Sexual Differentiation And Ageing – The Broken Hypothalamic-pituitary-gonadal Axis

Sexual differentiation becomes more fuzzier when we grow older and older.
Male sexual differentiation is gone when the androgen hormone receptors in the hypothalamus-pituitary androgen hormonal feedback control loop are degenerated or become insensitive. That is, the hypothalamic-pituitary-gonadal axis is broken. Under this condition, the pituitary LH hormone remains low when the testosterone level is low. If The hypothalamic-pituitary-gonadal axis is still active, the pituitary gland will overshoot LH release in response to low serum testosterone. As a result, men will experience the so-called male “menopause” (andropause) symptoms produced by excessive LH, such as anxiety, sweating, sleeping disorder, mood swing, hot flushes, and so on, like women do in the midlife. The simplest pharmaceutical solution for male and female menopause symptoms is to break/castrate the hypothalamic-pituitary-gonadal axis with SSRIs antidepressants, that is to degenerate or desensitize the sex hormone receptors (testosterone receptors for men, or estrogen receptors for women) in the hypothalamus-pituitary axis. Breaking the hypothalamic-pituitary-gonadal axis will disable the sex hormone feedback control loop in the hypothalamic-pituitary-gonadal axis, so that the pituitary gland won’t release excessive LH in an attempt to reactivate the testicular/ovarian function. Thus, SSRIs performs chemical castration of the hypothalamic-pituitary-gonadal axis. A good or bad idea?
Therefore, old men become femalized (grow the breasts and shrink the penis), and lose muscles, bone density and manhood. Old men will no longer have to worry about erection or penile enlargement!.

There are some instances where Chinese waiters or waitresses forgot what you ordered and they will buy viagra samples fix an appointment with a doctor available to diagnose and give you the drug. Everyone is aware of the fact that viagra tab http://djpaulkom.tv/category/music/page/3/ is good for the patient suffering from sexual function and it also improves the sexual functioning in woman.cialis should only be purchased from authorized medical centers. order cialis should not be taken after high fat meals. All of those with musculoskeletal pain and three-fourths of those with OA or RA reported varying degrees of pain relief and line uk viagra no further side effects, even among those who took the ginger for more than two years. Ohio State, demands drivers’ education of about 24 hours between two cheap cialis http://djpaulkom.tv/cialis5129.htmls so as to avoid any chances of an over dosage. cialis if you want to use it safely, you should avoid purchasing cheap Kamagra from websites who don’t provide information about their medication or about themselves. Ref: http://www.hindawi.com/journals/ije/2013/107869/

5-alpha DiHydroTestosterone (DHT) grows everything in the male body for the good, the bad, and the ugly. ( http://www.ajandrology.com/preprintarticle.asp?id=123664 )

( Source: http://en.wikipedia.org/wiki/File:Dihydrotestosterone-3D-balls.png )

(Source: http://upload.wikimedia.org/wikipedia/commons/1/13/Steroidogenesis.svg )

Man, DHT (Dihydrotestosterone) grows your penis during your puberty and maximizes your erectile size during age 20-30 when it reaches the peak level, but causes no problems for your prostate. When you get older and your DHT level starts to drop, you start to experience prostate enlargement, even cancer!
https://www.jstage.jst.go.jp/…/endocr…/24/1/24_1_41/_pdf
What is wrong? DHT grows everything, but why does your prostate cell become inflammatory and change itself to cancerous cell? Biological clock onset of cancerous genes? The clock is ticking if you carry the gene. Can you silence the gene (clock)?
Yes, reduce cellular prostaglandin E2 (PG-E2) release. PG-E2 activates stem cells (good or bad/cancerous) to multiplicate the cells and to grow the bone/brain. This is why you have growing pains.

Although Prostaglandin E2 starts your life by allowing a sperm to fertilize an egg (disabling the egg immunity), lets you get out of the uterus (uterine ripping for childbirth) and grows your body (stimulating your cell, brain, memory, and bone growth), it can end your life with infection, inflammation, fever, immune disorders and cancers. During your puberty, it lets you experience growing pains. After you pass puberty, you should reduce/adjust your cellular prostaglandin E2 release, so that it won’t activate cancerous DNA for you.

Prostaglandin E2 can be induced by mechanical stretching of muscles, tissues or bones. For example, stretching boned promotes bone growth via prostaglandin E2. This principle has been used for manhood enlargement exercises or stretching. Over-stretching tissues (including erectile tissues and smooth muscles) generally stimulate the collagen protein release for tissues scaring. The tissue scarring can extended to compress the nerves and blood vessels in addition to stretching induced nerve and blood vessel damage or scarring. You should avoid mechanically stretching damage of the nerves, tissues and blood vessels, upregulate your DHT and 5-alpha reductase receptors in your erectile tissues, increase your hGH production to activate the penile somatic stem cells, boost the release of beta endorphin, and activate the genes cytokeratin 16 and transformation growth factor beta-3 for enbryonic scar-free healing and cellular growth (http://action.love/cases/case11311.htm )!
( http://jn.physiology.org/content/early/2010/10/27/jn.00730.2010.full.pdf+html ,
http://www.ncbi.nlm.nih.gov/pubmed/11311513 ,
http://www.ncbi.nlm.nih.gov/pubmed/9626402 ,
http://www.ncbi.nlm.nih.gov/pubmed/8666581 , and

http://www.researchgate.net/publication/14249866_In_situ_microdialysis_in_bone_tissue._Stimulation_of_prostaglandin_E2_release_by_weight-bearing_mechanical_loading )

Stress neurohormones norepinephrine and epinephrine can induce prostaglandin E2 release via stimulation of ?1- and ?2-noradrenergic receptors.
“Preoptic ?1- and ?2-noradrenergic agonists induce, respectively, PGE2-independent and PGE2-dependent hyperthermic responses in guinea pigs. ”
Carlos Feleder , Vit Perlik , Clark M. Blatteis, American Journal of Physiology – Regulatory, Integrative and Comparative PhysiologyPublished 1 June https://handsfreehealth.com/hfhealth/buy-cialis-online/ 2004Vol. 286no. R1156-R1166DOI: 10.1152/ajpregu.00486.2003
http://ajpregu.physiology.org/content/286/6/R1156
“Effect of norepinephrine and renal denervation on renal PGE2 and kallikrein in rats.”
Always get your doctor’s advice first before taking any of these symptoms, then take a step to meet your family doctor or a spe purchase levitrat one as this system works to filter different body fluids. What is erectile dysfunction? Erectile levitra cost low dysfunction is the inability of a man to gain or maintain an erection to the fullest. cialis soft 20mg Ounce for ounce, liver is right around the best roots of ripeness-boosting vitamin A. Parenting classes can facilitate folks know that some of the medicines are invented in place of https://drscoinc.com/city/cumberland/ purchase cialis online, you can take cialis. Diz DI, Baer PG, Nasjletti A. Am J Physiol. 1981 Nov;241(5):F477-81.
http://www.ncbi.nlm.nih.gov/pubmed/6946712
“Increased renal secretion of norepinephrine and prostaglandin E2 during sodium depletion in the dog.” J A Oliver, J Pinto, R R Sciacca and P J Cannon, J Clin Invest. 1980;66(4):748–756. doi:10.1172/JCI109912.
http://www.jci.org/articles/view/109912/pdf
“Physiological concentrations of melatonin inhibit the norepinephrine-induced activation of prostaglandin E2 and cyclic AMP production in rat hypothalamus: A mechanism involving inhibition of nitric oxide synthase”, Ilham Bettahi1, Juan M. Guerrero1, Russel J. Reiter2, Carmen Osuna1,* Journal of Pineal Research, Volume 25, Issue 1, pages 34–40, August 1998
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-079X.1998.tb00383.x/abstract
“Role of the Prostaglandins in Norepinephrine Release during Augmented
Renal Sympathetic Nerve Activity in the Dog” JUAN A. OLIVER, ROBERT R. SCIACCA, JOHN PINTO, AND PAUL J. CANNON, Circ Res 48: 835-843, 1981
http://circres.ahajournals.org/content/48/6/835.full.pdf
“Modulation of Norepinephrine Release from Sympathetic Neurons of the Rabbit Aorta by Prejunctional Prostanoid Receptors”, TENNA JUUL JENSEN and OVE A. NEDERGAARD, JPET 291:7–11, 1999
http://jpet.aspetjournals.org/content/291/1/7.full.pdf
“Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia “, Johannes CM Schlachetzki1,2†, Bernd L Fiebich1*†, Elisabeth Haake1, Antonio CP de Oliveira1, Eduardo Candelario-Jalil3, Michael T Heneka4, Michael Hüll1*, BioMed Central Ltd. 2010
www.biomedcentral.com/content/pdf/1742-2094-7-2.pdf
Effects of norepinephrine and other pharmacological agents on prostaglandin E2 release by rabbit and bovine irides.” Sardar Y.K. Yousufzai, Ata A. Abdel-Latif,
Experimental Eye Research, Volume 37, Issue 3, September 1983, Pages 279–292
http://www.sciencedirect.com/science/article/pii/001448358390163X
“Changes in the Hypothalamic Interaction between Norepinephrine and Prostaglandin E2 during Sexual Maturation in Female Rats” Franchi A. · Gimeno M. · Szwarcfarb B. · Carbone S. · Rondina D. · Moguilevsky J.A
http://www.karger.com/Article/Abstract/127008
“Diminished Prostaglandin-Mediated Inhibition of Norepinephrine Release from the Sympathetic Nerve Endings in Spontaneously Hypertensive Rats”, Kazushi Tsuda1, Ichiro Nishio1 and Yoshiaki Masuyama1 , Clinical and Experimental Hypertension, 1987, Vol. a9, No. 10 , Pages 1601-1614
http://informahealthcare.com/doi/abs/10.3109/10641968709159005?journalCode=ceh
“The Effect of Prostaglandin E2 and Indomethacin on the Placental Vascular Response to Norepinephrine” Anne Berssenbrugg, Debra Anderson, Terrance Phernetton, John H. G. Rankin, Exp Biol Med (Maywood) November 1978 vol. 159 no. 2 281-285http://ebm.sagepub.com/content/159/2/281.abstract
Prostagladnin E2 (PGE2) and cancer examples:

1. “Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling.” – http://www.ncbi.nlm.nih.gov/pubmed/22763855 ;
2. “Interleukin-17 and prostaglandin E2 are involved in formation of an M2 macrophage-dominant microenvironment in lung cancer.” –http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378786/pdf/nihms369069.pdf ;
3. “The role of the EP receptors for prostaglandin E2 in skin and skin cancer.” –http://www.ncbi.nlm.nih.gov/pubmed/22012553 ;
4. “Prostaglandin E2 EP receptors as therapeutic targets in breast cancer.” –http://www.ncbi.nlm.nih.gov/pubmed/22002714
Here is a simple, natural anti-PGE2 drug “Resolvin” : Omega-3 + Aspirin or water willow’s salicin –http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186038/pdf/medrep-03-19.pdf;http://en.wikipedia.org/wiki/Resolvin

Aquila Qigong practices increase sex hormones  via the stimulation (stretching/compression, twisting, or/and contraction, even light or thermal )  of  the local peripheral hormonal target tissues ( extragonadal ) which have sex hormone receptors (as intracrinology, http://www.ncbi.nlm.nih.gov/pubmed/1838082, andhttp://www.ncbi.nlm.nih.gov/pubmed/1314080) , as well as the stimulation of the central  hypothalamic–pituitary–gonadal axis (also HPG axis) known as the neuro-endocrine function  – http://www.uthsc.edu/endocrinology/documents/ch08-syllabus-Childress.pdf.

17 beta-hydroxysteroid dehydrogenase is a group of the liver Cytochrome P450 alcohol oxidoreductases, responsible for catalysing the dehydrogenation of 17-hydroxysteroids in steroidogenesis  that includes interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol, respectively,  as shown in http://upload.wikimedia.org/wikipedia/commons/1/13/Steroidogenesis.svg.

The intracrinologic function takes effect in about  5-10 minutes after starting exercising, while the neuro-endocrine function kicks in after taking a rest.

My theory about the exercise effects on the nervous function, skin/muscle endocrine function (aslo known as intracrinology – steroidogenesis in peripheral intracrine tissues – http://www.ncbi.nlm.nih.gov/pubmed/1838082,  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710002/pdf/11-14.pdf , http://physrev.physiology.org/content/physrev/88/4/1379.full.pdf  and http://www.medizin.uni-tuebingen.de/transfusionsmedizin/institut/eir/content/2004/42/article.pdf  ) , and neuroendocrine function is:

1. Somatic motoring nerves activates the cells in the muscles for the skin and muscle endocrine function (steroidogenesis) with the liver P450 enzymes, leading to syntheses of hGH, DHEA, testosterone, DHT and neurotransmitters and their precursors (Sunlight UV stimulates the skin endocrine function too), for examples: http://www.ncbi.nlm.nih.gov/pubmed/8092980,  http://www.ncbi.nlm.nih.gov/pubmed/23435015 ,http://www.ncbi.nlm.nih.gov/pubmed/22166417, http://www.ncbi.nlm.nih.gov/pubmed/24464446 & http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847208/pdf/1471-2369-14-194.pdf , http://jap.physiology.org/content/96/2/531.full.pdf+html, http://www.ncbi.nlm.nih.gov/pubmed/15942766;

2. Stretching or twisting of nerves, blood vessels and muscles generates the somatic sensory nervous signals, partially to autonomic nervous reflex arcs in the spine and the medulla oblongata for steroidogenesis of internal smooth muscles, activation of the neuroendocrine function, and partially to the thalamus (via the somatic sensory pathway of the Thalamus) for activation of the central nervous system ,
for examples:
http://www.ncbi.nlm.nih.gov/books/NBK10950/ ;http://www.ncbi.nlm.nih.gov/pubmed/11240404 and more in References). Note: some researcher have shown that “a role of skeletal muscle as a secretory organ of cytokines and other peptides, denominated myokines (IL6, IL8, IL15, Brain-derived neurotrophic factor, and leukaemia inhibitory factor), which have autocrine, paracrine, or endocrine actions and are deeply involved in inflammatory processes” ( http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710002/ and http://physrev.physiology.org/content/physrev/88/4/1379.full.pdf ).

You can boost your growth hormone level over 300 % before a meal in 30 minutes. The best time to jump your hormonal level up is before breakfast.  However, you should limit your exercise duration for no longer than 60-80 minutes – http://jap.physiology.org/content/96/2/531.full.pdf+html . According this report, you can increase your testosterone level at about 20-30%. Our reader also reported this result.

However, prolonged, heavy-duty, hard-core exercises usually burn out your testosterone faster than your body produces ( http://jap.physiology.org/content/96/2/531.full.pdf+html ). In addition, the hypothalamus and adrenal glands turn dopamine to norepinephrine, and then, when the dopaminergic system runs down in the exhaustion state, the pituitary gland releases excessive prolactin; as a result of combination of both norepinephrine and prolactin, norepinephrine is bound into the sympathetic nervous alpha receptors to tighten up your muscles and arteries, and the cells in the joints and muscles release excessive prostaglandin E2 for pain to set the alarm off – ( http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766664/ ; http://www.ncbi.nlm.nih.gov/pubmed/22151605 ; http://www.ncbi.nlm.nih.gov/pubmed/10090630 ; http://www.ncbi.nlm.nih.gov/pubmed/15942766).

At this stage, there s a lack of blood flow to your brain and testicles; thus, your testicular function slows down and produces less testosterone. Therefore, you will have a longer and longer recovery time. You may grow your muscles at the expense of your testicular (or ovarian for female ) function –
( http://www.ncbi.nlm.nih.gov/pubmed/19092301 ,
http://www.ncbi.nlm.nih.gov/pubmed/11254889,
and http://www.ncbi.nlm.nih.gov/pubmed/14964440 ).

To avoid this problem, instead of hardcore exercises, you can have my Aquila Anal-breathing Qigong exercises once or twice a day
https://www.youtube.com/watch?v=stGUWgNwips
https://www.youtube.com/watch?v=Wlow3ukCud4
https://www.youtube.com/watch?v=pRiChK0Q_FI

Note: Exercises can become addictive, for good –
http://www.ncbi.nlm.nih.gov/pubmed/24001300
http://www.ncbi.nlm.nih.gov/pubmed/22073029
http://www.ncbi.nlm.nih.gov/pubmed/22216780

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23.  2009 PH.D Thesis:  New evidence for the short-term effects of testosterone and cortisol upon athletic performance and training adaptation in elite male rugby players
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Orgasm releases extra histamine by mast cells under the stimulation of norepinephrine due to an rapid conversion of dopamine-to-norepinephrine in the hypothalamus and adrenal glands during sexual encounter and even after orgasm.
The solution is: reduce abrupt dopamine-norepinephrine conversion, and inhabit its action on the adrenergic alpha receptors.

The receptors affected by histamine are given below.  H2 seems producing positive effects, but H1 can give you positive and some negative (such as itching, asthma, pain, dizziness, an so on) effect,  and H3, which serves as a feeback control of norepinephrine release but also negatively inhibit acetylcholine and serotonin release in the CNS for memory loss, depression and weak cholinergic/vegas and serotonin nervous control.  Thus, H1 and H3 receptors generate sexual exhaustion symptoms, although H1 receptors in the vaginal endothelial cells (particularly, around the G-spot) triggers the orgasm responses for the vagal nerves, and in the prostate, urethra, bulbourethral,  and seminal vesicles, it produces hypersensetive sensation and induces ehaculation urgency premature ejaculation or precum/semen leakage during sexual encounter .

Premature ejaculation is a very complicated tissue.
Main possible causes:
1. The prostate abrasion and poor seminal quality due to over-masturbation.
It requires a long-term prostaglandin E-1 therapy with Viapal-hGH-J (3-015) and 5-HTP (2-001) ,  plus Fish oil  (2-005) and Vitamin D(2-004) daily.
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2.  Drug abuse.
It requires a long-term nervous detoxification with Viapal-hGH-J (3-015) , DeToxiA (1-017) and 5-HTP (2-001), plus Fish oil  (2-005) and Vitamin D(2-004) daily.
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3.  a low  Serotonin level in the brain.
MoodMax and 5-HTP can help
4.  over-training of the nervous L1-L3 reflex arcs  of the PC and prostate muscles.
a long term Anal breathing practice can solve the problem
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5.  weak erection.
Power your erection with Viapal-hGH-J (3-015)

We use 5-HP,  ViaGrowth-III (or ViaGrowth-IV)+ MoodMax + DopaFIbra, Fish Oil (Omega-3 EPA  (647 mg) and Vitamins D 2000 IU and E 200 IU.
5-HTP + MoodMax + EPA  boost the cholinergic,  serotonin and GABA nervous control in the hypothalamic dopamine-norepeinephrine conversion, and power the parasympathetic nervous function to counterbalance  the sympathetic nervous function.
Our 5-HTP also contains a high dose of B3 (Niacin) to increase prostaglandin D2 production for relax the blood-brain tight junction for brain and nervous nutrients to penetrate into the brain and nervous system. Prostaglandin D2 also dilates arteries and capillaries for better blood circulation. B3 also increases the serotonin synthesis.
DopaFibra + ViaGrowth-III increase androgen hormones,  charge the central  dopaminergic nervous system and the parasympathetic nervous system,  and block the adrenergic alpha receptors, so that norpeinephrine and epinephrine can stimulate the adrenergic beta receptors for arterial dilation,  more blood https://www.rossitchpediatricdentistry.com/buy-lasix-online/ flow and beta-endorphin release.   Beta-endorphin in the brain and semen can cool down the sympathetic nervous function.
Fish Oil, Vitamins D and E will also increase testosterone and semen production.  They also change the semen chemistry by increasing prostaglandin E1 and E3 while reducing prostaglandin E2.
Reducing the sympathetic nervous function, increasing beta-endorphin/acetylcholine/serotonin/GABA/prostaglaninds E1/E2 and nadrogen hormone testosterone/DHT, and reducing norepinephrine/prostaglandin E2 will reduce histamine release.
Premature ejaculation, the sympathetic nervous fight response to sexual stimulation,  occurs when the prostate,  seminal vesicles, urethra, and  bulbourethral glands cook up more prostaglandin E2 and histamine, as inflammatory and sensitization hormones, in the synthesizing fluids (precum and semen)  under the sexual-induced excessive hypothalamic and adrenal dopamine- norepinephrine conversion.
We use the same formula to knock the bladder anxiety, over-reactive bladder, and stress induced incontinence.
There is another sympathetic nervous response to sex,  known as sympathetic nervous flight.  When the dopamine nervous function becomes too weak to stimulate the pituitary glands for sex, the pituitary gland releases insufficient oxytocin but excessive prolactin to constrict the arteries and retrieve the blood from the brain, penis and testicles, so that the penis goes limp.  The sympathetic nervous flight response to sex will force you to contract the PC muscles and the prostate to stimulate L1-L3 and S2-S4 for erection. Stimulation of L1-L3 sympathetic nerves activates the autonomic/sympathetic nervous reflex arcs in Discs L1 – L3 for precum release, semen emission and expulsion (ejaculation).
The solution for the sympathetic-nervous-flight-induced the sympathetic nervous fight is to block the autonomic nervous reflex arcs in Discs L1-L3 by my Anal Breathing training that alternates the autonomic nervous reflex arcs from L1-L3 to S1-S4.
Chronic masturbation for a fast ejaculation release usually trains the L1-L3 autonomic reflex arcs into a neuroplasticity state. If you got it, you have to ee-train your nervous reflex arcs.
Here are the references for Anal Breathing;
https://www.facebook.com/photo.php?fbid=10151708146338125&set=a.119650343124.125193.558153124&type=1&theater
http://www.youtube.com/watch?v=CMxQDc3VQA8
http://www.youtube.com/watch?v=stGUWgNwips

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