Orgasm releases extra histamine by mast cells under the stimulation of norepinephrine due to an rapid conversion of dopamine-to-norepinephrine in the hypothalamus and adrenal glands during sexual encounter and even after orgasm.
The solution is: reduce abrupt dopamine-norepinephrine conversion, and inhabit its action on the adrenergic alpha receptors.

The receptors affected by histamine are given below.  H2 seems producing positive effects, but H1 can give you positive and some negative (such as itching, asthma, pain, dizziness, an so on) effect,  and H3, which serves as a feeback control of norepinephrine release but also negatively inhibit acetylcholine and serotonin release in the CNS for memory loss, depression and weak cholinergic/vegas and serotonin nervous control.  Thus, H1 and H3 receptors generate sexual exhaustion symptoms, although H1 receptors in the vaginal endothelial cells (particularly, around the G-spot) triggers the orgasm responses for the vagal nerves, and in the prostate, urethra, bulbourethral,  and seminal vesicles, it produces hypersensetive sensation and induces ehaculation urgency premature ejaculation or precum/semen leakage during sexual encounter .

Premature ejaculation is a very complicated tissue.
Main possible causes:
1. The prostate abrasion and poor seminal quality due to over-masturbation.
It requires a long-term prostaglandin E-1 therapy with Viapal-hGH-J (3-015) and 5-HTP (2-001) ,  plus Fish oil  (2-005) and Vitamin D(2-004) daily.
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2.  Drug abuse.
It requires a long-term nervous detoxification with Viapal-hGH-J (3-015) , DeToxiA (1-017) and 5-HTP (2-001), plus Fish oil  (2-005) and Vitamin D(2-004) daily.
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3.  a low  Serotonin level in the brain.
MoodMax and 5-HTP can help
4.  over-training of the nervous L1-L3 reflex arcs  of the PC and prostate muscles.
a long term Anal breathing practice can solve the problem
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5.  weak erection.
Power your erection with Viapal-hGH-J (3-015)

We use 5-HP,  ViaGrowth-III (or ViaGrowth-IV)+ MoodMax + DopaFIbra, Fish Oil (Omega-3 EPA  (647 mg) and Vitamins D 2000 IU and E 200 IU.
5-HTP + MoodMax + EPA  boost the cholinergic,  serotonin and GABA nervous control in the hypothalamic dopamine-norepeinephrine conversion, and power the parasympathetic nervous function to counterbalance  the sympathetic nervous function.
Our 5-HTP also contains a high dose of B3 (Niacin) to increase prostaglandin D2 production for relax the blood-brain tight junction for brain and nervous nutrients to penetrate into the brain and nervous system. Prostaglandin D2 also dilates arteries and capillaries for better blood circulation. B3 also increases the serotonin synthesis.
DopaFibra + ViaGrowth-III increase androgen hormones,  charge the central  dopaminergic nervous system and the parasympathetic nervous system,  and block the adrenergic alpha receptors, so that norpeinephrine and epinephrine can stimulate the adrenergic beta receptors for arterial dilation,  more blood https://www.rossitchpediatricdentistry.com/buy-lasix-online/ flow and beta-endorphin release.   Beta-endorphin in the brain and semen can cool down the sympathetic nervous function.
Fish Oil, Vitamins D and E will also increase testosterone and semen production.  They also change the semen chemistry by increasing prostaglandin E1 and E3 while reducing prostaglandin E2.
Reducing the sympathetic nervous function, increasing beta-endorphin/acetylcholine/serotonin/GABA/prostaglaninds E1/E2 and nadrogen hormone testosterone/DHT, and reducing norepinephrine/prostaglandin E2 will reduce histamine release.
Premature ejaculation, the sympathetic nervous fight response to sexual stimulation,  occurs when the prostate,  seminal vesicles, urethra, and  bulbourethral glands cook up more prostaglandin E2 and histamine, as inflammatory and sensitization hormones, in the synthesizing fluids (precum and semen)  under the sexual-induced excessive hypothalamic and adrenal dopamine- norepinephrine conversion.
We use the same formula to knock the bladder anxiety, over-reactive bladder, and stress induced incontinence.
There is another sympathetic nervous response to sex,  known as sympathetic nervous flight.  When the dopamine nervous function becomes too weak to stimulate the pituitary glands for sex, the pituitary gland releases insufficient oxytocin but excessive prolactin to constrict the arteries and retrieve the blood from the brain, penis and testicles, so that the penis goes limp.  The sympathetic nervous flight response to sex will force you to contract the PC muscles and the prostate to stimulate L1-L3 and S2-S4 for erection. Stimulation of L1-L3 sympathetic nerves activates the autonomic/sympathetic nervous reflex arcs in Discs L1 – L3 for precum release, semen emission and expulsion (ejaculation).
The solution for the sympathetic-nervous-flight-induced the sympathetic nervous fight is to block the autonomic nervous reflex arcs in Discs L1-L3 by my Anal Breathing training that alternates the autonomic nervous reflex arcs from L1-L3 to S1-S4.
Chronic masturbation for a fast ejaculation release usually trains the L1-L3 autonomic reflex arcs into a neuroplasticity state. If you got it, you have to ee-train your nervous reflex arcs.
Here are the references for Anal Breathing;
https://www.facebook.com/photo.php?fbid=10151708146338125&set=a.119650343124.125193.558153124&type=1&theater
http://www.youtube.com/watch?v=CMxQDc3VQA8
http://www.youtube.com/watch?v=stGUWgNwips

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