Sexual Differentiation And Ageing – The Broken Hypothalamic-pituitary-gonadal Axis

Sexual differentiation becomes more fuzzier when we grow older and older.
Male sexual differentiation is gone when the androgen hormone receptors in the hypothalamus-pituitary androgen hormonal feedback control loop are degenerated or become insensitive. That is, the hypothalamic-pituitary-gonadal axis is broken. Under this condition, the pituitary LH hormone remains low when the testosterone level is low. If The hypothalamic-pituitary-gonadal axis is still active, the pituitary gland will overshoot LH release in response to low serum testosterone. As a result, men will experience the so-called male “menopause” (andropause) symptoms produced by excessive LH, such as anxiety, sweating, sleeping disorder, mood swing, hot flushes, and so on, like women do in the midlife. The simplest pharmaceutical solution for male and female menopause symptoms is to break/castrate the hypothalamic-pituitary-gonadal axis with SSRIs antidepressants, that is to degenerate or desensitize the sex hormone receptors (testosterone receptors for men, or estrogen receptors for women) in the hypothalamus-pituitary axis. Breaking the hypothalamic-pituitary-gonadal axis will disable the sex hormone feedback control loop in the hypothalamic-pituitary-gonadal axis, so that the pituitary gland won’t release excessive LH in an attempt to reactivate the testicular/ovarian function. Thus, SSRIs performs chemical castration of the hypothalamic-pituitary-gonadal axis. A good or bad idea?
Therefore, old men become femalized (grow the breasts and shrink the penis), and lose muscles, bone density and manhood. Old men will no longer have to worry about erection or penile enlargement!.

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