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Chronic over-masturbation, over-ejaculation or excessive orgasm generally burn out your dopamine, cholinergic/vagal(acetylcholine) , serotonin and GABA nervous control with excessive hypothalamic and adrenal dopamine-norepinephrine conversion for constant sympathetic nervous fight or/and flight, excessive norepinephrine-induced informatory hormone prostaglandin E2 production over your body cells from your head to your toe, excessive norepinephrine-induced Immunoglobulin (antibodies such as IgA, IgD, IgE, IgG and IgM) elevation for neuroimmune weakness and disorders, constant elevation of the pituitary prolactin release for autoimmune disorders, and constant constriction and inflammation of your arterial and heart smooth muscles.
Chronic elevation of sex-induced excessive norepinephrine and prostaglandin E2 in the limbic system and central nervous system with a weak serotonin and GABA nervous control result in brain evolution, known as neuroplasticity, for addiction of sexual pleasure rewarding; with the neuroplasticity, excessive sympathetic nervous and prostaglandin E2 stimulation on the sex organs, such as the penis, prostate,  and seminal vesicles for men and the clitoris, vagina, cervix and uterus for women,  facilitate constant in-heat inflammation and erection for persistent sexual arousal for frequent, sexual orgasmic addiction. To reverse the brain evolution of sexual addiction, you will have to power up your cholinergic, serotonin and GABA nervous control on your hypothalamic and adrenal dopamine-norepinephrine conversion.  Brain evolution is a long-term process. It can be in either the positive or negative direction, depending what stimulation the brain and central nervous system get. Generally, cholinergic/vagal nervous stimulation in conjunction with restoration of serotonin and GABA nervous control will produce positive brain evolution for good.
Over-masturbation/over-ejaculation/excessive-orgasm can castrate the hypothalamus-pituitary-testicular(ovarian) axis by arterial constriction and inflammatory narrowness in your brain and pelvic organs (testicles, prostate, seminal vesicles, penis, ovaries, uterus, vagina and clitoris) due to excessive release of prolactin, norepinephrine, and epinephrine, excessive binding of norepinephrine/epinephrine on the alpha-adrenergic receptors, the norepinephrine/epinephrine induced excessive prostaglandin E2, and the post-sex deficiency of nitric oxide and prostaglandins E1/E3 production. As a result of arterial constriction and inflammatory narrowness (leading to arterial thrombosis and atherothrombosis!
http://jem.rupress.org/cgi/content/full/204/2/311;
http://jpet.aspetjournals.org/cgi/content/full/300/2/393;
http://jem.rupress.org/cgi/content/full/204/2/311  ),
your brain, testicles, penis, (clitoris, vulva, G-spot, vagina, uterus and ovaries for women)  feet and hands get low blood supplies and less androgen hormones and nuerochemicals, but more inflammatory hormone production and stress hormones.  And, it will take a long time for you to get recovery from sexual exhaustion and post-sex inflammation. You may also wonder why your  penis or clitoris go limps and your vagina become dry in the middle of sex.  When your adrenal and testicular (or ovarian) function are disabled, you will have to rely on the skin neruoendocrine function to elevate your androgen hormones.  Please also note that prostaglandin E2 also inflame veins too – http://atvb.ahajournals.org/cgi/content/full/18/10/1655,
http://ajpcell.physiology.org/cgi/content/full/281/3/C1038,
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=199422, and
http://atvb.ahajournals.org/cgi/content/full/17/9/1644 . When you get inflamed arteries and veins, your blood circulation won’t reach the inflamed areas and you will experience pain, numbness or cramp .  As for sex, you don’t want inflamed arteries and veins in your penis and testicles (clitoris, labia, G-spot,  vagina. uterus (and its support ligaments and tissues) and ovaries for women), do you?

In addition, excessively accumulation of prolactin as a result of  high-frequency ejaculation or orgasm disables the activin release from the testicles, epididymis, prostate,and seminal vesicles (or ovaries for women),  leading to a low pituitary FSH release, followed by a low pituitary LH release, resulting in deficiency of androgen hormonal production from the testicles and ovaries. On the other hand, activin is a negative regulator of prolactin and cell growth ( http://mend.endojournals.org/cgi/content/full/18/6/1558 ). Without sufficient activin, the excessive release prolactin becomes persistent,  and thus the androgen hormones (testosterone and DHT) level remains too low to help the exhausted hypothalamus-pituitary-adrenal and testicular (ovarian) axis to recover from sexual exhaustion or post-sex illness or to suppress the inflammatory pains. No wonder, you will experience persistent  sexual exhaustion, fatigue, tiredness and inflammatory pains. 

Excessive orgasm, over-masturbation or over-ejaculation over-discharges the brain’s acetylcholine, dopamine, and serotonin nerves systems, resulting in brain’s/nervous (pro-sympathetic, due to over-conversion of dopamine to norepinephrine and epinephrine for stress responses), liver, cardiovascular, kidney, and endocrine disorder, and then burns them out with chronically excessive norepinephrine/epinephrine/sympathetic nervous fires, the induced inflammatory hormone prostaglandin E2, glutamate, histamine,  3,4-dihydroxyphenylacetaldehyde (DOPAL – http://parkinsons.hopedigest.com/blogs/scientists_indict_dopal_as_cause_of_parkinsons_disease
); dihydroxyphenylacetic acid (DOPAC –
http://www.ohiolink.edu/etd/send-pdf.cgi?acc_num=kent1164141349 and
http://www.ingentaconnect.com/content/bsc/jnc/2002/00000081/00000004/art00023
),3,4-dihydroxyphenylglycolaldehyde (DOPEGAL –
http://pharmrev.aspetjournals.org/cgi/reprint/56/3/331) and 3,4-dihydroxyphenylglycol (DHPG –
http://pharmrev.aspetjournals.org/cgi/reprint/56/3/331 ).
Your brain/neuro-endocrine and liver systems are like an over-discharged good-old-day car battery (overcharge causes chemical/mineral deposits on the electrodes of acid batteries made before 1980 and ruin them)  which won’t start the engine to perform recharging for itself.  Some nervous cells are burned out or damaged by the nervous excitotoxicity and inflammation byproducts listed above.   As a result of the exhaustion of your pituitary-adrenal and -testicular axis,  the production of your androgen hormones (DHEA, androstenedione testosterone and DHT) and pituitary oxytocin become too low to support your neuro-immune function and to suppress the inflammatory hormone prostaglandin E2 release from your body – typically from your brain/head/neck, your pelvic organs, and your internal organs between your neck and pelvic cavity.  The excess- orgasm or over-ejaculation induced prolactin,  cortisol, norepinephrine and epinephrine,  if excessive,  can disable the pituitary-testicular (or -ovarian) axis for a few days or even months, leading to a long refraction time or a long-term sexual exhaustion and inflammation.  Even, excessive prolactin,  cortisol, noepinephrine and/or epinephrine in the bloodstream can induce excessive prostaglandin E2 release from the tissues. In fact, chronic elevation of epinephrine and prostaglandin E2 result in nervous excitotoxicity and cellular damage in the brain cells and the vagal or parasympathetic nerves in the liver, lungs, adrenal, heart, blood vessels, digestive system, pancreas, gallbladder, ovaries, uterus, cervix, testicles and prostate.  Men also suffer from deficiency of the key semen chemicals such as potassium, zinc, calcium, magnesium, citric acid, androgen hormones (DHEA, androstenedione, testosterone and DHT), fructose, phosphorylcholine (for the brain/memory/vision/hearing/nervous sensing systems), spermine, prostatic acid phosphatase, free amino acids (most important ones includes GABA, glycine,  agmatine and 5-HTP associated with brain/liver/adrenal/testicular functions, vision, hearing,  sympathetic nervous control and mood) , prostaglandins (prostaglandins E1 and E3 for the elasticity and flexibility of tissues, nerves and blood vessels) and enzymes that support the androgen hormones and neurotransmitter syntheses. Unfortunately, the sexual exhaustion symptoms and inflammatory responses are a result of a low DHEA, androstenedione testosterone,  DHT and/or oxytocin with a high or excessive level of prolactin, cortisol, norepinephrine and epinephrine, although you won’t see a drop of your androgen hormones in couple hours right after the orgasm-induced prolactin and cortisol release.  However, you may experience the  pro-inflammatory neuro-immune responses to the sex-induced stress hormones norepinephrine and epinephrine  during sex arousal and orgasm/ejaculation  or even several days by activating  a group of proinflammatory cytokines such as IL-1, IL-1ß, IL-6, TNF-, IFN-, and MIP-1 and protein kinases A and C  in the the immune system via the alpha- and beta-adrenergic receptors in cells.  The proinflammatory cytokines, acting as the endogenous pyrogen of desire fires, can trigger excessive norepinephrine-induced prostaglandin E2 production in the adrenergic receptors everywhere, from your scalp down to your toes. And then epinephrine will induces cutaneous mechanical hyperalgesia and sensitizes the dorsal root ganglion neurons via its action at a -adrenergic receptor and the effects of epinephrine are enhanced by both the inflammatory protein kinases A and  C second-messenger pathways for enhancement of inflammatory responses.  When the elevated prolactin, cortisol, norepinephrine and epinephrine constrict your arteries to your liver,  kidneys, adrenal glands and testicles (ovaries for women) after sex, your adrenal and testicular (or ovarian) function will be disabled or shut down for many hours or days –http://action.love/#Ejaculation%20Frequency%20vs.%20Testosterone%20Level
Suppression of androgen hormones production by excessive prolactin and cortisol, in conjunction with constriction of the arteries in the brain, liver, adrenal glands and testicles, will continue weakening your neuro-immune reaction for proinflammation, and prolong your recovery time and post-orgasm/post-ejaculation exhaustion and illness –http://action.love/#Sexually%20Stress-induced%20Inflammatory%20Pains,
%20Headaches%20and%20Hangover  Warning: sexual arousal, ejaculation or orgasm won’t decrease your androgen hormonal level in the bloodstream immediately. If sexual arousal fires up your cortisol and prolactin to let your penis go limp (the sympathetic nervous Flight response to sexual stimulation and stress), you give up sexual activities immediately. This is because the elevation of prolactin and cortisol block your hypothalamus-pituitary-adrenal and -testicular axis which are supposed to fire up oxytocin, DHEA, androstenedione, testosterone and DHT production for your ongoing sexual excitation and orgasm. I consider that going limp  during sex is a natural protection of your hypothalamus-pituitary-adrenal and -testicular axis.  If you force yourself to ejaculation or orgasm after your experience the erectile dysfunction during sex, you will be in trouble. This is because, once androgen hormones in the bloodstream are used up and become too low to support your brain/nerves, internal organs and joints/muscles, you will start to experience the post-orgasm/post-ejaculation sexual exhaustion symptoms.  Generally, these symptoms start to show up at about 3-8 hours after ejaculation or orgasm. The symptoms can last for 3-10 days until your brain’s hypothalamus-pituitary-adrenal and-testicular axis start to kick in. During this suffering period, you have to rely on your skin/tissue’s Cutaneous Hypothalamus-Pituitary-Adrenal (CHPA) function to assist post-ejaculation or post-orgasm recovery. Due to the link of the hypothalamus-pituitary-thyroid axis, you may also experience the symptoms associated with thyroid disorders. You will also like to experience hair loss too ( http://action.love/extra/hailoss.htm  ) For the functional equivalent of human hair follicles to the hypothalamus-pituitary-adrenal (HPA) axis, please readhttp://www.fasebj.org/cgi/reprint/04-1968fjev1 (also http://edrv.endojournals.org/cgi/reprint/21/5/457). When excessive sex stressed out your HPA, it also burned out your hair follicles, in particularly, with a high DHT, inflammatory hormone prostaglandin E2, cortisol, norepinephrine and epinephrine level and with a constriction of the blood vessels in your scalp when chronic prolactin, norepinephrine and epinephrine level run high.  You can get more information form the home page of  http://action.love for more detail. Using prescribed erectile drugs, the PDE-5 inhibitors,  to assist erection for sex will mess up your neuro-endocrine function for sexual exhaustion. 
Please also note that the extremely exhausted adrenal function can cause an extreme low level of  DHEA, endophrin and cortisol. An abnormal cortisol level or a lack of endorphin indicates the adrenal function disorder, fatigue or excessive orgasm/ejaculation induced stress. Excessive orgasm or over-ejaculation can produce a transient shooting or cortisol and epinephrine and result in a long-term effect on the adrenal function, although the cortisol output may become too low or too high few days after sexual activities, with a constant elevation of epinephrine released from the hypothalamus and the adrenal medulla.  It should be aware that prostaglandin E2 is an immune suppressor, as well as an nervous excitor.  Excessive prostaglandin E2 in the bloodstream causes not only inflammatory, but also weak neuro-immunity.   As a result, sexual exhaustion produce multiple symptoms which become UFO for the western doctors and medical societies since the western doctors and medical societies fail to realize the root of the problems, “enjoying too much sexual pleasure.” If you don’t go after the root of the problems, there is no way to solve the sexual exhaustion symptoms. For more information or our over-10-year collection of sexual exhaustion symptoms, please go to
http://action.love/extra/over.htm
http://action.love/extra/over2.htm  and
http://action.love/extra/girloversex.htm

Orgasm induces immune challenge in 2 ways: direct and indirect. The direct one is to respond to the foreign substances bringing to the contact organs including the mouth and sex organs. The indirect one is a neuro-immune response to the orgasm induced norepinephrine release from the hypothalamus and adrenal glands, leading to the elevation of Immunoglobulin (antibodies ). The problem is: Chronic elevation of the stress hormone norepinephrine and its induced immune suppression will collapse the immune system. There are several symptoms associated with excessive norepinephrine-induced Immunoglobulin (antibodies such as IgA, IgD, IgE, IgG and IgM) elevation and excessive immune-suppression prostaglandin E2 for neuroimmune weakness and disorders. For sexual induced asthma, sneezing, allergy and sinus, we will have to deal with the excessive norepinephrine induced IgE which triggers excessive release of both histamine and prostaglandin E2.
The antibody IgE, which is found in the lungs, skin, and mucous membranes, is responsible for activation of mast cells to release histamine,  and  for triggering cytokines like interleukin-4 (IL-4) and interleukin-13 (IL-13) and other inflammatory mediators to release inflammatory hormone and immune-suppressor prostaglandin E2.  Thus, overshooting of IgE causes allergy, sneezing and hypersensitivity.  Elevation of the stress neurohomrone norepinephrine will generally trigger the elevation of IgE for allergy, sneezing and hypersensitivity,  and activates enzyme Cyclooxygenase-2 (also known as COX-2) to oxidize arachidonic acid into prostaglandin E2.  Excessive psychological or physical stress, excessive sex, over-exposure to sunlight or intensive heat, air pollution, or pollen can overshoot IgE for allergy, sinus, headaches and other inflammatory diseases.
IgM is found in blood and lymp fluid in response to an infection. It promotes other immune system cells to destroy intruders. However,  Excessive elevation of IgM indicates ectodermal dysplasia and immunodeficiency, or humoral immune defect.
IgG is found in the body fluid, very important in fighting against bacterial and viral infections. Norepinephrine is not supposed to increase IgG antibodies.
IgA is found in the areas of the body, that exposed to foreign substances. Those areas include the nose, breathing passages, digestive tract, ears, eyes, and vagina. IgA antibodies protect the body surfaces  against outside foreign substances. Sexual intimacy may elevate IgA  in response to the secretion from the mouth, vagina, uterus and  cervix and other sexual aid substances for men, and to the secretion of mouth, the ejaculation fluid and sexual aid substances for women. It is supposed to be an immune challenge.
Chronic over-stimulation of the immune system with excessive stress neurohormone norepinephrine and its induced immune suppressor prostaglandin E2 will breakdown the immune adaptive ability  and collapse the the adaptive immune system, leading to immune disorders. Thus, if your norepinephrine and prostaglandin E2 are not overshooting, immune stimulation with norepinephrine will improve the adaptive immune system to combat pathogens, the alternative term “infectious agents” or the common name “germs.”
The other immune complements of the innate immune system,  known as the complement system which is not adaptable and won’t change overtime in an individual’s lifetime, can be recruited and brought into action by the adaptive immune system. The complement system is a biochemical cascade that clears pathogens by attacking the surface of foreign cells. It contains over 20 different proteins, circulating in the blood and bathing the tissues in an inactive form.  In response to the recognition of  foreign cells, the proteins become sequentially activated, working in a cascade  in which the binding of one protein will promote the binding of the next protein in the cascade. It is the major humoral component of the innate immune response.
The complement cascade is a double-edged sword.  While protecting against the invasion of foreign cells, the complement system has the potential to be extremely damaging to host tissues via its induced inflammation and phagocytosis. A long-term stimulation of the complement system may lead to many diseases associated with an immune component, such as Barraquer-Simons Syndrome, asthma, lupus erythematosus, glomerulonephritis, vasculitis (inflammatory destruction of blood vessels including both arteries and veins)), kidney basement membrane diseases, nephritis (kidney inflammation), hemolysis (rupture of red blood cells), arthritis, autoimmune heart disease, multiple sclerosis, inflammatory bowel disease,  ischemia-reperfusion injuries, and autoimmune disorders,   and to the diseases of the central nervous system such as Alzheimer’s disease, Parkinson’s diseases,  parkinsonism,  and other neurodegenerative conditions.

The sexual exhaustion symptoms include:
1. daily or orgasmic/ejaculation pains or cramps in pelvic cavity – including low back, tail bone, perineum, groins, perineum, penis (clitoris/vagina for women during penetration, intercourse, orgasm or post orgasm), testicles, low abdomen, neck/shoulders or rear brain (or whole head)– due to a lack of the relaxation and tissue-elastic hormone prostaglandin E-1 synthesized by the local tissues, an abrupt drop of the brain’s neurotransmitters acetylcholine, dopamine, serotonin and GABA, or an excessive conversion of the dopamine->norepinephrine->epinephrine.
2. depression, stress , anxiety, and emotional instability (Mood Swing)  – due to deficiency of the neurotransmitters acetylcholine, dopamine, serotonin add GABA.
3. Attention Deficiency and Absence mind (losing mind concentration and memory) – due to the deficiency of the brain’s neurotransmitters serotonin and acetylcholine – memory protection failure or insufficient memory.
4. eye floaters or sun-light sensitive eyes, blurred vision  or sympathetic nervous pupil dilation  – due to disorders of the nervous sensing (acetylcholine nervous)  and amplifier (dopamine nervous) circuits,  a deficiency of the serotonin/GABA nervous modulation in retina, excessive stress hormones, or a poor retinal blood circulation or an arterial constriction due to deficiency of prostaglandin E-1 or/and Nitric oxide or sympathetic nervous action on the beta receptors, or an excessive inflammatory hormone prostaglandin E2 release induced by deficiency of the androgen hormones or excessive stressors cortisol or epinephrine.
5. buzzing ears – the same as Item 4..
6. less or no seminal/lubrication production (vaginal dryness for women and VAGINISMUS ),  weak ejaculation or ejaculation dysfunction – watery ejaculation or no ejaculation or orgasm – due to the neuro-endocrine disorder resulting from the weakening liver, adrenal, prostate and testicular (ovarian) functions.  This is the destruction of seminal production mechanism for men. For women, it is due to a low estrogen and androstenedione/testosterone/prostaglandin E-1/oxytocin or/and a high progesterone level in the bloodstream.
7. weak erection or youth impotence.
8. low libido, exhaustion and fatigue  due to deficiency of the brain’s neurotransmitters dopamine, acetylcholine and serotonin and a lack of oxytocin.
9. prostatitis or urethitis ( the abrasion of the prostate or urethral duct; easier to have prostate/urethral/bladder infection) , urinary or bowel incontinence, pelvic pains (Interstitial Cystitis (IC) , testicular pains, penile pains, andclitoral numbness or pains as a result of excessive inflammatory prostaglandin E-2 release with a deficiency of healing hormone prostaglandin E-1 – disorders of the 3rd brain – the pelvic parasympathetic nerves S1-S5 and Co and the serotonin nervous modulators for the sympathetic T10-L2,  particularly the L1 and L2 nervous branches to the bladder, urethra, prostate, bulbourethral glands, Great Vestibular glands, Urethral glands (de-generated seminal vesicles), clitoris, vagina, uterus and rectum/anus.  men produces excessive pre-cum and women are vaginally over-wetted.  Men or women may experience sex-/orgasm-induced stress incontinence (leakage or ejaculation of urine during sex or orgasm).
10. penile (clitoral or G-spot for women) shrinkage ( or vaginal enlargement or loosening for women) – due to atrophy of spongy tissues caused by nervous damage, deficiency of acetylcholine or/and Nitric Oxide,  or excessive stress hormone in the sympathetic alpha receptors.
11. unwanted penile bending and shrinking (the clitoral/G-spot death and shrinkage)- formation of the scar tissues due to tissue and nervous abrasion .
12. premature ejaculation – damage of the prostate/urethral nerves and duct, and burning-out (drop) of the serotonin and acetylcholine level in the brain and nervous synapses.
13. premature hair loss or decoloring.
14. short breathing and irregular cardiovascular output (sympathetic) – a weakening brain’s acetylcholine/serotonin and parasympathetic/vagus nervous function.
15. white or violet nails – deficiency of Zinc.
16. weak immunity – neuro-immune disorder resulting from the deficiency of the neurotransmitters acetylcholine (Yin Chi) and dopamine (Yang Chi).  For example, easy to catch cool or get sick and requiring a longer time to get recovery from sickness.
17. Sleeping disorder and its associated symptoms- due to the deficiency of serotonin and melatonin, both of which are synthesized by the pineal gland with GABA and norepinephrine, or due to excessive pituitary LH and FSH hormones in an attempt to revive a weak/dying testicular/ovarian function, or due to excessive Yang-type stressor epinephrine in the cerebrospinal fluid. This causes a deficiency hGH and excessive inflammatory hormone prostaglandin E-2 release into the bloodstream, an undercharging of the parasympathetic nervous system, and an excessive sympathetic nervous fire (Flight or Fight), resulting in back/joint/ligament pains or cramps, urinary or bowel incontinence, Irritable Bowel Syndrome (IBS),  prostatitis or urethritis, as a result of no or insufficient healing (restoration)  power (prostaglandin E-1) in the organs. muscles, ligaments and joints. Please note that excessive Ying-type stressor cortisol causes hGH, DHEA and testosterone deficiency and  induces drowsiness over-sleeping, blurred vision, and hangover.
18. organ functional disorders in the 2nd brain (between the neck and pelvis) due to the weakening of the vagus (parasympathetic) nerves and the weakening serotonin nervous modulation on the sympathetic nervous functions – the most typical ones are: digestive , cardiovascular and liver systems; some experience the gallbladder and pancreas functional disorders too. The most visual or sensible disorder is stomach pain or digestive panic.
19. Excessive Sweating – the sympathetic/epinephrine nervous fires burning the entire body due to an constantly excessive dopamine/norepinephrine-epinephrine conversion in the hypothalamus and adrenal medulla.
20. Headaches or migraines – due to excessive inflammatory hormone prostaglandin E-2 release and excessive dopamine/norepinephrine-epinephrine conversion in the brain after the acetylcholine, serotonin and GABA nervous system were exhausted by excessive sex.
21. Fatigue, tiredness and exhaustion – the parasympathetic nervous recharging/healing system is out of order; the pituitary releases excessive prolactin to shut down the testicular function.
22. Muscle weakness – due to deficiency of DHEA, testosterone or DHT. This results from exhaustion of the hypothalamus-pituitary-adrenal and/or testicular axis.
23. Muscle Tremors/Twitching (pre-Parkinson’s symptoms) – due to deficiency of dopamine and acetylcholine.
24. Weak neuro-immune function and persistent inflammation – easy to get infection or catch flu or cold, sinus, allergy, or/and sore throat.
25. Kidney inflammatory pains – orgasm over-stimulates the immune complement system, resulting kidney inflammation.

A weak adrenal function can constantly convert dopamine into norepinephrine and epinephrine for sympathetic nervous fire even your hypothalamus won’t get stimulated or excited. The Traditional Chinese Medicine terms this phenomenon as “Weak Kidney” .

(References: Sato, A. “Neural mechanisms of somatic sensory regulation of catecholamine secretion from the adrenal gland.” Adv Biophys. 1987;23:39-80. http://www.ncbi.nlm.nih.gov/pubmed/3326403

The effects of THC and testosterone on erectile function during copulation

This is a question from a 50-year-old marijuana user which experience erectile dysfunction and premature ejaculation while his testosterone level is 1300 ng/dl.  Based up our collection of similar cases in http://action.love/extra/marijuana.htm, we can conclude the erectile function, despite of a very high testosterone level,  results from the blunted dopaminergic function  by THC. Premature ejaculation is a result of excessive prostaglandin E2 and histamine in the prostate fluid and the bulbourethal fluid (also known as precum). Both  prostaglandin E2 and histamine turn on the sympathetic orgasm/ejaculation nervous control reflex in Disc L1-L3 from its sensory input in  the urethra, prostate and seminal vesicles. Reader’s Question:
I’m a 50 year old male who has been dx with transverse myelitis in my T-11 area. My testosterone level is 1300. I smoke Marijuana for depression.  My pens won’t fully balloon and seems to have leakage.  Also I leak pretty cum fluids only being half errect. During masterbation the ejaculate nerve seems real intense and I ejaculate quick and then I’m able to ejaculate https://www.glenerinpharmacy.com/buy-cipro-online/ again without being errect.  Help, what can I do? My sec life is at an all time low.

Dr. Lin’s Answer:
Zenegra completely erases online prescriptions for cialis the specific lovemaking predicament. Look for certification: While seeking to buy a pump, make sure that the manufacturer offers you the highest grade make with safety assurance by a recognized generic levitra without prescription organization. The pancreas secretes the hormone insulin to allow the cells viagra best buy to use glucose. Understanding what causes impotence is the first step into finding the right medicine to deal with your impotence, come and buy levitra uk and live a happy life. Although your T10-T12 sympathetic nerves do  interfere with your erectile function to some degrees,  marijuana THC causes erectile function by blunting your central dopamine, norepinephrine and epinephrine nervous responses to stimulation.  This means THC also knocks down your sympathetic nervous function.
The erectile function depends on the central dopamine nervous action on the NOergic , vagus/parasympathetic and sympathetic nerve,  while androgen hormones testosterone and DHT are just for maintaining the integrity of the erectile smooth muscle. This can explain while your high testosterone level won’t give you a proper sexual response.
You should quit marijuana, and take ViaPal-hGH-P(3-010) and ArgiNOx (1-018), plus Omega-3  Fish Oil(2-005) and Vitamin D (2-004),  to help you gradually rejuvenate your dopamine nervous function and  boost your prostaglandin E-1/E-3 and Nitric Oxide production for healing.  This formula is for antidepression too.
http://action.love/mail/herbform.htm

PS: During copulation, dopamine plays the key role for the brain and genital arousal.

Peyronies Disease – Deformation or hardening of genital smooth muscle with uneven distribution of collagen scar tissues over the smooth muscle

Peyronies Disease is generally referred to the male genital deformation, but women have the similar problem – deformation, thinning or hardening of the genitourinary smooth muscle, which results in incontinence,  dryness, looseness, prolapse, dyspareunia or vaginismus, although it is invisible.

OK, first let’s consider the male problem.

The penile smooth muscle, like arterial ones,  can repair or regrow itself  via the stem cell’s  transforming growth factor-beta(3) (TGF-beta3) which regrows the local cells like embryo does . However, due to the penile blood flow restriction, or androgen hormone deficiency, or excessive drug toxins, there are insufficient active stem cells around the damaged tissue to release TGF-beta3  for regenerating the smooth muscle.  As a result, The damaged  (also, “nutritionally starved” ) cell  releases collagen protein, and activates cellular transforming growth factor-beta(1) (TGF-beta1) for a faster reconstruction and  reconnection of the damaged tissue.  This will further restrict the genitourinary blood circulation for more deformation, shrinkage, scarring and thinning of the smooth muscle. Ref: http://www.ncbi.nlm.nih.gov/pubmed/15291880

Chemical or mechanical damage, or degeneration of penile smooth muscles due to deficiency of androgen hormones (testosterone and/or DHT) or/and erectile factors ( nitric oxide (NO) and prostaglandins), is likely to disable the stem cells which result in activation of TGF-beta1 instead  of TGF-beta3. The embryo TGF-beta3 can multiply or duplicate the smooth muscle cells without a presence of collagen scar tissues.  Embryo TGF-beta3 helps a baby heal any wounds or cuts without any scars. As we get old, we will have less and less TGF-beta3, in particular,  in the genital smooth muscle cells which requires a lot of human growth hormones, androgen hormones, nitric oxide and prostaglandins to maintain the integrity of the smooth muscle.  If you can increase the cellular TGF-beta3 activities in the smooth muscle, you can or repair or regrow it, like a baby and puberty teenager does.

Chemical damage of penile tissues can be caused by medication or street drugs, diabetes, high stress hormones or prolactin,  and deficiency of oxytocin, hGH, DHEA, testosterone and DHT in the bloodstream.  The most destruction medication drugs for the penile smooth muscle include the beta blocker, 5-alpha reductase inhibitors (for hair regrowth or prostate enlargement), and LDL cholesterol lowering drugs.  Beta blockers constrict the penile arteries for poor blood circulation; 5-alpha reductase inhibitors cause DHT deficiency; the LDL lowering drugs result in deficiency of DHEA, testosterone and DHT.  On the other hands, all the street drugs are likely to cause severe damage of the smooth muscle by either disabling the hypothalamus-pituitary-testicular axis, killing the erectile nerves, enhancing the inflammatory hormone prostaglandin E2 synthesis while reducing the synthesis of other prostaglandins,  or even poisoning the adult stem cells.

Mechanical damage of the penile smooth muscle is very common for men who practice penile stretching or pumping.  When the smooth muscle matrix is forcefully stretched or expanded beyond its elastic capacity, collagen protein is released in an attempt to repair the damaged smooth tissue. In stead of repair, collagen protein hardens the damaged spot.   In addition to the over-strained damage, the smooth muscle can become fatigue when the tissue is subject to high-frequency vibration, even if the amplitude is small. Collagen protein starts to release all over the smooth muscle when the smooth muscle become fatigue.  This will result in reduction of the erectile ability of the smooth muscle, ending up with with hardening and shrinkage. Vibrator abusers, men or women, are likely to experience erectile dysfunction of the smooth muscle in the penis, urethra, clitoris or vagina. It also destroys or hardens the vagus nerve, leading to urinary or bowling incontinence.

The smooth muscle can become hardened in certain zones or spots.   For men, the collagen scar formation produces a crooked/bent or hour-glass shaped penis. For women, it results in external genital shrinkage and hardening, thinning (or scarring) of urethral and vaginal smoothing muscle, and vaginal enlargement. This is the female Peyronies Disease!  Since the female genital smooth muscle is hidden above the pelvic flood muscle, women won’t be aware of the Peyronies Disease even if they experience incontinence,  dryness, looseness, prolapse, dyspareunia or vaginismus!

Once we understand the causes of the problem, we can re-model them by activating the adult stem cells in the smooth muscle for TGF-beta3, accordingly:

1. take need ViaPal-hGH-P(3-010) and ArgiNOx (1-018), plus Omega-3  Fish Oil(2-005) and Vitamin D (2-004),  to help you gradually rejuvenate your neuro-endocrine function (increaseing testosterone and DHT level) and  boost your prostaglandin E-1/E-3 and Nitric Oxide production for healing. http://linstitute.apollohosting.com/store/index.html

(why should you maintain an above-averaged androgen hormone level?  please read
“Effects of Androgen on the Expression of Vascular Endothelial Growth Factor in the Penile Corpus Cavernosum”
by Eu Chang Hwanga, Kyung Jin Oha, Seung Il Junga, Noel N. Kimb, Kyu Youn Ahnc, and Kwangsung Park,
Urology, Volume 77, Issue 6, June 2011, Pages 1381–1386
http://www.sciencedirect.com/science/article/pii/S0090429511001099 )

and
2. Practice genital ballooning and massage with VIP Cream (1-015) to increase the smooth muscle blood flow, to stimulate the NO and prostaglandins release, and to  soften the hardened tissues. http://action.love/WordPress/2014/02/25/theory-of-penile-ballooning-enlargement/  or
http://action.love/extra/enlarge.htm
There are cases in which the reasons for a cialis properien product’s success are obvious. It not only saves you from the embarrassment, but you can also find a range of quality products at affordable prices.You may purchase generic viagra find some of the online sellers offering discounts and deals. In deciding whether you’re experiencing Low T symptoms, our hormone replacement therapy doctor and medical staff will ask you several questions and makes you go http://seanamic.com/seanamic-group-drives-forward-with-services-expansion/ best soft cialis under many tests, after which he would determine the actual reason behind your problem and cure you accordingly. When people take seanamic.com order levitra online Tums, Rolaids, Prilosec and other antacids, the necessary digestive enzymes are diminished.
Noticeably, we have also developed the G-spot Ballooning method for women to rejuvenate and regrow the smooth muscle, as described in http://action.love/WordPress/2015/08/14/g-spot-rejuvenation-and-natural-regrowth/

There are a lot of other benefits, as described in this article entitled: “How to perform Vagus Nerve Stimulation (VNS) from your bottom (pelvic floor) with VIP Cream , of course, without an electronic pulse generator?”  http://action.love/WordPress/2016/01/09/how-to-perform-vagus-nerve-stimulation-vns-from-your-bottom-pelvic-floor-with-vip-cream-of-course-without-an-electronic-pulse-generator/

By the way, if you can not take ViaPal-hGH-P, you can switch to ViaPal-hGH-M (3-014), ViaPal-hGH-E (3-011), or ViaPal-hGH-S (3-013) instead.  You want to boost dopamine, but can not take ViaPla-hGH-P, you can switch to ViaPal-hGH-A (3-020) or ViaPal-hGH-F (3-022).  You can find a suitable formula from http://linstitute.apollohosting.com/store/index.html

Or send it e-mail over from http://www.taonetworks.net/mailform.html

References:

1.  Dulak J¹, Józkowicz A, Dembinska-Kiec A, Guevara I, Zdzienicka A, Zmudzinska-Grochot D, Florek I, Wójtowicz A, Szuba A, and Cooke JP., ” Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells.” Arterioscler Thromb Vasc Biol. 2000 Mar;20(3):659-66. http://atvb.ahajournals.org/content/20/3/659.full.pdf+html
2.  Eu Chang Hwanga, Kyung Jin Oha, Seung Il Junga, Noel N. Kimb, Kyu Youn Ahnc, and Kwangsung Park,  “Effects of Androgen on the Expression of Vascular Endothelial Growth Factor in the Penile Corpus Cavernosum”
   Urology, Volume 77, Issue 6, June 2011, Pages 1381–1386
   http://www.sciencedirect.com/science/article/pii/S0090429511001099
3. Yamanaka M1, Shirai M, Shiina H, Tanaka Y, Enokida H, Tsujimura A, Matsumiya K, Okuyama A, and Dahiya R.,
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   http://www.ncbi.nlm.nih.gov/pubmed/15592104
4.  Shirai M1, Yamanaka M, Shiina H, Igawa M, Kawakami T, Ishii N, Lue TF, Fujime M, and Dahiya R., “Vascular endothelial growth factor restores erectile function through modulation of the insulin-like growth factor system and sex hormone receptors in diabetic rat.” Biochem Biophys Res Commun. 2006 Mar 17;341(3):755-62. Epub 2006 Jan 19.
   http://www.ncbi.nlm.nih.gov/pubmed/16455052
5. Lin CS1, Lue TF., “Growth factor therapy and neuronal nitric oxide synthase.” Int J Impot Res. 2004 Jun;16 Suppl 1:S38-9. http://www.ncbi.nlm.nih.gov/pubmed/15224135
6. Toda N1, Ayajiki K, and Okamura T, “Nitric oxide and penile erectile function. ” Pharmacol Ther. 2005 May;106(2):233-66. Epub 2005 Mar 2. http://www.ncbi.nlm.nih.gov/pubmed/15866322
7.  Kingston PA1, Sinha S, Appleby CE, David A, Verakis T, Castro MG, Lowenstein PR, and Heagerty AM, “Adenovirus-mediated gene transfer of transforming growth factor-beta3, but not transforming growth factor-beta1, inhibits constrictive remodeling and reduces luminal loss after coronary angioplasty.” Circulation. 2003 Dec 2;108(22):2819-25. Epub 2003 Nov 24. http://circ.ahajournals.org/content/108/22/2819.full.pdf+html
8.  Deasy BM1, Feduska JM, Payne TR, Li Y, Ambrosio F, and Huard J, “Effect of VEGF on the regenerative capacity of muscle stem cells in dystrophic skeletal muscle.”  Mol Ther. 2009 Oct;17(10):1788-98. doi: 10.1038/mt.2009.136. Epub 2009 Jul 14. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835014/pdf/mt2009136a.pdf
9.  Beckman SA1, Chen WC, Tang Y, Proto JD, Mlakar L, Wang B, Huard J., “Beneficial effect of mechanical stimulation on the regenerative potential of muscle-derived stem cells is lost by inhibiting vascular endothelial growth factor. “Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):2004-12. doi: 10.1161/ATVBAHA.11http://www.ncbi.nlm.nih.gov/pubmed/23723372#2.301166. Epub 2013 May 30.  http://atvb.ahajournals.org/content/33/8/2004.full.pdf+html
10.  Andrzejewski W, Kassolik K, Kobierzycki C1, Grzegrzolka J, Ratajczak-Wielgomas K, Jablonska K, Halski T, Dziegiel P, Gworys B, and Podhorska-Okolow M., “Increased skeletal muscle expression of VEGF induced by massage and exercise.”  Folia Histochem Cytobiol. 2015;53(2):145-51. doi: 10.5603/FHC.a2015.0013. Epub 2015 Jul 7.   https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/FHC.a2015.0013/29409
11.  Best TM1, Gharaibeh B, and  Huard J. “Stem cells, angiogenesis and muscle healing: a potential role in massage therapies? ”  Br J Sports Med. 2013 Jun;47(9):556-60. doi: 10.1136/bjsports-2012-091685. Epub 2012 Nov 29.  http://www.ncbi.nlm.nih.gov/pubmed/23197410
12. Cao H, Kang BJ, Lee CA, Shung KK, Hsiai TK., “Electrical and Mechanical Strategies to Enable Cardiac Repair and Regeneration.” IEEE Rev Biomed Eng. 2015;8:114-24. doi: 10.1109/RBME.2015.2431681. Epub 2015 May 11. http://www.ncbi.nlm.nih.gov/pubmed/25974948