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News updated:
Case Study: Heavy-duty weight lifting can trigger excessive
norepinephrine and epinephrine elevation for inflammatory responses for penile
leakage and groin pains
Reader: 5/21/2008> first i inflamed my prostate with kegel exercises,
then with masturbation, now they it has inflamed again. (feeling like i have a
leak at the end of my penis and a sore grion) am taking your medication do you
think this occurance is due to wieght training? will it slowly improve, if my
problems ie pe are due to exercise, then that would explain alot as i have
trained alot over the past twenty years and had i chronic fatigue problem in my
early twenties. your thoughts.
Dr. Lin: 5/21/2008>
yes, weight training triggers excess stress hormones cortisol, norepinephrine
and epinpehrine release and then norepinephrine induce inflammatory hormone
prostaglandin E2 production for prostate inflammation. epinephrine induces
cutaneous mechanical hyperalgesia and sensitizes the dorsal root ganglion
neurons via its action at a beta-adrenergic
receptor and the effects of epinephrine are enhanced by both the
inflammatory protein kinases A and C second-messenger pathways.
some examples:
http://jap.physiology.org/cgi/content/abstract/87/4/1360
http://jap.physiology.org/cgi/content/full/96/2/531
http://content.onlinejacc.org/cgi/content/full/42/9/1656
http://circ.ahajournals.org/cgi/content/full/114/5/414
http://ajpgi.physiology.org/cgi/content/full/291/5/G877
http://jn.physiology.org/cgi/content/full/81/3/1104
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