MAO action on the adrenal cortex for excessive cortisol elevation several hours after the cortisol drop induced by ejaculation or orgasm.  Cortisol overshooting suppresses the adrenal DHEA production and testicular function, resulting depletion of androgen hormones in the brain,  and then causes post-sex hangover,  memory loss and depression in the next few days.  Maintaining a high level of cortisol will suppress immune function, promote atherosclerosis, and damage and kill brain cells eventually.  Excessive sex, orgasm or ejaculation, or/and drug abuse for pleasure rewarding or/and sexual enhancements can let you experience both hypocortisolism and hypercortisolism in your daily life when the cortisol diurnal rhythm is disturbed or the cortisol level is too low in the certain time of a day, but becomes over-shooting in the other time.  The complicated symptoms induced by sexual practices was named as Sexual Exhaustion Symptoms by Dr. Lin, as given in https://action.love/cases/case9848.htm.

• Hypocortisolism:  an abrupt drop of cortisol with symptoms of Addison's disease symptoms and others,
  including: fatigue, muscle weakness, weight loss, vomiting, diarrhea or digestive panic responses, headache, sweating, bipolar, mood swing, OCD, and joint and muscle pains;  goiter; vitiligo; dark eye circles; darkening (hyperpigmentation) of the skin, including areas not exposed to the sun, such as groins nipples, penis, testicles, labia majors and minors, and the inside of the cheek (buccal mucosa); orthostatic hypotension; cravings for salt or salty foods due to the urinary losses of sodium. 
• Hypercortisolism: an excessive level of cortisol in the bloodstream resulting in the so-called Cushing's syndrome and others, 
  including: rapid weight gain or central obesity; moon face; excess sympathetic nervous sweating, telangiectasia (dilation of capillaries); thinning of the skin for easy bruising or inflaming, particularly in the penis, testicles, face, breasts, hands, legs and other mucous membranes;  purple or red striae ;hirsutism;  insomnia; reduced libido; impotence; amenorrhoea;infertility; euphoria; psychosis; depression; anxiety; persistent hypertension (due to cortisol's enhancement of epinephrine's vasoconstrictive effect and binding into the adrenergic alpha-2 receptors); insulin resistance (especially common in ectopic ACTH production), leading to hyperglycemia (high blood sugars) which can lead to diabetes mellitus; heart disease; hyperpigmentation, resulting from Melanocyte-Stimulating Hormone production as a byproduct of ACTH synthesis from Proopiomelanocortin (POMC); abnormal mineralcorticoid to worsen the hypertension and to hypokalemia;  gastrointestinal disturbances;  immune disorders; impairment of wound healing; osteoporosis since the cortisol suppresses adrenal, testicular and ovarian function.  
  

Semen contains a lot of proimflammatory factors such as cytokines, prostaglandin E2 and 19-hydroxy prostaglandin E2, polyamines, and histamine. Although it also have anti-inflammatory cytokines and prostaglandin E1/E3, the pro-inflammatory factors usually overpower the anti-inflammatory factors since the pro-inflammatory factors are essential to the immune suppression so that the sperms can safely pass the male ejaculation tract in the prostate and urethra, survive in the vagina and uterus,  fertilize eggs, swell endometrium,  and eventually implant the fertilized eggs in the endometrium. For men, chronically blasting  the tissues and nerves of the ejaculation tract with seminal fluids result in inflammation, immune suppression, and hypersensitivity.  The inflammatory mediators may also exert toxic effects on sperms, leading to infertility too. Refs: https://www.andrologyjournal.org/cgi/content/full/28/2/325
Prostaglandin E1and E3 are the good guys for healing and restoration, but prostaglandin E2 is the good , the bad and the ugly. Prostaglandin E2 also stimulates the cells to grow and perform multiplication, and induces orgasm and labors. Recent study suggest prostaglandin E2 in seminal plasma promote cervical cancers - 
https://jcem.endojournals.org/cgi/content/full/86/5/2243 
https://endo.endojournals.org/cgi/content/full/147/7/3356 
https://humrep.oxfordjournals.org/cgi/reprint/22/1/36.pdf 

In addition to induction of inflammations, pains, tumors and cancers, prostaglandin E2 causes premature ejaculation and anxiety by stimulating the sympathetic nerves in the seminal vesicles and prostate for more hypothalamic and adrenal norepinephrine and epinephrine production.  After sexual intercourse, the prostaglandin E2 release in the prostate, urethra, vagina, cervix and uterine will shot up for 24-48 hours. The elevation of prostaglandin E2 will skew the physical examination of the sex organs and their secretion. If you want to have a precious physical examination in your pelvic organs, you should avoid sex at least 48 hours before going to see your doctor.

Sexual or orgasm addiction is due to the nervous plasticity of the hypothalamic paraventricular nucleus (PVN) where the dopamine, acetylcholine, oxytocinergic, noradrenergic (norepinephrine), adrenergic(epinephrine), autonomic (sympathetic and parasympathetic) vagal, glutamate, NOergic, GABAergic and serotonin  nervous system innervate. The nervous plastic remodeling occurs under a frequent oxytocin, prostaglandin E2 (https://ajpregu.physiology.org/cgi/content/full/294/4/R1294) and norepinephrine stimulation during sex when the GABAergic and serotonin nervous function are too weak to modulate the dopamine-norepinephrine conversion and the noradrenergic nervous firing. The main source of  noradrenergic innervations of higher brain sites, including the hypothalamus and PVN, is the locus ceruleus (LC) where norepinephrine activates pro-inflammatory pyrogenic cytokins and protein kinases in LC  for prostaglandin E2 which,  in conjunction with action of oxytocin, let you feel high, arousing and exciting. Sex can increase the density of PVN dopamine beta-hydroxylase immunoreactivity (DBHir), so that the enzyme dopamine beta-hydroxylase can constantly convert dopamine to norepinephrine to keep on sexual fire, leading to addiction. Prostaglandin E2 is involved in the regulation of synaptic activity, transmission and plasticity, and in brain evolution. Prostaglandin E2 accelerates neuroplasticity.  You need prostaglandin E2 for neuroplasticity - learning, memory and addiction. Thus, you have to study hard (for more norepinephrine and prostaglandin E2)  to memorize contents of the books you read  in a short time. However, you use them (norepinephrine and prostaglandin E2)  for sex addiction, you will love sex more than your life.  Prostaglandin E2 can also degrade the short time memory and spatial navigation by enhancing membrane excitability and then inducing long-term synaptic plasticity in hippocampal perforant path-dentate gyrus synapses.
Ref: https://www.jneurosci.org/cgi/content/full/25/43/9858 
https://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2292143&blobtype=pdf 
https://www.nature.com/nm/journal/v7/n4/full/nm0401_414.html
https://ajpgi.physiology.org/cgi/content/full/277/1/G79  
https://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1430829 
https://jn.physiology.org/cgi/content/full/88/1/49 
https://ajpheart.physiology.org/cgi/content/full/291/6/H2847 
https://ajpheart.physiology.org/cgi/content/full/274/4/H1284 
https://ep.physoc.org/cgi/content/full/90/2/169 
https://www.jneurosci.org/cgi/content/full/24/35/7604/ 
https://physiologyonline.physiology.org/cgi/content/full/14/3/100 
https://ajpregu.physiology.org/cgi/content/full/292/4/R1717 
https://endo.endojournals.org/cgi/content/full/145/11/4917 
https://joe.endocrinology-journals.org/cgi/content/full/190/3/593 
https://www.acnp.org/g4/GN401000155/Default.htm and https://jn.physiology.org/cgi/content/abstract/87/6/2851?ijkey=5cee184dd3946b4945f9cc00585dec35e2d51349&keytype2=tf_ipsecsha 

Excessive Sex for dark eye cycles, nips, labia minors, pelvic area, perineum clitoral/penile forskin:   Skin is a neuroendocrine organ. Chronic stimulation of sex organs can lead to over-production of α-MSH and Trapping excessive α-MSH in certain areas of skin results in extra skin darkness, particularly in eye cycles, nips, labia minors, penile and clitoral foreskin, and perineum if the local skin neuroendocrine function was working, but the local blood circulation becomes poor due to excessive noepinephrine or epinpehrine binding in the sympathetic andrenergic-α2 receptors of the blood vessels or a lack of nitric oxide and prostaglandins E1/E3 in the local tissues. Over-ejaculation, high-frequency sex or/and excessive orgasm causes excessive histamine release; histamine, in turn, stimulates α-MSH release from the pituitary in an attempt to counterbalance the histamine level and counteract the histamine-induced inflammatory and allergic responses.  Thus, excessive sex results in excessive histamine, prostaglandin E2 and α-MSH release.  α-MSH stimulates excessive production of melanin, a brown pigment manufactured by certain cells in the skin called melanocytes, from tyrosine. Excessive melanin is responsible for dark skin color. This is called Hyperpigmentation. The dark skin as a result of chronically excessive sex-stress norepinephrine induced inflammatory hormone prostaglandin E2 stimulation is considered as Post-inflammatory hyperpigmentation. In this regard, the excess melanin is produced in the upper layer of skin (epidermis). The cells that normally produce brown pigment evenly across your skin go into overdrive and produce too much melanin. Then,  the pigmentation color is a darker shade of brown.
https://www.fasebj.org/cgi/content/full/21/4/976 
https://physrev.physiology.org/cgi/content/full/80/3/979
https://edrv.endojournals.org/cgi/content/full/21/5/457  
The tissues also around the eyes contain a high level of COX enzyme receptors, histamine receptors,  and master cells .  You will feel itchiness and allergy-like responses in your eyes.  Due to the constriction of the arteries and veins, melanin is trapped around the eye cycles leading to darkening of eye cycles.  This also happens in your groins area too.  Generally,  the skin in a poor blood circulation area, even if there is no UV exposure,  becomes darker than the other areas.  
Although melanin is a skin and hair protector,  over-production of melanin signals sexual exhaustion and reduces dopamine and oxytocin synthesis as a self regulation of libido, thus,  to slow down libido. However, in the brain,  overloading of neuro melanin (also known as neuromelanin) in in the substantia nigra pars compacta  is an increased contribution to oxidative stress and intraneuronal damage in patients with Parkinson's disease, resulting in degeneration of dopaminergic neurones. https://www.ingentaconnect.com/content/bsc/jnc/2003/00000086/00000005/art00009,
https://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1187132&blobtype=pdf 
Does this concludes that the excessive sex, besides ageing and drug uses,  leads to restless leg syndromes or parkinson's disease?
Genetic factors also play the important role in α-MSH and melanin release and the distribution of melanin in cells over the body.

The epidermis is avascular, nourished by diffusion from the dermis, and composed of four cell types: keratinocytes, melanocytes, Langerhans cells, and the Merkels cell.  Melanocytes  is responsible for  pigmentation.  Similar to paint or ink, skin color is a result  of mixing four biochromes: oxyhemoglobin (red), reduced hemoglobin (blue), carotenoids (yellow) and, melatonin (brown).  The amounts and types of melanins produced and their distribution vary in the skin, responding to α-MSH, blood circulation, and internal or external stimulus including VU, drugs and mechanic/abrasive stimulation. Different body parts have melanocyte density. For example, the palms and soles contain less melanocytes while nipples have higher. For some people, the eye circle tissues and groins also contain a high density of melanocyte than the other areas do.  Melanocytes are cells located in the bottom layer (the stratum basale) of the skin's epidermis, hair follicles, the middle layer of the eye (the uvea, the pigmented middle of the three concentric layers that make up an eye), the inner ear,  meninges,  bones and heart.  In the skin, melanocytes comprise from 5% to 10% of the cells in the basal layer of epidermis while keratinocytes is the major constituent of the epidermis, constituting 90% to 95% of the cells in epidermis.  Melanin is synthesized and stored in membrane-bound organelles (termed melanosomes) where melanosomes form a critical barrier, a protection layer, to shield DNA from external stimulus such as ultraviolet radiation or external drug and mechanical stimulation   As melanosome grows to neighboring keratinocytes,  the protection layer expands as proliferating keratinocytes in the suprabasal epidermal layers.  As a result, the local skin becomes darker. 
Recent studies shows glutathione, glycine, L-alanine, L-isoleucine and L-leucine can inhibit melanin synthesis in the reaction of trysinase and L-dopa.  OurViaGrowth-IV contains glutathione, glycine and L-alanine, as well as L-tyrosine
Ref: https://www.ncbi.nlm.nih.gov/pubmed/18670186
https://www.jstage.jst.go.jp/article/bpb/30/4/677/_pdf
https://www.jstage.jst.go.jp/article/bpb/30/11/2031/_pdf
https://endo.endojournals.org/cgi/reprint/146/2/532
and https://www.fasebj.org/cgi/content/full/20/7/882 
https://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2678743&blobtype=pdf 
Garland CF, et al. Epidemiologic evidence for different roles of ultraviolet A and B radiation in melanoma mortality rates. Ann Epidemiol. 2003; 13(6):395–404.
https://www.ncbi.nlm.nih.gov/pubmed/12875796
Wolf P, et al. Effect of sunscreens on UV radiation-induced enhancement of melanoma growth in mice. J. Natl Cancer Inst. 1994; 86 (2):99–105.
https://www.ncbi.nlm.nih.gov/pubmed/8271307 
Tadokoro T, et al. UV-induced DNA damage and melanin content in human skin differing in racial/ethnic origin. Faseb J. 2003;17(9):1177–1179. https://www.fasebj.org/cgi/reprint/02-0865fjev1
Yamaguchi Y, et al. Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation. J. Cell Biol. 2004; 165 (2):275–285.
https://jcb.rupress.org/cgi/content/full/165/2/275 
Montagna W, Carlisle K. The architecture of black and white facial skin. J Am Acad Dermatol. 1991;24(6Pt 1):929–937.
https://www.ncbi.nlm.nih.gov/pubmed/1714469
Galus R, Zandecki Ł,Sajjad E, Jóźwiak J, Włodarski K. Factors affecting melanogenesis and methods used for identification of pigmentation disorders, Pol Merkur Lekarski. 2008 Aug;25(146):188-91 https://www.ncbi.nlm.nih.gov/pubmed/18942345?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=5&log$=relatedreviews&logdbfrom=pubmed 
Special Note:
from https://en.wikipedia.org/wiki/Melanin: The photochemical properties of melanin make it an excellent photoprotectant. It absorbs harmful UV-radiation and transforms the energy into harmless amounts of heat through a process called "ultrafast internal conversion". This property enables melanin to dissipate more than 99.9% of the absorbed UV radiation as heat^[3] and it keeps the generation of free radicals at a minimum (see photoprotection). This prevents the indirect DNA damage which is responsible for the formation of malignant melanoma.

Melanin in the eyes, in the iris and choroid, is supposed to adjust and darken the their color to filter out ultraviolet and high-frequency visible light.  There are two layers in the iris: the front pigmented fibrovascular tissue, also known as stroma, and,  behind the stroma, pigmented epithelial cells. The stroma connects to the iris sphincter muscle responsible for adjustment of the pupil in response to light intensity.  Strong light constrict the pupil for limiting the rays.A wide pupil results in an image that is sharp around what the iris is focusing on and blurred otherwise  The back surface of the stroma is covered by a heavily pigmented epithelial layer, the iris pigment epithelium which release melanin in response to light. The higher the pigment content is, the more light from passing through the iris to the pupil is attenuated.  This light filtration mechanism relies on the release of melanin.  Since L-Ddopa  is the immediate precursor of melanin,  If there is a deficiency of L-dopa, this optical filtration will be malfunctioning. If sexual arousal or orgasm turns too much L-Dopa  into dopamine and then norepinephrine and epinephrine,   the L-Dopa will drop too low to support the iris and choroid pigmentation in response to light. As a result, your visual receiving sensors will become hypersensitive to light, in addition to experiencing  UV damage 

Melatonin is the main regulator of light sensitivity by many ways.  Melatonin is responsible for photomechanical movement, cone photoreceptor elongation and rod photoreceptor contraction,  as the adaptation to decreasing light intensity which increases melatonin release. The photosensitivity of the receiving circuits increases in the weak light to compensate the weak visibility,  so that the visual perception can become clearer.  The opposite photomechanical adjustment occurs in response to increasing light intensity and the resulted increase of dopamine in the central nervous system and retina.  The dopamine release in the retina increases after light exposure and decreases in darkness. Melatonin suppresses the light-elicited dopamine release from retina, as photoreceptor adaptation to darkness.  That is, we can say:  melatonin is the darkness hormone while dopamine is the light hormone.  The photosensitivity of the receiving circuit decreases as dopamine increases, as a feedback control of the visual circuit , so that there is no truncation of visual signals entering the visual cortex. When the dopamine level is too low, the retinal receiving circuit become too sensitive to light. In particular, the eye pupils are dilated by the norepinephrine/sympathetic nervous function.  Excessive hypothalamic and adrenal dopamine-norepinephrine conversion can cause this problem.
Melatonin, synthesized in the retina also modulates the retinal pigment epithelium (RPE) function by aggregating pigmented cells in the RPE and choroid of the eye.  Thus, the another way for melatonin to regulate the amount of light entering the photoreceptor is to control the movement of melanosome granules within the RPE where melanosome granules stores melanin. Eye pigmentation of releasing melanin in response to light attenuates the light intense before entering the retina.  Melatonin can also alter the electrical activity of the RPE of the mammalian eye.  https://www.pubmedcentral.nih.gov/picrender.fcgi?artid=286629&blobtype=pdf
Glutamate, the darkness neurotransmitter,  in the retinal receiving circuit modulate the visual response to the light by decreasing its concentration. When the eyes abruptly expose to the light, it will take a while to turn on the color receiving circuit by removing glutamate. Unfortunately, dopamine and glutamate are essential to sexual arousal and orgasm. During orgasm and in the pos-orgasm state, excessive glutamate is supposed to turned into GABA, 5-HTP to serotonin, and dopamine to norepinephrine,  resulting in elevation of melatonin to suppress dopamine synthesis. In some cases, glutamate won't turn to GABA or/and dopamine drops too low, leading to eye floaters, light-oversensitivity in retina, and of course, depression and brain fog

MCCORMACK, C. A., AND B. BURNSIDE. A role for endogenous dopamine in circadian regulation of retinal cone movement. Exp. Eye Res. 55: 511-520, 1992, https://www.ncbi.nlm.nih.gov/pubmed/1426081?dopt=Abstract 
PIERCE, M. E., AND J. C. BESHARSE. Circadian regulation of retinomotor movements. I. Interaction of melatonin and dopamine in the control of cone length. J. Gen. Physiol. 86: 671-689, 1985, https://jgp.rupress.org/cgi/reprint/86/5/671?ijkey=5a59ef7104c09f319b0af034572dfae5ea9180b7 
STENKAMP, D. L., P. M. IUVONE, AND R. ADLER. Photomechanical movements of cultured embryonic photoreceptors: regulation by exogenous neuromodulators and by a regulable source of endogenous dopamine. J. Neurosci. 14: 3083-3096, 1994 , https://www.jneurosci.org/cgi/reprint/14/5/3083?ijkey=5c1cba68d6e6d7db8ff1f6eb91514ceedcf544fd 
THALER, C. D., AND L. T. HAIMO. Regulation of organelle transport in melanophores by calcineurin. J. Cell Biol. 111: 1939-1948, 1990, https://jcb.rupress.org/cgi/reprint/111/5/1939?ijkey=0c6f309ff96292b90ee0f74dd0d48ff9168e08de 
PANG, S. F., AND D. T. YEW. Pigment aggregation by melatonin in the retinal pigment epithelium and choroid of guinea-pigs, Cavia porcellus. Experientia 35: 231-232, 1979.
KEMALI, M., N. MILICI, AND D. KEMALI. Melatonin and LSD induce similar retinal changes in the frog. Biol. Psychiatry 21: 981-985, 1986 
NAO, I.. N, S. E. NILSSON, R. P. GALLEMORE, AND R. H. STEINBERG. Effects of melatonin on the chick retinal pigment epithelium: membrane potentials and light-evoked responses. Exp. Eye Res. 49: 573-589, 1989, https://www.ncbi.nlm.nih.gov/pubmed/2806426?dopt=Abstract 
WITKOVSKY, P., S. STONE, AND J. C. BESHARSE. Dopamine modifies the balance of rod and cone inputs to horizontal cells of the Xenopus retina. Brain Res. 449: 332-336, 1988, https://www.ncbi.nlm.nih.gov/pubmed/3293703?dopt=Abstract 
WIECHMANN, A. F., X. L. YANG, S. M. WU, AND J. G. HOLLYFIELD. Melatonin enhances horizontal cell sensitivity in salamander retina. Brain Res. 453: 377-380, 1988, https://physrev.physiology.org/cgi/external_ref?access_num=3401776&link_type=MED 
BESHARSE, J. C., AND P. M. IUVONE. Is dopamine a light-adaptive or a dark-adaptive modulator in retina? Neurochem. Int. 20: 193-199, 1992.
BESHARSE, J. C., AND D. A. DUNIS. Methoxyindoles and photoreceptor metabolism: activation of rod shedding. Science 219: 1341-1343, 1983, https://physrev.physiology.org/cgi/ijlink?linkType=ABST&journalCode=sci&resid=219/4590/1341  
TEXTORIUS, O., AND S. E. NILSSON. Effects of intraocular irrigation with melatonin on the c-wave of the direct current electroretinogram and on the standing potential of the eye in albino rabbits. Doc. Ophthalmol. 65: 97-111, 1987, https://www.ncbi.nlm.nih.gov/pubmed/2444402?dopt=Abstract 
DUBOCOVICH, M. L.. Melatonin is a potent modulator of dopamine release in the retina. Nature 306: 782-784, 1983 https://www.ncbi.nlm.nih.gov/pubmed/6656879?dopt=Abstract  
KAZULA, A., J. Z. NOWAK, AND P. M. IUVONE. Regulation of melatonin and dopamine biosynthesis in chick retina: the role of GABA. Vis. Neurosci. 10: 621-629, 1993, https://www.ncbi.nlm.nih.gov/pubmed/8101728?dopt=Abstract 
BOATRIGHT, J. H., M. J. HOEL, AND P. M. IUVONE. Stimulation of endogenous dopamine release and metabolism in amphibian retina by light- and K⁺-evoked depolarization. Brain Res. 482: 164-168, 1989 ,https://www.ncbi.nlm.nih.gov/pubmed/2706474?dopt=Abstract

As of today,  a high level of prolactin has been realized as a promoter or co-initiator of breast and prostate cancers, in addition to disable the sexual function. It appears to play a key role in the development and progression of breast and prostate cancer and tumors.  So, keep your prolactin level in the normal range and avoid the synergistically biological effects of the prolactin on the estrogen or/and DHT receptors.

You will get another benefit from sex and orgasm if you get a resulted elevation of both GABA and glutathione which are converted from excitototoxicity glutamate. GABA is synthesized from glutamate using the enzyme L-glutamic acid decarboxylase and pyridoxal phosphate as a cofactor, and glutathione from the amino acids L-cysteine, L-glutamate and glycine in two adenosine triphosphate-dependent steps:   by combining L-glutamate and cysteine via the enzyme gamma-glutamylcysteine synthetase to form gamma-glutamylcysteine, and then adding glycine to gamma-glutamylcysteine via the enzyme glutathione synthetase to produce glutathione. Elevation of GABA with serotonin, norepinephrine and prolactin after sex or orgasm will trigger the pineal gland and retina to release melatonin for better sleeping, hGH production, nervous regrowth, neuro-endocrine restoration, cellular repair,  and shaper vision;  Elevating of glutathione can reduce the formation of  oxidative toxins, such as Hydrogen peroxide (H₂O₂),  associated with oxidative injury and cellular/nervous damage.  However, if you lack of these liver enzymes ( L-glutamic acid decarboxylase, pyridoxal phosphate , gamma-glutamylcysteine synthetase and glutathione synthetase)  and amino acids L-cysteine and glycine, you will get excitotoxicity and brain/nervous damage from your orgasm sponsoring neurotransmitters glutamate, dopamine, norepinephrine, epinephrine and histamine which stimulate the gene over-expression of monoamine oxidase in your brain, liver, kidneys, adrenal glands, heart and other organs for premature ageing, brain and nervous damage,  and sexual exhaustion symptoms (as listed in https://action.love/cases/case9848.htm).

Sexual arousal, ejaculation or orgasm induces a burst of norepinephrine and epinephrine release.  For a health person, the norepinephrine and epinephrine release is supposed to stop in few minutes after sex and drops in maintaining the homeostasis. Overall, the norepinephrine and epinephrine level will stay higher for few hours.  Norepinephrine and epinephrine can trigger both proinflammatory and anti-inflammatory cytokines and kinases in the immune system via the stimulation of the alpha- and beta-adrenergic receptors.   Moderate increase in norepinephrne and epinephrine during and fater sex results in increase in the concentration of lymphocytes in the bloodstream for immune enhancemen; t and the anti-inflammatory cytokins overpowers the side effects produced by proinflammatory cyrockins.  That is why optimal sex, like moderate exercises, can improve your health and neuroimmune function. However, excessive norepinephrine induces more proinflammatory effects than anti-inflammatory ones, leading to excessive prostaglandin E2 production to set your brain and body on fire - over-heating, immune disorder and inflammatory responses. This is what you have to concern about.

My case collection since 1997 is given in
https://action.love/extra/acne.htm and
https://action.love/extra/hailoss.htm 
My intention is to have a statistical data (cases) to support the traditional Taoism's and Chinese Medical claims about the side effects of over-sex on the acne outbreak and hair loss. In the past, there have been a lot of disputes on this issue (for example, please read https://answers.yahoo.com/search/search_result;_ylt=AlClvcr4x7agkfBvF65HS6Hpy6IX;_ylv=3?p=over+masturbation ).  Luckily, I also have found the scientific research support on these claims. Scientifically, it is called the skin's and hair-follicle's hypothalamus-pituitary-adrenal axis or the skin/hair stress response axis - the response of the body to acute and chronic stress induced by temporarily or chronic over-sex activities. Under acute or chronic stress, neurohormones, neurotransmitters, neuropeptides and neurotrophins will stimulate a series of adaptation responses, leading to behavioral, cardiovascular, metabolic, endocrine and immunological changes. The most critical one is the immunological changes ranging from immune suppression to imflammation. Acne, skin allergy,  and hair loss can be considered as a result of inflammatory diseases. In fact,  psychological stress causes more inflammatory and autoimmune diseases than what you think. I have termed the resuted diseases as the Sexual Exhaustion Symptoms  if they are directly or indirectly induced by sex-induced stress - chronic or acute! If you still don't understand why excessive stress induces acne and hair loss, you should read the following links-
https://edrv.endojournals.org/cgi/reprint/21/5/457 ,
https://www.fasebj.org/cgi/reprint/04-1968fjev1,
https://edrv.endojournals.org/cgi/reprint/21/5/457,
https://www.psychosomaticmedicine.org/cgi/reprint/63/3/412,
https://www.tufts.edu/sackler/pharmacology/faculty/theoharides/documents/TiI-brain-skin.pdf,
https://edrv.endojournals.org/cgi/reprint/22/4/502,
https://www.fasebj.org/cgi/reprint/19/10/1332,
https://ajp.amjpathol.org/cgi/reprint/165/1/259,
https://www.nature.com/jid/journal/v122/n1/pdf/5602146a.pdf,
https://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1868107&blobtype=pdf
and https://www.nature.com/jid/journal/v117/n2/pdf/5601158a.pdf

Excessive sex, drug/alcohol abuse, work overloads,  Over-eating (high-protein overdosing and high-tyramine foods), excessive caffeine intake, and excessive exercises can induce excessive stress hormone production for hair loss (actually, stopping hair regrowth after losing hair)  and acne outbreak - the sympathetic nervous fires in your skin and hair follicles. Sleeping disorders indicate excessive stress with insufficient serotonin and GABA nervous modulation on the pineal and retinal function.  Your acne and hair loss can also be associated with sleeping disorders.

IL-1, IL-1ß

TNF-

At the same time, the adrenal medulla also release norepinephrine and epinephrine into the bloodstream  in response to sexual stimulation and orgasm.  Norepinephrine reach all the alpha and beta adrenergic receptors everywhere in the body, where the local tissues, under the norepinephrine stimulation, release postaglandin E2 into the bloodstream or for exciting the local sensory nerves. When a local tissue won't produce enough prostaglandin E1 and endorphin or have a weak serotonin and GABA nervous modulation and control on the nervous stimulation by prostaglandin E2, the local nerves will be inflammatory with tingling, pains,  cramps, allergy, or other nervous reaction symptoms, such as frequent urination, incontinence, peeing urgency without a full bladder, and premature ejaculation.  Similarly, sex organ under the norepinephrine action on sympathetic nervous beta-and alpha-andrenergic receptors can release excessive prostaglandin E2 release too.   Please note: the binding of norepinephrine in the alpha-adrenergic receptors will give your erectile dysfunction or let your penis or clitoris and G-spot go limp while the excessive norepinephrine-induced prostaglandin E2 produces premature orgasm, premature ejaculation, precum  or semen leakage, excessive vaginal wetness, inflammatory headaches or migraines, inflammation-induced vision and hearing disorders (inflammatory eyeballs and inner ears), and pains in your sex organs, stomach, neck,  joints or/and muscles.  (special ref:  https://www.iovs.org/cgi/reprint/22/6/757 for the inflammatory iris-ciliary body of eyes, and https://www.iovs.org/cgi/reprint/15/2/102 )

Mechanical stimulation on sex organs (actually, any skin tissues) can also trigger the cutaneous neuro-immino-endocrine function and induce norpeinephrine and prostaglandin E2 release from the local cells without the central hypothalamus-adrenal action, so that the stimulation signal can be amplified as EPSPs and then coupled into the postsynaptic neurons for the sensory relay to the brain and central nervous system. Once stimulation signal reaches the brain, it can turn on the central neuro-immno-endocrine action from the hypothalamus-pituitary-adrenal and -testicular axis.

It should be noted that sexual arousal and orgasm requires testosterone and dopamine to sensitize the LC and POA nervous sensitivity, to promote the dopamine-norepinephrine conversion for induction of the sympathetic nervous fires and prostaglandin E2 release, and to stimulate the oxytocin release from the pituitary.  Testosterone is the fuel of sex, dopamine is the lighter, and norepinephrine is the fire. However, we can not ignore the effect of the 5-alpha testosterone metabolite, DHT, on sexual function.  Blocking testosterone-DHT conversion will also reduce courtiship, sex organ erectile function and size, and male semen production and quality. DHT acts to increase survival of penile musculature followed by survival of spinal nucleus of the bulbocavernosus (SNB), whose motoneurons innervate perineal muscles involved in copulatory reflexes.  In the adult, DHT also affects the morphology of SNB neurons, the growth of cell bodies and dendrities, and the penile/clitoral/G-spot size during erection when binding of DHT into its receptors. The motoneurons innervate the bulbocavernosus (BC) and levator ani (LA), in striated skeletal muscles that attach to the base of the penis (and maybe, clitoris too.)  The motoneurons also innervate the external anal sphincter for both sexes. Deficiency of DHT will induce inflammatory pains, with prostaglamndin E2 release,  in the pelvic floor (perineum), penis, testicles, vagina, vulva, and anus,  and cause Interstitial Cystitis (IC). Excessive DHT will over-expand the local tissues for pains too.
Ref:  https://www.msu.edu/~breedsm/pdf/JCN2004ARinMuscle.pdf,
https://www.ingentaconnect.com/content/bsc/jneur/2007/00000019/00000010/art00010,
https://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=91005
https://content.karger.com/ProdukteDB/produkte.asp?Doi=48115  
https://jcem.endojournals.org/cgi/content/abstract/79/2/409
https://endo.endojournals.org/cgi/reprint/136/4/1495 
https://cat.inist.fr/?aModele=afficheN&cpsidt=14669477 
https://www.andrologyjournal.org/cgi/reprint/26/2/242.pdf 
https://www.mindfully.org/Pesticide/Alligator-Penis-Apopka-Guillette.htm 
https://www.reproduction-online.org/cgi/content/full/133/2/331 
https://www.blackwell-synergy.com/doi/pdf/10.1111/j.1008-862X.2005.00003.x 
https://www.ncbi.nlm.nih.gov/pubmed/11845321?dopt=Abstract 
https://humupd.oxfordjournals.org/cgi/content/abstract/7/3/314?ijkey=99f7484e2eaccb186ea17615366f70e2a7798679&keytype2=tf_ipsecsha 
https://www.ncbi.nlm.nih.gov/pubmed/2177574?dopt=Abstract 
https://www.bch.msu.edu/~zacharet/publications/pdf/Rosen-JNeuroEndo14(1)19-28,2002.pdf, https://www.medscape.com/medline/abstract/9212065  and https://endo.endojournals.org/cgi/content/full/147/5/2392 

Excessive Prostaglandin E2 also suppresses the the neuroimmune and inflame your internal organs and joints for functional disorders, and let you get infection, allergy and sinus,  and catch cold easily, and experience arthritis and Chronic Fatigue Immune Deficiency Syndrome (CFIDS.) When your core temperature rises due to the action of prostaglandin E2 on the brain, you only feel over-heating and sweating for unknown reasons (even in a cool or cold condition), but also are very easy to get sick or catch cold. Particularly, you may become very hot and sweating due to the brain overheating, and then if you feel chilly after sex, you can be in trouble.
Note that rheumatoid arthritis (RA) is an inflammatory disorder with characterization of systemic and local inflammation resulting in cartilage and bone destruction.  Prostaglandin E2 can be linked to the edema and the erosion of cartilage and juxta-articular bone.  Reducing the stress-induced  prostaglandin E2 production and increasing the prostaglandin E1 and endorphin production by improving the hypothalamus-pituitary-adrenal and -testicular/ovarian function can resolve both the signs and levels of inflammation.  Therefore, reduction excessively sex-induced and other psychological stress is the way to prevent the decay of the joints.  Ref: https://www.pubmedcentral.nih.gov/picrender.fcgi?artid=151107&blobtype=pdf 

The other problems associated with excessively norepinephrine-induced prostaglandin E2 are ejaculation/orgasm induced sleeping disorder and persistent sexual arousal.  It is like your body on fire.  The persistent sexual arousal and orgasm/ejaculation urgency are due to excessive prostaglandin E2 stimulation on the seminal vesicles, prostate, bulbourethral glands, penis, kidneys and bladder for men,  and the uterus, G-spot, vagina and clitoris for women. This means the norepinephrine-induced prostaglandin E2 over-excited your pineal gland and retinal and cut down your melatonin production,  inflamed your eye balls and sex organs,  and over-dilated your eye pupils, prostate, penis, G-spot and clitoris.

It is also found out-of-bounded hormones, such as DHEA (that may produce a high level of testosterone, although an extremely high DHEA won't directly cause inflammatory responses, according to this report- https://jcem.endojournals.org/cgi/reprint/83/6/2012.pdf ), testosterone, DHT, LH, FSH, estrogen, and progesterone  will also induce prostaglandin E2 production.  The menopause symptoms, hot flushes, overheated brain and spine,  body pains, sweating, insomnia, are the typical examples. This is a result of excessive LH-induced prostaglandin E2 release. It can happen to young men and women who have excessive sex or the exhausted hypothalamus-pituitary-adrenal/-testicular(-ovarian) function although it is common for middle-age men and women, even without having sex.  The overshooting of the pituitary LH hormone responds to deficiency of testosterone (and DHT) and estrogen/progesterone, for  men and women, respectively, several hours or days after sex, when the serotonin and GABA nervous modulation are too weak.  After ejaculation or orgasm, norepinephrine and its induced prostaglandin E2 remain very high in keeping your brain and sex organs in heat, while the orgasm-induced cortisol and  prolactin release will continue for several hours or days and will become high enough to block the testosterone or estrogen/progesterone production from the testicles and ovaries, respectively. In this case, the pituitary gland will continue to fire up LH in an attempt to increase testosterone and estrogen production to cool down the negative dopamine-hypothalamus-pituitary-testicular/ovarian hormonal control loop.  Excessive LH release, in turn,  elevates the prostaglandin E2 in the brain and spinal fluid for hot flashes and core temperature rise- the menopause symptoms for men and women.  This results in sleep disorders, sweating, pains, losing memory or concentration, even headaches or hangover. In this regard, you will need ViaPal-hGH-M or ViaPa-hGH-E to turn off  the negative dopamine-hypothalamus-pituitary-testicular/ovarian hormonal control loop for a good sleep.

Although norepinephrine is the main contributor to both inflammatory and neuropathic pains. These pain states can be sensitized with increase in  the norepinephrine-epinephrine conversion in the adrenal medulla and the sympathetic nervous neuromuscular endings via the stimulation of epinephrine on the adrenergic beta receptors.  Sexual arousal and orgasm/ejaculation ultimately elevate the plasma concentrations of epinephrine as a final stage of the catecholamines metabolism from dopamine.  With  oxytocin  and prostaglandin E2 stimulation,  epinephrine produces a -adrenergic receptor-mediated mechanical  hyperalgesia for a swelling, hypersensitive penis, clitoris and G-spot upon orgasm or ejaculation. The sex organs can become too sensitive to touch or couple minutes after orgasm or ejaculation. At some extreme swellings cases,  orgasm-induce excessive norepinephrine-epinephrine conversion result in shooting pain in the brain, stomach, low back, low abdomen, tailbone, testicles, prostate, uterus, penis, and vagina.  In some cases, the brain arteries are inflamed and  restricted so much that the brain blood flow is nearly cut off, resulting in  blackout or seizure orgasm responses or little death.  

Researches have found that epinephrine induces cutaneous mechanical hyperalgesia and sensitizes the dorsal root ganglion neurons via its action at a -adrenergic receptor and the effects of epinephrine are enhanced by both the inflammatory protein kinases A and  C second-messenger pathways.  Ref:  https://jn.physiology.org/cgi/content/full/81/3/1104 

and testis (yes, sperm cells contain GABA receptors, important to male fertility). GABA is locally synthesized and stored by steroid-producing cells of the adrenal cortex, possibly forming an auto- or paracrine GABAergic system,  and may influence these cells in cortisol and DHEA synthesis. In addition to hormonal control by the circulating hormones ACTH and angiotensin II, a wide variety of other hormones, neuropeptides, neurotransmitters, and cytokines participate in the control of adrenal function. These substances originate from the adrenal medulla, neurons, vascular cells, and immune cells. GABA and functional GABA_B receptors have been detected in peripheral tissues such as adrenal medulla, islets of Langerhans, placenta, and smooth muscle cells of the airway, urinary bladder and uterus, responsible for control of norepinephrine and epinpephrine release from adrenal medulla, relaxation of smooth muscles, and mitigation of blood vessel constrictive and inflammatory effects via the alpha-adrenergic receptors.
https://www.ncbi.nlm.nih.gov/pubmed/6237538?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_RVAbstractPlusDrugs1 
https://ajplung.physiology.org/cgi/content/abstract/291/5/L923 
https://ajplung.physiology.org/cgi/content/abstract/294/6/L1206 
https://pats.atsjournals.org/cgi/content/abstract/5/1/47 
https://ajplung.physiology.org/cgi/content/full/291/5/L923
https://www.ncbi.nlm.nih.gov/pubmed/16343781?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=5&log$=relatedarticles&logdbfrom=pubmed and
https://endo.endojournals.org/cgi/content/abstract/145/5/2402 

9. Both GABAergic and Serotoninergic neurons modulate the cleavage of Pro-OpioMelanoCortin (POMC) into ACTH  and β-lipotropin (β-LPH) in the anterior pituitary gland; Corticotropin-like intermediate peptide (CLIP), γ-LPH, α-MSH , γ-MSH, β-MSH and β-endorphin in the intermediate lobe; MSH, by POMC neurons in the arcuate nucleus of the hypothalamus.  α-MSH released into the brain by these neurons has effects on feeding behavior, energy expenditure, and sexual arousal; α-MSH released into the blood stream or synthesized by skin cells or hair folliclesm, under action of UV or genes, will darken the skin and hair color respectively.  α-MSH stimulates oxytocin (OT) release from dendrites of the magnocellular neurons in conjunction with action of dopaminergic neurons on D2 receptors while blocking "normal" OT release at the axonal release sites. This helps the brain turn on the sexual libido and erectile circuits. Serotoninergic and GABAnergic( with Chloride-dependent Calcium Channel Activation) nervous system modulate the entire hypothalamus-pituitary-adrenal axis and reduce the ACTH release or action while increasing endorphin,  MSH and lipotropin.
https://www.uco.es/investiga/grupos/endocelular/papers-pdf/Peptides-Regulation%20of%20alpha-MSH%20release%20by%
20GABA%20via%20a%20Cl-dependent%20Ca2+%20increase%20in%20frog%20melanotropes.pdf 
https://ajpregu.physiology.org/cgi/content/full/290/3/R577 
https://www.jneurosci.org/cgi/content/full/23/32/10351 
https://content.karger.com/ProdukteDB/produkte.asp?Doi=126582 
https://jeb.biologists.org/cgi/content/abstract/203/11/1711 
https://www.annalsnyas.org/cgi/content/abstract/994/1/90 
https://jpet.aspetjournals.org/cgi/content/abstract/271/2/1000 
https://www.ophsource.org/periodicals/ophtha/medline/record/MDLN.7108414
https://www.ophsource.org/periodicals/ophtha/medline/record/MDLN.17003261
https://www.ophsource.org/periodicals/ophtha/medline/record/MDLN.466509
https://www.ncbi.nlm.nih.gov/pubmed/1003058?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.
Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=3&log$=relatedarticles&logdbfrom=pubmed 
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https://joe.endocrinology-journals.org/cgi/content/abstract/90/1/53
https://www.ncbi.nlm.nih.gov/pubmed/7291039
https://grande.nal.usda.gov/ibids/index.php?mode2=detail&origin=ibids_references&therow=237945
https://ajpendo.physiology.org/cgi/content/full/284/6/E1181
https://edrv.endojournals.org/cgi/content/full/27/7/736 https://www.jneurosci.org/cgi/content/abstract/12/3/864
https://www.patentstorm.us/patents/6051555/fulltext.html

10. GABAergic neurons in the peri-LC dendritic zone may provide interneuronal integration for hypothalamic locus ceruleus (LC) noradrenergic neurons, where GABA controls the dopamine-norepinpehrine conversion and adrenergic/sympathetic nervous function.    https://www.jneurosci.org/cgi/content/full/24/9/2313 
https://www.jneurosci.org/cgi/content/abstract/28/22/5806 

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Stress hormones norepinephrine and epinephrine induced apoptosis in blood vessels.
Norepinephrine and epinephrine induce apoptosis of endothelial cells (Ref: Fu YC, Yin SC, Chi CS, Hwang B, Hsu SL, Norepinephrine induces apoptosis in neonatal rat endothelial cells via a ROS-dependent JNK activation pathway. Apoptosis, 2006 Nov;11(11):2053-63;  Yun-Ching Fu, Ching-Shiang Chi, Sui-Chu Yin, Betau Hwang, Yung-Tsung Chiu and Shih-Lan Hsu, Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of β-adrenergic and caspase-2 pathways, Cardiovascular Research 2004 61(1):143-151 - https://cardiovascres.oxfordjournals.org/cgi/content/full/61/1/143; Romeo F., Li D., Shi M., Mehta J.L. Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc. Res. (2000) 45:788–794, https://cardiovascres.oxfordjournals.org/cgi/reprint/45/3/788?ijkey=
bca9f5122205d5f9dd39125a4ede820f97d2e833; Stefanec T. Endothelial apoptosis: could it have a role in the pathogenesis and treatment of disease? Chest (2000) 117:841–854, https://www.chestjournal.org/content/117/3/841.full.pdf+html , Communal C., Singh K., Pimentel D.R., Colucci W.S. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway. Circulation (1998) 98:1329–1334, https://circ.ahajournals.org/cgi/reprint/98/13/1329?ijkey=f6a585d88fef2136ced80d0d9be63425f1870dd1 ).  Thus, chronic elevation of norepinephrine and epinephrine by excessive sex can result in thinning blood vessels and ultimate breakage for bleeding in the brain, prostate, urethra, colon and rectum too. Our empirical data shows the excessive stress hormones elicit the prostate, stomach, colon and rectum bleeding. 

Generally, sex-induced excessive stress hormones, inflammatory hormone Prostaglandin E2,  and over-excitation of histamine H1 receptors cause the stomach problems too. It is one of the sympathetic nervous Fight and Flight responses.

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Anxiety, Neuroimmune Reaction,  and Premature Ejaculation:  Anxiety indicates the serotonin and GABA nervous modulation/control disorders on the autonomic nervous system, leading to the norandrenergic/sympathetic nervous function overpowering the parasympathetic nervous function. This leads to severe premature ejaculation, termed as performance anxiety.
The serotonin and GABA nervous function modulate the norandrenergic/sympathetic nervous function in two ways: the autonomic nervous system (ANS) via direct the norepinephrine (NE) neurons of the hypothalamic locus coeruleus (LC), and the neuroendocrine humoral outflow via the hypothalamus (paraventricular nucleus (PVN))-pituitary-adrenal axis.
The GABAerginic nerves control on the norandrenergic (norpeinephrine) firing in the LC while the sertoninergic nerves reduce the noradrenergic/sympathetic nervous function  by affecting the reflex mechanism via the vagus nerves. The serotoninergic and GABA nerves can also modulate and reduce the somatic and sympathetic nervous sensing and response via the beta-endorphin release.  That is, the GABA, serotonin and endorphin nervous control  can also reduce the seminal vesicles, prostate, bulbourethral and penile nervous sensitivity.
Sexual stimulation, arousal or orgasm ignites the dopamine-norepinephrine conversion in the hypothalamus and adrenal medulla, and, then, activates the norepinephrine (NE) neurons of the locus coeruleus (LC); the neural signals are relayed to the preoptic area of the hypothalamus via the ventral norepinephrine noradrenergic bundle, where noepinephrine is released; then, norepinephrine stimulates the synthesis of prostaglandin E2 in local neurons and/or astrocytes, by activating  a group of proinflammatorycytokines such as IL-1, IL-1ß, IL-6, TNF-, IFN-, and MIP-1in the the immune system. These cytokines, acting as the endogenous pyrogen of desire fires. Prostaglandin E2 sensitizes the sympathetic nerves in the adrenal glands, prostate, seminal vesicles, testicles and penis for norepinephrine release in the nervous endings in preparing for sexual activity. The release of norepinephrine in the local tissues, in turn, triggers the neuroimmunotransmitters cytokins, proinflammatory prostaglandin E2 or antiinflammatory prostaglandin E1 release.  Both prostaglandins initiate erection, followed by the parasympathetic nervous erectile mechanism via the Nitric Oxide and cGMP action, and the binding of norepinephrine in the sympathetic nervous beta-adrenergic receptors.
The inflammatory hormone prostaglandin E2 can sensitize the sympathetic and somatic nerves in the seminal vesicles, prostate, bulbourethral glands and penis and inflame the orgasm to induce precum leakage, followed by ejaculation in few seconds or minutes, depending on the concentration of prostaglandin E1 and endorpin in the precum. 

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Orgasm induced neuroimmune disorders, allergy and asthma
Our reader has reported overshooting of norepinephrine (8.6 nmol/L while the normal is supposed to be less than 4 nmol/L at that time, about 2 hours after ejaculating), IgM (250%), IgE (200%) and C3 (125%) results in brain fog, fatigue, tiredness, muscle and joint stiffness and pain, Heart palpitations (rapid heartbeat), and digestive panic attack
Orgasm induces immune challenge in 2 ways: direct and indirect. The direct one is to respond to the foreign substances bringing to the contact organs including the mouth and sex organs. The indirect one is a neuro-immune response to the orgasm induced norepinephrine release from the hypothalamus and adrenal glands, leading to the elevation of Immunoglobulin (antibodies ). Chronic over-masturbation, over-ejaculation or excessive orgasm generally exhausts dopamine, cholinergic/vagal(acetylcholine), serotonin and GABA nervous control with excessive hypothalamic and adrenal dopamine-norepinephrine conversion for constant sympathetic nervous fight or/and flight, excessive norepinephrine-induced informatory hormone prostaglandin E2 production over your body cells from the head down to the  toes, excessive norepinephrine-induced Immunoglobulin (antibodies such as IgA, IgD, IgE, IgG and IgM) elevation for neuroimmune weakness and disorders, constant elevation of the pituitary prolactin release for autoimmune disorders, and constant constriction and inflammation of your arterial and heart smooth muscles. The problem is: Chronic elevation of the stress hormone norepinephrine and its induced immune suppression will collapse the immune system. There are several symptoms associated with excessive norepinephrine-induced Immunoglobulin elevation and excessive immune-suppression prostaglandin E2 for neuroimmune weakness and disorders.
For sexual induced asthma, sneezing, allergy and sinus, we will have to deal with the excessive norepinephrine induced IgE which triggers excessive release of both histamine and prostaglandin E2.
The antibody IgE, which is found in the lungs, skin, and mucous membranes, is responsible for activation of mast cells to release histamine,  and  for triggering cytokines like interleukin-4 (IL-4) and interleukin-13 (IL-13) and other inflammatory mediators to release inflammatory hormone and immune-suppressor prostaglandin E2.  Thus, overshooting of IgE causes allergy, sneezing and hypersensitivity.  Elevation of the stress neurohomrone norepinephrine will generally trigger the elevation of IgE for allergy, sneezing and hypersensitivity,  and activates enzyme Cyclooxygenase-2 (also known as COX-2) to oxidize arachidonic acid into prostaglandin E2.  Excessive psychological or physical stress, excessive sex, over-exposure to sunlight or intensive heat, air pollution, or pollen can overshoot IgE for allergy, sinus, headaches and other inflammatory diseases.
IgM is found in blood and lymp fluid in response to an infection. It promotes other immune system cells to destroy intruders. However,  Excessive elevation of IgM indicates ectodermal dysplasia and immunodeficiency, or humoral immune defect. 
IgG is found in the body fluid, very important in fighting against bacterial and viral infections. Norepinephrine is not supposed to increase IgG antibodies.
IgA is found in the areas of the body, that exposed to foreign substances. Those areas include the nose, breathing passages, digestive tract, ears, eyes, and vagina. IgA antibodies protect the body surfaces  against outside foreign substances. Sexual intimacy may elevate IgA  in response to the secretion from the mouth, vagina, uterus and  cervix and other sexual aid substances for men, and to the secretion of mouth, the ejaculation fluid and sexual aid substances for women. It is supposed to be an immune challenge.
Chronic over-stimulation of the immune system with excessive stress neurohormone norepinephrine and its induced immune suppressor prostaglandin E2 will breakdown the immune adaptive ability  and collapse the the adaptive immune system, leading to immune disorders. Thus, if your norepinephrine and prostaglandin E2 are not overshooting, immune stimulation with norepinephrine will improve the adaptive immune system to combat pathogens, the alternative term "infectious agents" or the common name "germs."
The other immune complements of the innate immune system,  known as the complement system which is not adaptable and won't change overtime in an individual's lifetime, can be recruited and brought into action by the adaptive immune system. The complement system is a biochemical cascade that clears pathogens by attacking the surface of foreign cells. It contains over 20 different proteins, circulating in the blood and bathing the tissues in an inactive form.  In response to the recognition of  foreign cells, the proteins become sequentially activated, working in a cascade  in which the binding of one protein will promote the binding of the next protein in the cascade. It is the major humoral component of the innate immune response.
The complement cascade is a double-edged sword.  While protecting against the invasion of foreign cells, the complement system has the potential to be extremely damaging to host tissues via its induced inflammation and phagocytosis. A long-term stimulation of the complement system may lead to many diseases associated with an immune component, such as Barraquer-Simons Syndrome, asthma, lupus erythematosus, glomerulonephritis, vasculitis (inflammatory destruction of blood vessels including both arteries and veins)), kidney basement membrane diseases, nephritis (kidney inflammation), hemolysis (rupture of red blood cells), arthritis, autoimmune heart disease, multiple sclerosis, inflammatory bowel disease,  ischemia-reperfusion injuries, and autoimmune disorders,   and to the diseases of the central nervous system such as Alzheimer's disease, Parkinson's diseases,  parkinsonism,  and other neurodegenerative conditions. 

Ref: 
Arachidonic Acid Oxygenation by COX-1 and COX-2 MECHANISMS OF CATALYSIS AND INHIBITION
https://www.jbc.org/content/274/33/22903.full.pdf+html
Complement determinations in human disease
https://www.questdiagnostics.com/hcp/intguide/Immuno/Complement%20on%20IG_Glovsky%20et%20al.pdf 
Neural Adrenergic/Cyclic AMP Regulation of the Immunoglobulin E Receptor α-Subunit Expression in the Mammalian Pinealocyte A NEUROENDOCRINE/IMMUNE RESPONSE LINK?*
https://www.jbc.org/content/282/45/32758.full.pdf+html 

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Orgasm Brain Sex Pain?!! - Oops! Click the links in the left-handed side if you need our case collection since 1997.  Or read some interested cases below:

What is POIS ( Post Orgasmic Illness Syndrome)? Traditional Chinese Medicine (TCM) terms POIS as Qi (Chi)-Blood Stagnation or Blockage, as parts of Sexual Exhaustion Symptoms
==> https://action.love/cases/case16665.htm
On Taoist's ejaculation frequency vs testosterone level and sperm concentration.; 5000-years Sexual exhaustion symptoms were also mentioned by the Seventh-day Adventist church; what is a consistence of old culture wisdoms!
==> https://action.love/cases/case15675.htm
causes and solutions for sexual exhaustion symptoms - body pains, eye floaters, blurry vision, ear buzzing, headaches, chronic non-bacterial prostatitis and poor semen quality and quantity for no sexual orgasm. Why his doctors could not found his UFO symptoms induced by sexual exhaustion!? And Antibiotics won't work but can cause excessive histamine release in certain cells for allergic responses
==> https://action.love/cases/case16082.htm
Why sexual arousal gives him tiredness, and sexual orgasm worsens his tiredness?
https://action.love/cases/case15955.htm
Excessive dopamine-norepinephrine/epinephrine conversion, resulting from parasympathetic/vagal, GABA and serotonin nervous control disorder, induces organ inflammation, brain fog, depression, autoimmune disorder, chronic infection,  inflammatory pain, digestive disorder and panic responses, low libido, premature ejaculation, adrenal fatigue and lyme disease.
==> https://action.love/cases/case15858.htm
On Sexual Energy Exchange during intercourse for the Tao of Love -
He said 'I will continue to use your products for time to time and hang on to your words of wisdom.' on sexual energy exchange during intercourse for more sexual orgasm
==> https://action.love/cases/case15578.htm
why ejaculation or sexual orgasm induced awful depression, anxiety, body pains (dull throbbing gallbladder and liver pain) for a few day - Solution
==> https://action.love/cases/case15444.htm
Pot smoking and alcohol result in memory loss, eye floaters, upper abdominal/stomach pains (went to ER twice for MRI, scans, colonoscopy..), vaginal dryness, uterine cramp and pain, post-sex low abdominal (uterine) pain, allergies. sinus, puffy eyes, headaches, forehead tenderness and no more sexual orgasm
==> https://action.love/cases/case15747.htm
What cause the post-ejaculation and post-orgasm pains, cramps, tightness, joint rigidity and muscle weakness for no more sexual orgasm
==> https://action.love/cases/case15079.htm 
Sexual Hangover - Sex or orgasm induced headache, poor mentality, mood swings, dizziness and vertigo - solution for the severe side effects of sexual orgasm
==> https://action.love/cases/case15010.htm
The similarity of between the penile jelq-induced damage and heart failure as a result of increased collagen synthesis for no more sexual orgasm - A special Penile Enlargement advice
https://action.love/cases/case14906.htm
He said ' I am so incredibly grateful for everything you have done for me so far! My erection is back for good now, and what your miracle products did for my health remains truly without precedence. ViaPal-HgH-J helped me to rejuvenate my penile erectile nerves and revive my dead penis after a very severe penile injury, after I ruptured both of my spongy tissues with one of the jelqing/stretching exercises I had found on the internet.'  Re-grow Corpora Cavernosa and penile nerves, heal penile varicose veins, improve penile curvature, solve penile pains, stop precum, and restore libido and sexual orgasm.
==> https://action.love/cases/case14677.htm
2-week Finasteride (5-alpha reductase inhibitor for Hair ReGrowth and shrinking the enlarged prostate ) disabled his liver 5-alpha reducatse release in blocking the testosterone-DHT conversion for a high testosterone level, but administration of aromatase inhibitor supplements, in conjunction with the side effect of Finasteride, further kept his testosterone level too high, high enough to stimulate the excessive liver SHBG protein release in binding testosterone in the bloodstream for penile shrinkage, no more libido and sexual orgasm
==> https://action.love/cases/case14664.htm
Why drug abuse and antidepression drugs result in excessive prostaglandin E-2 and epinephrine release to induce psychological disorders ( mood swing, anger, and aggression), extremely headaches, shooting pains low stomach swelling, body pains, body heat, light headedness confusion, uncontrollable over-masturbation (persistent sexual arousal), particularly during ovulation, for no more sexual orgasm
==>https://action.love/cases/case14644.htm
Chronically over-masturbating for 2.5 years  resulted in low back pain, testicular pains, groins pains, urethral/penile pains, erectile dysfunction, painful erection, chronic constipation and elevation of the liver enzymes LST and AST (liver damaged index enzymes) for no more sexual orgasm, but pains.
==> https://action.love/cases/case14451.htm
Why a hard core body builder or athletic person experiences penile and testicular shrinkage even if he is taking a lot of Nitric Oxide enhancements; on the role of the sympathetic nervous beta receptors in the penile erection, testicular function and sexual orgasm (the same conditions apply to women's clitoral/G-spot erectile dysfunction, vaginal looseness, and ovarian functional disorder too)
==> https://action.love/cases/case14402.htm
His and her post-orgasm sexual exhaustion symptoms - sympathetic nervous panic and inflammatory responses, low back pains, low abdomen pains/cramps, perineum inflammatory pains, and so on, for no sexual orgasm - solution
https://action.love/cases/case13819.htm
Why ejaculation/orgasm causes his mood swing, anger, aggression, anxiety, stress, fatigue, tiredness.... for no more sexual orgasm -  On the brain and body chemistry change in response to ejaculation or orgasm.
==> https://action.love/cases/case13755.htm
He said ' I want to thank you because your products worked as you say they will and the value I got from them went beyond what I expected.' with ViaPal-hGH-J, DeToxiA and PinealTonin in detoxification of anti-psychotic and bipolar medication drugs for restoration of normal erection and sexual orgasm.
https://action.love/cases/case13900.htm
She said ' a couple months ago I wrote to you about my problem with vestibulitis. your prescribed that i take vial pal hgh j along with borage oil, fish oil, and 5-htp. ... my doctor, who is one of the few vulvodynia and vestibulitis specialists in the country, is amazed by my rapid progress.' for solving vestibulitis, quitting pot smoking and restoring sexual orgasm.
==> https://action.love/cases/case13584.htm
Solution for Persistent Sexual Arousal Syndrome and interstitial cystitis induced by COX-2 over-expression and inflammatory hormone prostaglandin E-2 in the pelvic cavity tissue and for control of unwanted, spontaneous sexual orgasm
https://action.love/cases/case13532.htm
Non-orgasmic semen retention is as bad as over-ejaculation; both are for no more sexual orgasm ,but for sympathetic nervous pains and burning. What is different between both cases in term of the dopamine-norepinephrine-epinephrine conversion?
==> https://action.love/cases/case13176.htm
He said 'I want to thank you for your products. I cannot begin to tell you how great it was for us to be able to have her squirt, and boy did she. I had no idea of the quantity of fluid that would come out or how forceful the ejaculation would be, I know for a fact that the movies that I have seen are indeed real!!!' with Heat Tea and L-Arginine! A realistic experiment for a healthy female ejaculation pumped out by an extremely powerful sexual orgasm!
https://action.love/cases/case13138.htm
Why his doctors and drugs can not solve his non-organic prostate and testicle pains as a result of sexual exhaustion and prostate abrasion for no more sexual orgasm
https://action.love/cases/case13121.htm
He said 'The chikong breathing worked! I thought your site was just after my money, but when I tried your advice my control over ejaculation was exactly like you said. The ballooning trick also worked and I was able to control (for the first time in my life) as long as I wanted' for  more sexual orgasm
https://action.love/cases/case13080.htm
He said 'Your medium dosage of (MoodMax, 5HTP + Dopa Fibra, Dopa Fibra, MoodMax) has been great.'  for more sexual orgasm. How to shut down and boost your oxytocinergic nervous action for control of libido, erection and  sexual orgasm.
https://action.love/cases/case13040.htm
Chronic over-masturbating from age 14-31 results in all of the sexual exhaustion symptoms, some fatigue, graying of hair, hair thinning, eye floaters, sinus, ear aches, and sleeping disorder for no more sexual orgasm. On the arylalklamine N-acetyltransferase gene expression disorder in the pineal gland and retina for circadian rhythm and visual nervous disorders. Why can a good sex improve your health?
https://action.love/cases/case12909.htm
She said ' i am glad to notify you that it's unbeleavable how i have managed to get almost all my problems eliminated.as of now',  no more depression, hypertension, painful periods due to fibroids, migraine headache, vaginal muscle weakness, urinary sensation reaction, nausea, chronic sinuses, painful nipples, and low libido, but for sexual orgasm; on the pineal gland gene expression disorder.
==> https://action.love/cases/case12813.htm
Over-ejaculating several times in 20-50 minutes have abraded his prostate and elevated a high PSA release for many days - for self destruction and no more sexual orgasm!
https://action.love/cases/case12785.htm
ViaPal-hGH-M and DeToxiA have helped her resolve her chronic bladder disorder/ incontinence, vulva pain (Vulvodynia & vestibulitis ) & throat infection (tonsils), restore her menstrual cycle, and smooth out her PMS Pains/Cramps, for restoration of sexual orgasm
==> https://action.love/cases/case12703.htm
Chronic over-masturbation/over-ejaculation or excessive orgasm alternates the Dopamine D1 and D2 gene expression for sympathetic nervous fires - no sexual orgasm - the brainwash solution..
https://action.love/cases/case12612.htm
The cellular biochemistry of premature ejaculation for no more sexual orgasm.
==> https://action.love/cases/case12610.htm
How to treat pot smokers' common problems for restoration of sexual orgasm
==>https://action.love/cases/case12583.htm
Why his penile stretching enlargement exercise for 2 days results in youth (teenager's) impotence, glans shrinkage, premature ejaculation and low libido for no sexual orgasm
==> https://action.love/cases/case12560.htm
A senior medical student said ' I have already been taking ViaPal-M for around 2 1/2 weeks and I must say that the results have been significant improving my symptoms of anxiety, poor memorization, acne, depression, etc. ' for sexual orgasm, and questioned on medication drugs for psychological and physiological disorders.
https://action.love/cases/case12529.htm
Why this 20-year old man experiences orgasmic dysfunction and  withdrawal  for no sexual orgasm. On the role of prolactin and oxytocin in the sexual and orgasmic functions and in the switching of sympathetic nervous beta and alpha receptors for orgasmic contraction for men and women.
==> https://action.love/cases/case12488.htm
Chronically masturbating twice a day lets her feel sexually unfulfilled, crave for more sex, and experience cramps in the low abdomen and back for sexual exhaustion symptoms, but no sexual orgasm. On the physiology and psychology of orgasm
==> https://action.love/cases/case12487.htm
Dr. Lin's advices to a porn actor: Avoid multiple ejaculation in one day; Knock out all your partners with one and only one ejaculation for the most violent sexual orgasm by rhythmically stimulating the clitoris and blending the G-spot and Epicenter/cervix at the same time; Drink your own first morning pee - the Natural Spectrum Hormone Therapy.
==> https://action.love/cases/case12460.htm
Chronic Over-masturbation causes a chronic elevation of prolactin for seminal / sperm production disorder, low libido, orgasmic disorder for infertility and no more sexual orgasm!  Why?
https://action.love/cases/case12388.htm
Over-masturbation/over-ejaculation and drugs abuse killed his brain and nervous functions for chronic headaches, blurred vision, ear ringing and no more sexual orgasm. Here is Dr. Lin's Brainwash Engineering treatment.
https://action.love/cases/case12366.htm
Over-masturbation has alternated and exhausted this 19-years old boy's brain/nervous functions for pains in the testicles/penile/groins/low abdomen/low back/everywhere, eye floaters and  suicidal thought for no more sexual orgasm, beyond ability of his psychologist and urologist and SSRIs antidepression drugs. The brain/nervous function destructed by over-masturbation or over-ejaculation can not be healed naturally! Here is Dr.Lin's cheap 'Brainwash' solution.
https://action.love/cases/case12364.htm
After he spent all his money, why all his doctorS and all the prescription drugS can have never solved his non-bacterial prostatitis and prostate swelling with frequent urination, perineum heat/pains, and hair loss, leading to no more sexual orgasm - Here is Dr. Lin's cheap solution - The Natural Prostaglandin E-1 therapy.
==> https://action.love/cases/case12346.htm
He said ' I have purchased your ViaPal-hGH-J pack and have been very happy with the results with an improvement after only 2 weeks.' how to balloon your penis and her clitoris/G-spot/vaginal/urethral erectile tissues for more sexual orgasm!
==> https://action.love/cases/case12339.htm
Why his optometrist can not see his eye floaters resulting from over-masturbation/over-ejaculation or excessive sexual orgasm
==> https://action.love/cases/case12334.htm
He said ' I have sexual functioning again.' with ViaPal-hGH-P; Re-Grow his circumcised foreskin, enlarge his penis, restore his orgasm and penis sensitivity after jelqing damage,  and shrink his enlarged prostate back to normal for peeing, and solve his urinary tract infection (UTI) for  more erection and sexual orgasm.
==> https://action.love/cases/case12265.htm
Finally, a 21-year old  heavy-duty pot-smoking, post-hernia-operation over-masturbator said ' my urinary incontinence is absolutely GONE AWAY...  Thanks for your great product Dr.Lin !!'  Restoring his sexual orgasm in only 1 month!
https://action.love/cases/case12201.htm
[Warning: This article may be very offensive to you, but you can learn about the relationship between the penile/vaginal temperature and orgasmic response, and the relationship among the urogenital blood circulation, urinary continence, androgen hormones and prostaglandin E-1. For a better sex, keep your penis/clitoris/vagina hot, but your brain cool; that is, pump your blood down to your sex organs, but not to your brain during lovemaking!  Their sexual adventures in helping us cross-verify our long-term hypotheses should be highly appreciated! OK, Here we go for it:
After her husband failed to maintain his erection for her, she is interested in dog sex for sexual orgasm. Can she have a dog tie? Dr. Lin's saddest advice! Updated (3/17/2004): She had experienced powerful multiple orgasms with the high-temperature dog penis and semen (3 degrees F higher than the human's). The result of the Dog Sex experiments can lead to a new powerful therapeutic concept for urinary incontinence! Why?
==> https://action.love/cases/case12137.htm]
Dr. Lin's penile growth theory and permanently penile enlargement for you to go all the way to heaven and to have more sexual orgasm after you die.
https://action.love/cases/case12121.htm
How urethral female ejaculation occurs and produces pelvic/bladder/urethral/vagina/uterus spasms and legs shaking (a temporary Parkison's phenomenon by sexual stimulation) , but no sexual orgasm; on the formation of  the sensory-sympathetic L1/L2 nervous reflex arc.
==>https://action.love/cases/case12082.htm
He said ' i have been purchasing your products for about 4 months now for my wife. and they have helped a great deal!' for her Interstitial Cystitis (IC), fibromyalgia, migraine headaches, sleeping disorder, vaginismus (penetration/intercourse pains) and restoration of sexual orgasm - This serious case has been abandoned by the medical societies.
==> https://action.love/cases/case12046.htm
Ear ringing (Tinitus) - the ear stresses out for no sexual orgasm
==> https://action.love/cases/case12026.htm
He said 'we all should recommend you for a noble prize in your field of study.' after experiencing the powerful Dr. Lin's Natural  Prostaglandin E-1 therapy for prolonging his erection and sexual orgasm, increasing his semen production, darkening his hair, dropping his bad cholesterol level and blood pressure (with a high dose of Yohimbe in DopaFibra!?), eliminating his body pains ...
==> https://action.love/cases/case11983.htm
Solution for the post-ejaculation or post-orgasmic brain/nervous disorder, trauma and fatigue - for sexual orgasm
==> https://action.love/cases/case11980.htm
She said ' I ordered your products Moodmax, Viagrowth-IV and 5htp for vaginal looseness right before Christmas.... I can say Your products really work. Thank! You have a customer' for Vaginal Tightness and more sexual orgasm! Again, the Dr. Lin's Natural Prostaglandin E-1 Therapy
==>https://action.love/cases/case11964.htm
Dr. Lin's Prostatitis solutions - the restoration of sexual orgasm with Natural Prostaglandin E-1 therapy.
==> https://action.love/cases/case11924.htm
An endocrinology doctor's experience with over-masturbation or over-ejaculation, resulting in prostatitis, urethritis, erectile dysfunction, low libido, and pains in penis, low back, perineum and anus for no more sexual orgasm -Solution
==> https://action.love/cases/case11918.htm
He said ' dear dr lin WOW it worked!!!! i took borage oil 1 capsule a day,3 capsules fish oil and 6 capsules of flaxseed per day.....RESULT- longer sexual intercourse didnt cum as quick and a much harder penis that increased in length by 1 inch and a fatter girth my girl loved my 8inch cannon. i notice also after doing your breathing method i can shoot my big cannon for another round i also take your moodmax and viagrowth4 great stuff' for more sexual orgasm and having Merrier X'mas and happier holidays!
==> https://action.love/cases/case11904.htm
He said ' Thank you for a wonderful set of products and information! I have enjoyed them and I believe they have assisted me and my wife to enjoy sex more and conceive a child on our first try!' for a life-term sexual orgasm.
==>https://action.love/cases/case11818.htm
He said ' Hello, I have been taking the fish oils and the borage oils now for 4 weeks. I am also very pleased with your products and my hair as well as my wife's hair is turning dark again. My wife has been almost white since her late 30's This is nothing short of a miracle. Thank-you.'  for more sexual orgasm! On Dr. Lin's Natural Prostaglandin E-1 therapeutic formula ==>https://action.love/cases/case11805.htm
She has proved what Dr. Lin said - tubaligation results in the state of peri-menopause and menopause transition for PMS and no more sexual orgasm.
==> https://action.love/cases/case11800.htm
He said 'Love the products....... my eyesight is so much improved...... I wonder why this is? ' for more sexual orgasm - the electric engineering solution for eyesight and eye floaters.
https://action.love/cases/case11735.htm  
He said ' I have been practicing your ballooning method since 1998. I went from 5inches to 7 inches. Then you told me I have probably reached my full potential, that my foreskin was limiting me, which I believe is correct.' on the penile and hair re-growth for more sexual orgasm. On the calculation of the nervous erectile power change based upon the penile shrinkage rate.
https://action.love/cases/case11591.htm
How drugs take over your brain and nervous system and how to detoxify your brain and nervous fiber/synapse for restoration of sexual orgasm.
==> https://action.love/cases/case11500.htm
When Prostatitis can not be solved by over-ejaculation and antibiotics, you are asking for more troubles - for no more erection (impotency and sexual exhaustion) and sexual orgasm -Solution
==> https://action.love/cases/case11430.htm
On seminal retention and prostate-cancer protection, and of course, on Over-masturbation and sexual orgasm
==> https://action.love/cases/case11407.htm
He said 'when i take your detox pill i feel really relaxed and think clearly do you know why that is.' a full detoxification of the liver and nervous system for better health and sexual orgasm
==> https://action.love/cases/case11347.htm
He said ' By the way, about your 5-htp. ANOTHER GREAT PRODUCT. ... last week when I got the attack, I opened an additional capsule and poured the powder beneath my tongue (sublingually). It COMPLETELY stopped the migraine progressively over a one hour period. WITH NO SIDE EFFECTS!'; more sexual orgasm without headaches and migraine or panic attack.
==> https://action.love/cases/case11323.htm
On the role of DHT in the penile Growth, Repair (Re-Growth) and structure for more sexual orgasm.
==> https://action.love/cases/case11311.htm
Evidences show destruction of pot (marijuana) smoking, resulting in low libido, erectile dysfunction, premature ejaculation and low seminal production for no more sexual orgasm
==> https://action.love/cases/case11303.htm
He said 'first of all, may i thank you for your miracle products, they have totally transformed my life.' ViaPal-hGH-P and 5-HTP have rejuvenated his damaged penis and resumed his seminal production for ejaculation and sexual orgasm through normal vaginal intercourse.
==> https://action.love/cases/case11269.htm
He said ' Love+your products= AMAZING! What's going on inside my brain, chemically, since I don't feel like eating? I'm not tired either.'; less foods and more sexual orgasm.
==> https://action.love/cases/case11191.htm
He said 'I am nearly at the end of my course of ViaPal-HGH-P (3-010) and I have experienced excellent results. I no longer suffer from extreme fatigue, blurred vision, buzzing ears or nasal congestion after ejaculation. Thank you very much for your help!' on retaining the brain concentration after ejaculating or having sexual orgasm
==> https://action.love/cases/case11147.htm
He said 'I feel like a New Man I have No Erection Problems. My erection are very firm and long lasting. I had to take a weaker dosage because I was waking up and walking around with an erection for long periods..' for more sexual orgasm
==> https://action.love/cases/case11119.htm
What are the differences between the Penile Ballooning and Penile Exercises/Jelqing/Milking for penile enlargement?
==> https://action.love/cases/case11114.htm
On the effect of the vaginal/cervical secretion on penile erection/ballooning and premature ejaculation. Why one tight vagina makes him erect harder and last longer for sexual orgasm , but the other tight one promotes his premature ejaculation?
==> https://action.love/cases/case11032.htm
He said 'I could say that you made me a man again.' and gets recovered from extremely sexual exhaustion due to pre-teen over-masturbation; on buzzing ears; Why don’t write a book for parents about how to teach their sons the sexual energy control and development?
==> https://action.love/cases/case10924.htm
A MD (a vasectomy victim too!) said 'I had 6 orgasms within a 36 hour period,.... Your products amazingly both help achieve strong erections, reduce the refractory period between intercourses, and maintain sensitivity while enhancing stamina and endurance of erections. Quite unbelievable. ' Oops! excessive sexual orgasm!.
==> https://action.love/cases/case10881.htm
She said 'Your products amazed me. After not being very orgasmic at all for 35 years, I began to experience wonderful orgasms often and my libido is sky high. I love it.'  What is the origin of our products?
==> https://action.love/cases/case10632.htm
Prostate's seminal production disorder for no more ejaculation and sexual orgasm; Under forcing with a heavy urethral stimulation, the male ejaculation is the same as the female ejaculation fluid.
==> https://action.love/cases/case10876.htm
Non-bacterial (non-organic) testicular and penile pains due to ejaculation - why and solution.
==> https://action.love/cases/case10853.htm
Neurophysiological approach for overcoming the masturbation addiction
==> https://action.love/cases/case10797.htm
Why over-masturbation or excessive clitoral orgasm results in chronic clitoral pains for no more sexual orgasm
==> https://action.love/cases/case10793.htm
Viapal-hGH-M has revived a 5-year marijuana smoker's erection for the first times in 5 years! He needs DopaFibra too for a faster healing.
==> https://action.love/cases/case10740.htm
Don't let Ecstacy (MDMA) fry your brain and nerves for a short-term fun, but not for a long-term sexual orgasm. Updated - He messed up his brain in 4 months on New Year Eve of 2003!
==>https://action.love/cases/case10350.htm
Over-masturbation causes 14-year old boy's endless (continuous) seminal leakage for no sexual orgasm; on destruction of the prostate's ejaculation nervous controller and modulator; The endless ejaculation can cause death during lovemaking, but How to stop it!
==> https://action.love/cases/case10592.htm
When 'chronic non-bacterial prostatitis' (now called 'chronic pelvic pain syndrome') is the Prostate's Seminal Blasting Syndrome,' your prostate produces no much semen, resulting in retarded ejaculation, no sexual orgasm and vibrator-induced penile damage..
==> https://action.love/cases/case10580.htm
Mechanism of the Penile Ballooning for a better sexual orgasm - on the the 2-stage penile erection theory for Penile Enlargement.
https://action.love/cases/case10565.htm
His dog makes his girl friend achieve a Level-7 orgasm,but he gives her intercourse pain for no sexual orgasm. Now, Learn the doggy-style lovemaking.
https://action.love/cases/case10535.htm
The final chapter of Penile Enlargement for no sexual orgasm
https://action.love/cases/case10492.htm
Dying of Young girl's clitoris and G-spot - losing her sexual orgasm.
==> https://action.love/cases/case10292.htm
Excessive sexual orgasm, excessive histamine release, rear-brain and neck pain, orgasmic nasal congestion, allergic responses, and dark eye circles.
==> https://action.love/cases/case10263.htm
Cause and Solution of orgasmic convulsions upon ejaculating - the seizure response to sexual orgasm
==> https://action.love/cases/case10241.htm
He said ' You "My Friend" are the King of Love'; ViaPal-hGH-M resolves his Chronic penile pain; On Dr. Lin's Bioelectric Theory of Love Science.
==> https://action.love/cases/case10097.htm
On the Liver P450 Detoxification and the liver protection for health and sexual orgasm
==> https://action.love/cases/case10000.htm
General Solutions for women without experiencing sexual orgasm
==> https://action.love/cases/case9864.htm
But, what are General causes? Here are the General problems:
How to enlarge (loosen)  your vagina, shrink (yes, kill ) your clitoris and G-spot, and produce urinary/bowel incontinence? (click here for destruction of vibrator); How to become an impotent young man? (click here); How to shrink your penis?(click here) or How to break a penis! (click here with women-wild rides or penile enlargement practices); How to destroy (castrate) your sexual functions by masturbation, drugs (including SSRIs and birth control pills/shot - one shot kills it all!), or Vasectomy( - two cuts kill them all;) How to get a pseudo-prostatitis; How to produce eye floaters;  Finally, you want to know how to become a fastest semen-shooting (ejaculation)  man in lovemaking or dry up your seminal ejaculation or production.  
The variation of the brain's neurotransmitters in response to ejaculation and sexual orgasm - on the Penile Ballooning Method for penile enlargement and the destruction by over-masturbation and over-ejaculation .
==> https://action.love/cases/case9875.htm
Destruction produced by Male or Female Over-Masturbation for no sexual orgasm.
==> https://action.love/cases/case9848.htm
The principles of the Penile/G-spot/Clitoral enlargement and Vaginal Narrowing (Reduction, yes!) are the same thing! for more sexual orgasm.
==> https://action.love/cases/case9819.htm
Brain's and nervous functions, Orgasm Headache, and nausea associated with excessive sexual orgasm (Orgasmic Stress); on anorgasm, stress effects and de-stress.
==> https://action.love/cases/case9814.htm
When the holes down there become bigger, they will cause pain, but why? So, How to downsize the holes for men and women. Yes, his and hers!
==> https://action.love/cases/case9767.htm
Causes and solutions for PMS, Intercourse, penetration or orgasm pains/cramps, tilted or prolapsed uterus, and sexual orgasm; Love Positions and vaginal air trapping/pumping/escaping.
==> https://action.love/cases/case9756.htm 
He said ' I want you to KNOW that your 'pills' have done more for me..' beyond sexual orgasm.
==>https://action.love/cases/case9689.htm
Penile Enlargement, DHT, Prostaglandins, Nitric Oxide and cGMP
==> https://action.love/cases/case9663.htm
On Penile Enlargement and  Reader's experience on Dr. Lin's Male Multiple Orgasms without ejaculation.
==> https://action.love/cases/case9647.htm
Mechanism of sexual orgasm, damage of sexual nerves, and lesson from labor orgasm
==> https://action.love/cases/case9589.htm
How do you know she achieve orgasm? on Penile Size and Penile enlargement, female sexual orgasm responses and dysfunction.
https://action.love/cases/case9566.htm
Hair loss, 5-alpha reductase, prostate enlargement, erectile dysfunction, Prostaglandin, Vaginismus, Intercourse pain, Oxytocin and powerful sexual orgasm
==> https://action.love/cases/case9580.htm
Principles and mechanisms of the Natural Penile Enlargement - Ballooning Method for more erection and sexual orgasm
==> https://action.love/cases/case9499.htm
How to become a multiple Sexual-Orgasms couple.
==> https://action.love/cases/case9303.htm
Male multiple orgasms without ejaculation by the Anal Breathing Method - The principle, tricks and conditions.
==>https://action.love/cases/case9422.htm
Do you want to know More Good News for Sexual Orgasm? Click Here; Or the most self-destructive Sexual Practice (click here)?
Interaction between the brain/nervous systems and the love-power generators (uterus, cervix and ovaries); no hysterectomy if avoidable.
==> https://action.love/cases/case9341.htm 
She said 'following your advice my husband has a new penis' and 'I had 30% less flow - relief' from heavy menstruation with your CD-ROM and products. For better sexual orgasm
==> https://action.love/cases/case9275.htm
She said 'I orgasmed 3 times! AND, my husband had his first multiple orgasm.' with Dr.Lin's Sexual ChiKong Intercourse technique
==>https://action.love/cases/case9171.htm
Neurophysiological Explanation of Sexual ChiKong Intercourse for multiple sexual orgasms and ejaculation control
==>https://action.love/cases/case9194.htm
She has enlarged her Clitoris and G-spot with ViaGrowth-IV and Finger Pliers and Penile Screwing massages for more intensive sexual orgasm; but how to continue the practice without him.
==>https://action.love/cases/case9214.htm
Over-masturbation and over-ejaculation result in impotency, premature ejaculation, headache, memory loss, yellowish face, and absentmindedness - the Solution.
==> https://action.love/cases/case9263.htm

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Sex is in the brain
The penis, clitoris and vagina are only the love tools, the power tools which are actuated by the brain/parasympathetic battery - the healing power generator.
To achieve orgasm (as energy pulsing discharge driven by the brain/sympathetic nervous function), even multiple sexual orgasms for men and women, you have to power the brain/nervous/liver/adrenal/cardiovascular/testicular (ovarian) functions in the first place. Why? (click here). The brain function + sexual technologies = multiple sexual orgasms. Caution: Medication and/or street drugs, alcohol, cigarette,  birth control pills or injection may perform chemical castration for your brain - disconnecting  or weakening the parasympathetic nervous communication (the acetylcholine bioelectro-chemical link) between the brain and the love tools, leading to impotency and frigidity. The good news is, we can help you restore and repower your brain function for relinking your love tools with our ViaPal-hGH products.
Sex is in the brain?  Yes,  Please read "Dr. Lin's formula helps a 65-year old tree grow new sprouts and tender leaves for hard erection and sexual orgasm."
==>https://action.love/cases/case9144.htm
<< Detoxify and power your liver,  OR lose your brain/neuro-endocrine functions and shrink your love tools (the male and female penises!)! Keep your major biochemical factory the liver alive! >>
The role of the liver in male and female 'penile erection' and sexual orgasm. And VAGINISMUS !
==> https://action.love/cases/case9098.htm 
What's wrong when the labia minora is larger than trhe labia majora? for sexual orgasm?
==> https://action.love/cases/case9340.htm 
Get ride of SSRIs antidepressants and have Level-7 sexual orgasm back! Here is the How-to
==> https://action.love/cases/case9117.htm
Over-Masturbation/Ejaculation has killed his liver and neuro-endocrine functions for no erection and sexual orgasm!
==> https://action.love/cases/case9096.htm 
Healing of the damaged tissues and nerves done by vibrators or vacuum pumping, for sexual orgasm .
==>https://action.love/cases/case9087.htm
How to Reverse aging for erection and sexual orgasm - the stress-hormone busters and the parasympathetic nervous power generators!
==>https://action.love/cases/case9068.htm
Balance the brain's parasympathetic (acetylcholine), sympathetic (dopamine/norepinephrine/epinephrine), and Serotonin functions for prolonging intercourse and sexual orgasm; also the difference between masturbation (self-intercourse) and lovemaking
==>https://action.love/cases/case9032.htm
He said 'your sex chikong breathing works great' for control of ejaculation
and sexual orgasm, but how to do it right? Why it works? Turn the lungs into the air
compressing chamber and Increase the neurotransmitter CO (Carbon Monoxide) and NO
(Nitric Oxide) levels in the brain! 
==>https://action.love/cases/case9050.htm

Warning: High-level sexual orgasms can destroy pregnancy! (click here more information on this topic)
https://action.love/cases/case8570.htm

Better News: (the best news is that you and your partner experience multiple orgasms again and again to supercharge both bodies in an one or two hour love session! ) Get the most benefit from lovemaking -
He and his girl friend get extraordinary benefits from sexual orgasm with Dr. Lin's formulas - Sexual Orgasm recharges their bodies instantly for health!.
==>https://action.love/cases/case8949.htm
more and more...
Customers with blood-pressure or heart conditions love ViaPal-hGH-X for better sexual orgasm
==>https://action.love/cases/case9015.htm
ViaGrowth-II helps him release tight muscles and Dr. Lin's Sexual ChiKong makes him last for 90 minutes and gives her a lot of sexual orgasm
==>https://action.love/cases/case8944.htm
He gains 2 inches with Dr.Lin's Natural Penile Enlargement Method for more sexual orgasm
==>https://action.love/cases/case8902.htm
ViaPal-hGH-D powers his penis like a rock-hard rod and the 3-Point Love Position gives her eruptive orgasms.
==>https://action.love/cases/case8938.htm  
Dr. Lin's formula solved his adrenal insufficient, chronic fatigue and depression.
==>https://action.love/cases/case8901.htm
ViaGrowth-IV strengthens her vaginal muscle, helps her achieve orgasm and rejuvenates her body (grows the G-spot and Clitoris?).
==>https://action.love/cases/case8889.htm
He sad 'ViaPal-hGH-X is the only supplement working for me.' for heart and blood-pressure patients' Health and Sexual Orgasm
==>https://action.love/cases/case8890.htm
He said our products have made his g/f reach very powerful multiple-cycle sexual orgasm and himself enlarge his penis to more than 7 inches from 5.3 inches; he wants more for her!
==>https://action.love/cases/case9046.htm
He said 'Fibra + Ginseng Power Max numb my penis' for prolonging intercourse and ViaGrowth products for more sexual orgasm !
==>https://action.love/cases/case9041.htm
Experience of Penile Ballooning and enlargement for sexual orgasm !
==>https://action.love/cases/case9035.htm

More interested results in health rejuvenation  ? 
More interested results in Sexual Technology?
More interested results in Technical Support?
More interested results in Sexual ChiKong Intercourse?

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Please Read these articles first!
How to Emulate the Vibrator stimulation with a penis for her multiple sexual orgasm (s)
==>https://action.love/cases/case8848.htm
Dr.Lin's lovemaking methods re-ignite her fire, passion and hope for sexual orgasm
==>https:/https://action.love/cases/case8840.htm
He said 'Your products are certainly helping the healing process. ' - more sexual Orgasm
https://action.love/cases/case8857.htm
Solution for venous leakage for more erection and sexual Orgasm
https://action.love/cases/case8856.htm
He said 'Your ViaGrowth-IV works as advertised.' - more erection and sexual Orgasm
https://action.love/cases/case8855.htm
How to increase Orgasm hormone Oxytocin and reduce orgasm inhibitor Prolactin for more sexual orgasm: Direct Stimulation of the Epicenter causes a Oxytocin burst, but her vagina must be tented up and her clitoris and G-spot must be swollen to 5-6 times in size, to prevent orgasmic pain.
==>https://action.love/cases/case8745.htm
Dr.Lin's theory of orgasmic excitation for breaking the orgasmic barrier to achieve sexual orgasm in every lovemaking.
==>https://action.love/cases/case8601.htm
Dr. Lin helped her successfully develop her sexual orgasm.
==>https://action.love/cases/case8693.htm
Advice to young couples on development of vaginal sexual orgasm
==>https://action.love/cases/case8609.htm
Sexual Chikong Demonstrations help her tune her sexual muscle for multiple, sexual orgasms and female ejaculation.
==>https://action.love/cases/case8649.htm
The Tao of Male Sexual Orgasm
==>https://action.love/cases/case8739.htm
Glad to hear her successful story for health and sexual orgasm
==>https://action.love/cases/case8785.htm

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Update News: 3/9/2000::
We are restoring the files one by one. Please be patient! Dr. Lin has to walk through more than 10,000 web pages one by one to make sure that they are trade-marked drug names free! The appearance of the most famous trade-marked erectile drug name in the web pages forces us to take this action. Now, Dr. Lin is reconstructing the Orgasm Research Center HERE. We have received thousand e-mails in last few days (3/5-3/10) concerning the shut-down of linplaza.com. Your continuous support and encouragement have been highly appreciated.

We have developed the most powerful products for rejuvenation of body function and health, which reverse the natural aging and the side effects of drugs on sexual functions.  Our sexual technologies (lovemaking methods, Sexual ChiKong Intercourse, Natural Penile and G-spot/Clitoral Enlargement)  and dietary supplements have helped love couples regain their love and joy. The detail is in /extra/relate.htm (click here).

One reader said 'your website was the truly genuine and useful one ...Your products are also the only ones I had resolved to use..' 
We are very proud of the integrity of our services and the effectiveness of our products in help loving couples out, so Dr. Lin's orgasm legend has been continued here! Welcome back, Folk!
HERE are few examples of readers and customers' correspondences during the shut-down of linplaza.com:
==>https://action.love/cases/case8886.htm
==>https://action.love/cases/case8885.htm
==>https://action.love/cases/case8884.htm
==>https://action.love/cases/case8883.htm
==>https://action.love/cases/case8882.htm
==>https://action.love/cases/case8881.htm
==>https://action.love/cases/case8880.htm
==>https://action.love/cases/case8879.htm
==>https://action.love/cases/case8878.htm
==>https://action.love/cases/case8877.htm

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Please Read these articles first!
How to Emulate the Vibrator stimulation with a penis for her multiple sexual orgasm (s)
==>https://action.love/cases/case8848.htm
Dr.Lin's lovemaking methods re-ignite her fire, passion and hope for sexual orgasm
==>https:/https://action.love/cases/case8840.htm
He said 'Your products are certainly helping the healing process. ' - more sexual Orgasm
https://action.love/cases/case8857.htm
Solution for venous leakage for more erection and sexual Orgasm
https://action.love/cases/case8856.htm
He said 'Your ViaGrowth-IV works as advertised.' - more erection and sexual Orgasm
https://action.love/cases/case8855.htm
How to increase Orgasm hormone Oxytocin and reduce orgasm inhibitor Prolactin for more sexual orgasm: Direct Stimulation of the Epicenter causes a Oxytocin burst, but her vagina must be tented up and her clitoris and G-spot must be swollen to 5-6 times in size, to prevent orgasmic pain.
==>https://action.love/cases/case8745.htm
Dr.Lin's theory of orgasmic excitation for breaking the orgasmic barrier to achieve sexual orgasm in every lovemaking.
==>https://action.love/cases/case8601.htm
Dr. Lin helped her successfully develop her sexual orgasm.
==>https://action.love/cases/case8693.htm
Advice to young couples on development of vaginal sexual orgasm
==>https://action.love/cases/case8609.htm
Sexual Chikong Demonstrations help her tune her sexual muscle for multiple, sexual orgasms and female ejaculation.
==>https://action.love/cases/case8649.htm
The Tao of Male Sexual Orgasm
==>https://action.love/cases/case8739.htm
Glad to hear her successful story for health and sexual orgasm
==>https://action.love/cases/case8785.htm

---

Warning: High-level sexual orgasms can destroy pregnancy!
https://action.love/cases/case8570.htm

---

Hot Topic:
How to power up the penis, last longer and resonate her sexual orgasm!
https://action.love/cases/case8544.htm
Dr. Lin's formulas reverse the side effects of hair-growth drugs and restore erection for sexual orgasm!
==>https://action.love/cases/case8572.htm
The Screwing Finger Pliers for all ages. Never too old to enjoy more sexual orgasm with Dr.Lin's sexual ChiKong Practice
==>https://action.love/cases/case8573.htm
New tricks help women develop vaginal sexual orgasm
==>https://action.love/cases/case8575.htm
An erectile drug User confirms Dr. Lin's liver and hormonal dynamics for sexual orgasm!
==>https://action.love/cases/case8590.htm

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Feature Topics:
Vasectomy, ejaculation disorder, and sexual orgasm.
Outline of powering up the penis and clitoris/G-spot/Epicenter for prolonged intercourse and multiple sexual orgasm (s)
Dr.Lin's Sexual Chikong let him experience sexual orgasm induced by Tailbone-muscle contraction without semen ejaculation and prostate contraction!
How to Become an Impotent (Pre-aged) Young Man (click here)
Readers' experiences: How to break a penis! (click here)
Tips for her multiple orgasms (click here)
Full solutions for powerful erection, lasting longer and her sexual orgasm! (click her)
He said "Heat Tea triples her G-spot size; what should I do for her sexual orgasm?"
Cornell's Ob/Gyn professor's website is for sexual orgasm too.
Use morning intercourse (without ejaculation for growing the penis) or Screwing Finger Pliers Method to grow her G-spot and Epicenter for sexual orgasm.
He said Dr. Lin's Natural Penile Enlargement (Power-Up or Ballooning) Method works well, for sexual orgasm.
The effects of hormone change on sexual orgasm.
An erectile drug user with high-blood pressure likes the full spectrum-hormone releaser for better sexual orgasm.
How to benefit from Sexual Orgasm.
He experienced an unusual erection and sexual orgasm with ViaGrowth-III which is for the Natural Penile and G-spot Enlargement

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GOOD NEWS:
Dr.Lin's philosophy of formulating full-spectrum hormone releasers for sexual orgasm, without any side effects (why?). The Taoism approach.
==>https://action.love/cases/case8463.htm

Since our establishment of this website in May of 1997, We have successfully served more than 20,000 couples (as of 7/19/1999, with 30-40 e-mails a day). This website contains more than 2000 COPYRIGHTED documents. It is the most complete data base for sexual technologies and problems/solutions. It may take you a few weeks or months to go through it.
We have highly appreciated your contributions - your important questions. Sometimes, you may get a delay or sluggish response from Dr. Lin as a result of e-mail overloading. This always happens during weekends. But, Dr. Lin will never ignore your important E-mail(s) as long as you have submitted your questions with Your Correct E-mail Address. Note: We reserve the right to publish the original correspondences between you and Dr. Lin, but your name will be deleted under our 1000% privacy-protection guarantee.
BREAKING NEWS:
Now, we are enterprising our business to serve you better.
A combination of Our 10-year R & D, the 5000-year Taoists' wisdom, and the modern bioengineering advanced finally concludes our New Products, ViaGrowth-I, II, and -III, helping men and women rejuvenate the natural body functions, the aging body, and the shrinking sex organs. They are available Now!
[TLI News Updated 9/1/1999] - Our success with ViaGrowth products, after 3-month introductory pricing and customers responses during 6/1/1999-8/31/1999, would like to continue benefitting all brothers and sisters around the world with reduced pricing.
Upon request of Mrs. Lin, we add ViaGrowth-III (60 tablets) to the Heat Tea package at no extra charge. We could not build this website to help you out and Dr. Lin could not write his book " Resonant Excitation of Sexual Orgasms," without her wisdom. We have honored her request for benefitting all the sisters around the world. ViaGrowth-III is very effective to resolve post-menopause hot flash, intercourse/post-orgasmic pain/cramp and PMS.
We also add the Fibra or Energia (for Heart/High-blood-pressure patients) to the ViaGrowth products as a package deal for Teenagers/ Young Men (ViaGrowth-I), 30-somethings (ViaGrowth-II), and middle agers (ViaGrowth-III). The most effective packages for middle agers, seniors and Erectile-drug Users are the full-spectrum hormone releasers, ViaPal-hGH-P and ViaPal-hGH-E (for heart and high-blood pressure patients.) We also include ViaGrowth-II into Androbolic for the high-performance, 20-70's men to shorten the Refraction Period or Time to re-arm their love weapon.
Our 10-year studies on pain and cramp in the muscles, ligaments and joints conclude "Blood Congestion" and "Hormone (DHEA/testosterone) Deficiency" in the local tissue are the most common causes. So, we offer our solutions with Pressure or Vacuum-cupping Massage and hormone-boosting supplements such as Heat Tea, PeniSOS, ViaGrowth-I, -II, and -III. They are the solutions for chronic pain or cramp in the back (from the shoulders to the tail bone), legs/toes, groins, thighs, hands/wrists/fingers, and intercourse and post-orgasmic pains or cramps.
ANOTHER BREAKING NEWS (updated 9/2/1999):
[TLI News Updated, 9/1/1999] - ViaGrowth-IV has passed testing.
ViaGrowth-IV, a combination of Paragon, ViaGrowth-I, and ViaGrowth-III, with extra Choline (9/2/1999), is on the way, under testing for highly performing, middle-ager and senior couplers which want to retain their dynamic orgasmic life with 3-5 times a week and refuse to grow old! Our goal is to help senior couples enjoy more funs in their golden age! Life is too short to fully enjoy being together.
Your Sexual Orgasm is our business. Please Feel Free to contact Dr. Lin.

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Missions:
=> Education of Love, Sex, Marriage, bioelectricity or life energy(the missing chapter in the modern medical textbooks which have been written based upon a corpse or an anatomical structure of the corpse), Naturopathy and Rejuvenation with Traditional Taoists' Wisdom - Give the 5000-year "Tao of Love" a trial: Your Success with us is our sexual orgasm(s) ; We can not limit our knowledge on a corpse. Instead, we have to study "life."
=> Helping Loving Couples, including the so-called Sex Experts, Therapists, Professors or Scientists, Solve Sexual Problems. It is FREE! We can train old dogs new tricks; We look beyond the so-called G-spot orgasm..
=> Research/Development of Naturopathic/Bio-Engineering Approaches for Solving Sexual Dysfunctions and Health Disorder, and Rejuvenating the Natural Body Functions -by promoting the parasympathetic function (the self healing power) and cooling down the sympathetic function for better health (of course, including SEX!)- that is, Cultivate your Chi (Qi or Ki) and love.
==> Help people reverse the side effects produced by medication drugs, painkillers, smoking , drinking, improper diets, birth control pill and injection, surgery, over-masturbation and over-ejaculation , resulting premature ejaculation and weak erection or impotence.
= => Help people solve chronic pain, fatigue, cramp, spasm, arthritis and non-disease health problems with the bioelectric theory.

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Safe Sex Advice for Young Women: My Finger Pliers Method can trigger the G-spot sexual orgasm without breaking the hymen!

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Dear Sex Experts, Therapists, Professors or Scientists:
Erectile dysfunction and sexual-orgasm disorder are physiological, not psychological!
We can make earth move!
Do your sexual problems always bother you?
Or, You don't know where is the G-spot, or cannot distinguish the G-spot from the Epicenter which has been named as the "Center of Lotus" by the old Taoists.
Or, you got divorce.
Or, Never have vaginal orgasm, or experience Premature Ejaculation, Erectile Dysfunction, or have a Shrinking Vagina or Penis, or a Prolapsing Uterus/Cervix causing pain/cramp in the pelvic cavity/low abdomen/low back/legs/butts.
And, you have nowhere to ask , just because your expertise is SEX. That is unfair to your soul.
We can help you out with the 5000-year Taoists' wisdom and the bioelectric engineering of the brain, nervous and endocrine functions plus the hydraulic engineering of the blood circulation - the plumbing problem of sex organs! It is FREE! We protect Your 100% privacy.
A combination of 5000-year love experiments and SEX 101 with the Dr. Lin's bioelectric engineering theory can not be wrong.
Sincerely yours, Lovebug.

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Sexual Orgasm Technologies, Methods and Treatment Programs:(WARNING: All the contents are copyrighted - File NOs: TX 4-698-609, TXu 824-686 and current filing in the US Copyright Office. For private use only. We reward your reporting on copyright violation. Academic/commercial uses of the contents in this website without written agreement are absolutely prohibited.)

1. Anal Breathing Intercourse and Screwing Technique - the Penile/Vaginal Mutual Massage (Kissing) Method, Sexual ChiKong Intercourse, Natural Penile Enlargement (Power-up or Ballooning) Method, Vacuum-Cupping Massage, and Herbal supplements (Natural Hormone Enhancers) for powering the brain function, curing premature ejaculation and prostate enlargement, penile/G-spot shrinking, weak erection/engorgement and impotence/frigidity, and for combating the chronic health problems, such as high-blood pressure, diabetes, pain and numbness in the neck, back, hands, fingers, waist, groins, butts, legs and feet, depression, side effects of drugs/medication/smoking/the erectile drugs,.. and so on; and

2. Finger Plier(2-Point excitation) Method, 3_point Excitation Method, Screwing Technique and Anal Breathing Method, Pressure and Vacuum-Cupping Massages, and herbal supplements (Natural Hormone Enhancers) for achieving multiple sexual orgasms, and for curing frigidity, vaginal dryness, vaginal shrinking, uterus prolapsing, thinning vaginal liner, prolapsed uterus, hysterectomy, Intercourse Pain, post-orgasmic cramp and pain, vaginismus,... and so on.