The neurotransmitter profile associated with erectile dysfunction and premature ejaculation, despite of a high testosterone and DHT level.

Case Study: The neurotransmitter profile associated with erectile dysfunction and premature ejaculation, despite of a high testosterone and DHT level.

Reader: 12/01/2007>Urine Test
Time 9:20AM

Epinephrine (µg/gCr) 8.0 (8 – 12)
Norepinephrine (µg/gCr) 53.5 (35-50)
Dopamine (µg/gCr) 188.5 (110 – 175)
Serotonin (µg/gCr) 109.2 (150 – 200)
Glycine (umol/gCr) 75.5 (200 – 400 )
Taurine (umol/gCr) 154.4 (150 – 550)
GABA (umol/gCr) 1.2 (1.5 – 4 .0)
Glutamine (umol/gCr) 217.6 (150 – 500)
Glutamate (umol/gCr) 16.2 (10 – 35)
Aspartic Acid (µmol/gCr) 22.6 (20 – 40)
PEA (nmol/gCr) 213.3 (175 – 450)
Agmatine (ug/gCr) 3.6 (1-2)
Histamine (ug/gCr) 20.4 (10-20)
Creatinine (mg/dL) 262.5 ( N/A )

Dr. Lin: 12/01/2007>As I expect, your norepinephrine and Dopamine too high and your serotonin and GABA level are too low, but your epinephrine was not fire up yet at when you collected the urinary sample at 9: 30 AM
Your premature ejaculation factors are: the high epinephrine, dopamine and histamine level, or/and the low serotonin and GABA.
The the high epinephrine, dopamine and histamine level over-excites your hypothalamus-pituitary axis for high oxytocin, testosterone and DHT level, and they over-excite the prostate for a fast ejaculation, in paricular, when your serotonin and GABA are too low to control the prostate.
Taurine is the precursor of GABA. Your Tarurine level is too low for the GABA synthesis.
Glycine is an inhibitory neurotransmitter in the central nervous system, especially in the spinal cord, brainstem, and retina. It can be considered the main inhibitor of motor neuron activity in the spinal cord. Blocking its action with strychnine results in uncontrolled muscle spasms, convulsions, and respiratory arrest. Glycine is a required co-agonist along with glutamate for NMDA (N-methyl-D-aspartic acid) receptors. In contrast to the inhibitory role of glycine in the spinal cord, this behavior is facilitated at the (NMDA) glutaminergic receptors which are excitatory. In this regard, you are OK since your glutamate level is within the normal range.

Your erectile problem is due to a high Agmatine level.
Agmatine inhibits nitric oxide synthase (NOS) responsible for the erectile neurotransmitter nitrc oxide production.
The major metabolic pathways for arginine involve primarily the conversion of L-arginine to L-citrulline by NOS, where Nitric Oxide is released; conversion of L-arginine to L-ornithine by arginas; and, conversion of L-arginine to agmatine by arginine decarboxylase (ADC). When your agmatine level is out of range, your nitric oxide production in the smooth muscle is likely shut down.

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