Overmasturbation resulted in Parkinson's symptom - restless or shivering legs and hands - due to abrupt drop of dopamine for excessive dopamine-neorepinephrine-epinephrine-DOPEGAL (3,4-dihydroxyphenylacetaldehyde) and dopamine-DOPAL(3,4-dihydroxyphenylacetic acid) conversion, leading to neurotoxicity and nervous death for no more sexual orgasm

Case Study: Overmasturbation resulted in Parkinson's symptom - restless or shivering legs and hands - due to abrupt drop of dopamine for excessive dopamine-neorepinephrine-epinephrine-DOPEGAL (3,4-dihydroxyphenylacetaldehyde) and dopamine-DOPAL(3,4-dihydroxyphenylacetic acid) conversion, leading to neurotoxicity and nervous death for no more sexual orgasm

Reader: 12/30/2007>i have been masturbating 4 times a week sometimes even 4 times a day My hands and legs started to shiver Do i have anything to worry Does it cause any physical problems

Dr. Lin: 12/31/2007>Yes.
This is a pesudo-Parkison's symptom due to an abrupt drop of the dopamine nervous function.
Sexual arousal, ejaculation or orgasm has induced excessive dopamine-norepinephrine-epinephrine or dopamine-DOPAL-DOPAC conversion, where DOPAL stands for 3,4-dihydroxyphenylacetaldehyde, and DOPAC for 3,4-dihydroxyphenylacetic acid (DOPAC) .
DOPAL is a potent neurotoxin to cause Parkinson's-like brain lesions, and its resulted cognitive impairment is very similar to autism.
In addition to DOPAL, norepinephine and epinephrine can be converted to 3,4-dihydroxyphenylglycoaldehyde (DOPEGAL). DOPEGAL has been found to trigger apoptosis and cause the loss of CNS neurons. Therefore, the synergic destructive effects of both DOPAL and DOPEGAL accelerates death of nerve cells, as seen in SIDS, Alzheimer’s, Parkinson’s disease, and dysfunctional disorders of development and aging.
Your over-masturbation practices has caused excessive DOPAL and DOPEGAL production.

PS: Dopamine is converted to DOPAL by monoamine oxidase (MAO), which is further oxidized to DOPAC acid via mitochondrial aldehyde dehydrogenase (ALDH). Norepinephrine and Epinephrine are converted to DOPEGAL by MAO.
MAO exists virtually in all mammalian cell types, with the notable exception of the erythrocyte, In humans there are two types of MAO: MAO-A and MAO-B. Both are found in neurons, hypothalamus, cerebral cortex (conscious control center), cerebellar cortex, pons, medulla oblongata, substantia nigra, caudate, astroglia, skins, and skeletal muscles. Outside the brain and central nervous system, the liver, gastrointestinal tract , adrenal glands, kidnes, heart, lungs, and placenta have about 60-90% MAO-A and 10-40% MAO-B, but, MAO-B is mostly found in blood platelets. MAO's are enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. MAO plays the key roles in the development of neurodegenerative disease, including not only its putative role in converting an exogenous protoxin to a toxin but also its role in the formation of peroxides generated from the oxidative metabolism of dopamine. MAO catalyzed deamination of dopamine to DOPAL and production of hydrogen peroxide (H₂O₂) depend on concentrations of dopamine within the cytoplasm. Hydrogen peroxide, if not detoxified by glutathione peroxidase, can be converted by iron-mediated Fenton reactions to toxic hydroxyl radicals ( -OH) that induce lipid peroxidation and cell death.

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