Prostaglandin E-2, induced by phenylethanolamine-N-methyl transferase and COX-2 gene over-expression, is responsible for premature ejaculation and premature sexual orgasm

Case Title: Prostaglandin E-2, induced by phenylethanolamine-N-methyl transferase and COX-2 gene over-expression, is responsible for premature ejaculation and premature sexual orgasm

Reader: 7/15/2005>
Dear Dr. Lin,

I choose writing you because I truly believe you provide enriching experiences to your readers. The internet is overcrowded with unconvincing testimonials, but in your website the abundance of cases supports your knowledge. Your scientific background shows and your kindness to share knowledge leaded me to ask for your help. For that matter I will try to be as pragmatic as I can:

For a long time during my puberty I haven’t had a girlfriend. That experience, or the lack of it, resulted in a precarious sexual education amplifying my insecurities. Now I have a girlfriend and somehow I’m really afraid I can’t perform (a problem which I believe we can solve together if we’re in love with each other). I’ve always suspected I suffered from PE, because I get excited really easy and my experiences with masturbation suggested me I wouldn’t manage to perform in a intercourse relationship, but somehow I always thought when I’d find someone I would deal with it and learned to be confident about it. Only there are evident symptoms that this case overrides psychological origin (though I understand psychology is determinant in equalizing hormone levels – parasympathetic nervous system).

. The very own idea of thinking about being with my girlfriend transforms me into a “loose canon”.
. My pre-cum fluids star running really soon and as long as foreplay endures (sometimes 4 to 5 hours resulting in really nasty pain)
. I ejaculate after a short period of stimulation; even when not penetrating. (which doesn’t surprise because I feel copula ready even before we touch each other)
. The erection doesn’t worry me though I feel a little bit tired after long excitability periods.

I understand this may have a strong psychological component involved. The test I usually run is thinking about really attractive long term “girlfriends” of mine with whom “I though my brain” not think sexually about them. I can touch them at a certain level of intimacy that my brain doesn’t fire. Now, if we’re talking about someone I fantasize or feel intellectually and physically bonded…

It came to my attention, when visiting your website, that my problem can be also related with my serotonin levels which induces the prostate to produce PG E-2 influencing Cowper’s Gland to release the fluid you refer to as pre-cum.

May this be the main problem?

May I have other structural problems influencing my sexual behavior?

I’m willing to run sexual contingency in order to re-educate myself. To do so will the Anal Breathing or the Sexual Chi Kong techniques be recommended?

Will I be able to do it without compensating with medicines?

I read that maybe some yoga asana (really similar to the exercises you suggest) and some Chinese Traditional Methods (Acupuncture) focusing on kidney and liver problems may help to…

I’d really appreciate your advice on this one, because I believe I will only find inner peace after I can feel I’m ready to connect sexually with my loved one.

For the time being I will try to manage with your 2 point stimulation techniques and hoping she understands the path I have to walk.

After the problem is solved (I do hope so) I will look closer to your improving techniques. ; )

I am very impressed with your work, combining physics/chemistry and engineering, reinventing a path for self knowledge and demystifying our sometimes esoteric complexity.

I’ll be waiting for your kind answer. With some anxiety I must confess (and this maybe one of the providers for my problem too)

Thank you very much,

Dr. Lin: 7/15/2005>The main problem is: when you become sexually aroused, your epinephrine release runs high, due to phenylethanolamine-N-methyl transferase gene over-expression, but your acetylcholine, serotonin and GABA are burning out. As a result, the COX-2 enzymes in your pelvic tissues, particularly in the prostate, seminal vesicles, Cowper's (bulbourethral) glands and urethra, become over-activated in producing excessive inflammatory hormone prostaglandin E-2. If this happens in your Cowper's glands, we will have excessive precum release; if this happens in your prostate, you will have semen leakage; if this happens in your seminal vesicles, you will have pelvic congestion pains.
As long as it happens in your the prostate, seminal vesicles, Cowper's (bulbourethral) glands or/and urethra, you will ejaculate very quickly. There is no way to control ejaculation when your prostate, seminal vesicles, Cowper's (bulbourethral) glands and urethra is inflamed by prostaglandin E-2.
If your prostate, seminal vesicles, Cowper's (bulbourethral) glands and urethra is erected by prostaglandin E-1, you will have a powerful erection to block the nervous transduction from your glans penis to your prostate and you will last forever until the long-last erection trigger the urethral and prostate tissue to release sufficient prostaglandin E-2. Prostaglandin E-2 release in the prostate, Cowper's glands and urethra can be induced tissue abrasion by chronic blasting of the poor-quality ejaculation jet. This is why chronic over-ejaculation can cause premature ejaculation, chemically and mechanically.
Anal breathing works when the prostaglandin E-2 release is not excessive, if the precum contains a balance prostaglandin E-1 and E-2, or if you had over-trained your prostate nervous reflexion by chronic masturbation or PC muscle exercises.
My experience with this condition is when you hold an erection too long, over an hour without a break, you will start to feel sore in your prostate and urethra and then release precum. Once the feeling starts, the sympathetic nervous system fires up Fight or Flight action and your penis may go limps or ejaculation in few minutes.
So, you cannot fight premature ejaculation whatever methods when your phenylethanolamine-N-methyl transferase and COX-2 gene over-expression

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