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News updated:

Case Study: Why did he experience more intense of  high pitched tones and sounds when he gets upset?  - the  inflammation of the inner ear (cochlea, semicircular canals and vestibule)  induced by the stress hormone norepinephrine  and its elicited prostaglandin E2, histamine and glutamate - solution
Reader: 8/15/2009>
Would you be kind enough to answer another question? I have this continual high pitched tone or sound in my ears and head. It gets more intense when I am upset. Do you have any insight as to what may be causing this tone and how to get rid of it?
 
Thank you very much.
Dr. Lin: 8/15/2009>yes.
When your hypothalamic and adrenal dopamine-norepinephrine conversion elevates as your psychological and physiological stresses increase abruptly,  the prostaglandin E2, glutamate and histamine level will rapidly shoot up. Prostaglandin E2 and histamine are the arteries dilators as well as tissue inflammators and nervous stimulators while glutamate is the major signal generating neurotransmitter of the hair cells in the cochlea.  Prostaglandin E2 and histamine can inflame the inner ears to shift the resonant frequency of the inner ear to higher pitches tones by narrowing and shortening the inner hear, the chambers of the three semicircular canals, cochlea and vestibule, and sensitize the signal receiving and generating hair cells. The change of the cochlea's dimension due to inflammation will shift the dominant frequent of the resonant chamber to higher one.  If the inflammation and over-excitation occurs in your semicircular canals, you may get vertigo too.
The same effects can happen in your nasal cavity - respiratory tract and noses, and eyes.

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